Pseudomonas exotoxin
(Redirected from Exotoxin A)
Template:Short description Template:Infobox nonhuman protein
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The Pseudomonas exotoxin (or exotoxin A) is an exotoxin produced by Pseudomonas aeruginosa.[1] Vibrio cholerae produces a similar protein called the Cholix toxin (Template:Uniprot).[2]
It inhibits elongation factor-2. It does so by ADP-ribosylation of EF2 using NAD+. This then causes the elongation of polypeptides to cease. This mechanism is similar to that of diphtheria toxin.[3]
It has been investigated as a treatment for hepatitis B[4] and cancer.[5]
References
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External links
- Template:Commonscatinline
- P11439 (eta) in InterPro domain view
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