FLNA

Template:Short description Template:Cs1 config Template:Infobox gene Filamin A, alpha (FLNA) is a protein that in humans is encoded by the FLNA gene.

Structure

The structure of Filamin A, alpha includes an actin binding N terminal domain, 24 internal repeats and 2 hinge regions.

Function

Actin-binding protein, or filamin, is a 280-kD protein that crosslinks actin filaments into orthogonal networks in cortical cytoplasm and participates in the anchoring of membrane proteins for the actin cytoskeleton. Remodeling of the cytoskeleton is central to the modulation of cell shape and migration. Filamin A, encoded by the FLNA gene, is a widely expressed filamin that regulates the reorganization of the actin cytoskeleton by interacting with integrins, transmembrane receptor complexes, and secondary messengers. At least 31 disease-causing mutations in this gene have been discovered.

DNA repair

Interaction of FLNA with the BRCA1 protein is required for efficient regulation of early stages of DNA repair processes. FLNA is implicated in the control of the DNA repair process of homologous recombination and non-homologous end joining.

Interactions

Filamin has been shown to interact with:

• BRCA2,
• CD29
• CASR,
• FBLIM1,
• FILIP1,
• FLNB,
• NPHP1,
• RALA,
• SH2B3,
• TRIO, and
• VHL.

Further reading

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