N,N'-Diisopropylcarbodiimide
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| Abbreviations | DIC, DIPC |
| Template:Longitem | 878281 |
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| EC Number | Template:Unbulleted list |
| Template:Longitem | 101400 |
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| Template:Longitem | Template:Chembox Elements/molecular formula |
| Molar mass | Template:Chem molar mass |
| Appearance | Liquid |
| Density | 0.806 g/mL |
| Boiling point | Template:Chembox CalcTemperatures |
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N,Template:Prime-Diisopropylcarbodiimide is a carbodiimide used in peptide synthesis.[1][2] As a liquid, it is easier to handle than the commonly used [[Dicyclohexylcarbodiimide|N,Template:Prime-dicyclohexylcarbodiimide]], a waxy solid. In addition, N,Template:Prime-diisopropylurea, its byproduct in many chemical reactions, is soluble in most organic solvents, a property that facilitates work-up.
Safety
In vivo dermal sensitization studies according to OECD 429[3] confirmed DIC is a strong skin sensitizer, showing a response at 0.20 wt% in the Local Lymph Node Assay (LLNA) placing it in Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Dermal Sensitization Category 1A.[4] Thermal hazard analysis by differential scanning calorimetry (DSC) shows DIC poses minimal explosion risks.[5]