Cefradine
Template:Short description Template:Drugbox Cefradine (INN) or cephradine (BAN) is a first generation cephalosporin antibiotic.[1]
Indications
- Respiratory tract infections (such as tonsillitis, pharyngitis, and lobar pneumonia) caused by group A beta-hemolytic streptococci and S. pneumoniae (formerly D. pneumonia).[note 1]
- Otitis media caused by group A beta-hemolytic streptococci, S. pneumoniae, H. influenzae, and staphylococci.
- Skin and skin structure infections caused by staphylococci (penicillin-susceptible and penicillin-resistant) and beta-hemolytic streptococci.
- Urinary tract infections, including prostatitis, caused by E. coli, P. mirabilis and Klebsiella species.
Formulations
Cefradine is distributed in the form of capsules containing 250 mg or 500 mg, as a syrup containing 250 mg/5 ml, or in vials for injection containing 500 mg or 1 g.Script error: No such module "Unsubst".
It is not approved by the FDA for use in the United States.Script error: No such module "Unsubst".
Synthesis
Birch reduction of D-α-phenylglycine led to diene (2). This was N-protected using tert-butoxycarbonylazide and activated for amide formation via the mixed anhydride method using isobutylchloroformate to give 3. Mixed anhydride 3 reacted readily with 7-aminodesacetoxycephalosporanic acid to give, after deblocking, cephradine (5).
Production names
The antibiotic is produced under many brand names across the world.[5]
- Template:Flagicon Bangladesh: Ancef, Ancef forte, Aphrin, Avlosef, Cefadin, Cephadin, Cephran, Cephran-DS, Cusef, Cusef DS, Dicef , Dicef forte, Dolocef, Efrad, Elocef, Extracef, Extracef-DS, Intracef, Kefdrin, Lebac, Lebac Forte, Medicef, Mega-Cef, Megacin, Polycef, Procef, Procef, Procef forte, Rocef, Rocef Forte DS, Sefin, Sefin DS, Sefnin, Sefrad, Sefrad DS, Sefril, Sefril-DS, Sefro, Sefro-HS, Sephar, Sephar-DS, Septa, Sinaceph, SK-Cef, Sk-Cef DS, Supracef and Supracef-F, Torped, Ultrasef, Vecef, Vecef-DS, Velogen, Sinaceph, Velox
- Template:Flagicon China: Cefradine, Cephradine, Kebili, Saifuding, Shen You, Taididing, Velosef, Xianyi, and Xindadelei
- Template:Flagicon Colombia: Cefagram, Cefrakov, Cefranil , Cefrex, and Kliacef
- Template:Flagicon Egypt: Cefadrin, Cefadrine, Cephradine, Cephraforte, Farcosef, Fortecef, Mepadrin, Ultracef, and Velosef
- Template:Flagicon France: Dexef
- Template:Flagicon Hong Kong: Cefradine and ChinaQualisef-250
- Template:Flagicon Indonesia: Dynacef, Velodine, and Velodrom
- Template:Flagicon Lebanon: Eskacef, Julphacef, and Velosef
- Template:Flagicon Lithuania: Tafril
- Template:Flagicon Myanmar: Sinaceph
- Template:Flagicon Oman: Ceframed, Eskasef, Omadine, and Velocef
- Template:Flagicon Pakistan: Abidine, Ada-Cef, Ag-cef, Aksosef, Amspor, Anasef, Antimic, Atcosef, Bactocef, Biocef, Biodine, Velora, Velosef
- Template:Flagicon Peru: Abiocef, Cefradinal, Cefradur, Cefrid, Terbodina II, Velocef, Velomicin
- Template:Flagicon Philippines: Altozef, Racep, Senadex, Solphride, Yudinef, Zefadin, Zefradil, and Zolicef
- Template:Flagicon Poland: Tafril
- Template:Flagicon Portugal: Cefalmin, Cefradur
- Template:Flagicon South Africa: Cefril A
- Template:Flagicon South Korea: Cefradine and Tricef
- Template:Flagicon Taiwan: Cefadin, Cefamid, Cefin, Cekodin, Cephradine, Ceponin, Lacef, Licef-A, Lisacef, Lofadine, Recef, S-60, Sefree, Sephros, Topcef, Tydine, Unifradine, and U-Save
- Template:Flagicon UK: Cefradune (Kent)
- Template:Flagicon Vietnam: Eurosefro and Incef
See also
- Cephapirin
- Cephacetrile
- Cefamandole
- Ampicillin (Has the same chemical formula)
Notes
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- ↑ Penicillin is the usual drug of choice in the treatment and prevention of streptococcal infections, including the prophylaxis of rheumatic fever. Cefuroxime is generally effective in the eradication of streptococci from the nasopharynx
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References
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- ↑ Script error: No such module "citation/CS1".
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- ↑ U.S. patent 3485819
- ↑ <templatestyles src="Citation/styles.css"/>Template:Citation/make link, Weisenborn, Frank L.; Dolfini, Joseph E. & Bach, Georges G. et al., "α-Amino-cyclohexadienyl-alkylen-penicilline und -cephalosporine, ihre Salze, und Verfahren zu ihrer Herstellung [Alpha-amino-cyclohexadienyl-alkylene-penicillins and cephalosporins, their salts, and processes for their preparation]", published Script error: No such module "auto date formatter"., assigned to E. R. Squibb & Sons Inc.Script error: No such module "Check for unknown parameters".
- ↑ Script error: No such module "citation/CS1".
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