Far upstream element-binding protein 1
Template:Short description Template:Infobox gene Far upstream element-binding protein 1 is a protein that in humans is encoded by the FUBP1 gene.[1][2]
This gene encodes a ssDNA binding protein that activates the far upstream element (FUSE) of c-myc and stimulates expression of c-myc in undifferentiated cells. Regulation of FUSE by FUBP occurs through single-strand binding of FUBP to the non-coding strand. This protein has been shown to function as an ATP-dependent DNA helicase.[2]
Interactions
Far upstream element-binding protein 1 has been shown to interact with MAPK14[3] and SMN1.[4]
Clinical Significance
FUBP1 gene deletion forms part of the 1p/19q codeletion mutation seen in oligodendroglioma, a form of primary brain tumour.[5] CIC gene is also lost in the 1p/19q codeletion mutation.
References
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Further reading
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