Ipratropium bromide/salbutamol
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Ipratropium bromide/salbutamol, sold under the brand name Combivent among others, is a combination medication used to treat chronic obstructive pulmonary disease (COPD).[1][2][3] It contains ipratropium (an anticholinergic) and salbutamol (albuterol, a β2-adrenergic agonist).[1]
Common side effects include sore throat, muscle cramps, and nausea.[1] Other side effects may include bronchospasm, allergic reactions, and upper respiratory tract infections.[1] Safety in pregnancy is unclear.[4][1]
The combination was approved for medical use in the United States in 1996.[5] It is available as a generic medication.[2] In 2022, it was the 178th most commonly prescribed medication in the United States, with more than 2Template:Nbspmillion prescriptions.[6][7]
Medical uses
Ipratropium bromide/salbutamol can be used for the treatment of COPD[3] and asthma.[8]
Society and culture
Since Combivent contains a chlorofluorocarbon-based propellant, its use was discontinued in 2013 in the United States and other countries. This is because chlorofluorocarbons are attributed to depletion of the ozone layer.[9]
References
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