EVC (gene)
Template:Short descriptionTemplate:Infobox geneScript error: No such module "Infobox".Template:Template otherScript error: No such module "Check for unknown parameters". EVC is a gene associated with Ellis–Van Creveld syndrome. It overlaps with the CRMP1 gene.[1]
EVC is one of two genes (the other being EVC2) that upon mutation give rise to EvC (Ellis-van Creveld) syndrome in humans and is found to act as a positive mediator for three hedgehog (Hh) signaling molecules.[2] Mice with an inactivation of the EVC gene (EVC −/−) were found to exhibit similar physical characteristics as humans, such as shortened limbs and dental impairments.[2] In a study of 65 individuals affected with EvC, mutations in the EVC gene were found in 20 of them, and primarily attributed to a frameshift resulting in a nonsense codon.[3] More mild physical characteristics not completely associated with EvC syndrome, such as those without the expected oral deformities can also be attributed to EVC gene mutations.[4]
See also
References
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