Eukaryotic translation initiation factor 4 gamma 1

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Template:Cs1 config Template:Short description Template:Infobox gene Eukaryotic translation initiation factor 4 gamma 1 is a protein that in humans is encoded by the EIF4G1 gene.[1][2]

Function

The protein encoded by this gene is a component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure, and recruitment of mRNA to the ribosome. Alternative splicing results in five transcript variants encoding four distinct isoforms.[3] eIF4G serves as a scaffold, interacting with mRNA and the other components of the eIF4F complex, as well as the PABP and eIF3.

Interactions

Eukaryotic translation initiation factor 4 gamma has been shown to interact with MKNK1,[4] EIF4A1,[5][6][7] EIF4E,[6][7][8][9][10] MKNK2[11] and PABPC1.[12]

See also

References

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Further reading

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