Bcl-2-like protein 1
Template:Short description Template:Cs1 configTemplate:Infobox gene Bcl-2-like protein 1 is a protein encoded in humans by the BCL2L1 gene. Through alternative splicing, the gene encodes both of the human proteins Bcl-xL and Bcl-xS.[1]
Function
The protein encoded by this gene belongs to the Bcl-2 protein family. Bcl-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (voltage-dependent anion channels (VDACs) opening. VDACs regulate mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform (Bcl-xL) acts as an apoptotic inhibitor and the shorter form (Bcl-xS) acts as an apoptotic activator.[1][2]
Interactions
BCL2-like 1 (gene) has been shown to interact with:
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- APAF1,[3][4]
- BAK1,[5][6][7][8][9]
- BCAP31,[10]
- BCL2L11,[7][11][12][13]
- BNIP3,[14]
- BNIPL,[15][16]
- BAD,[6][11][17][18][19][20][21][22][23][24][25]
- BAX,[6][18][26][27]
- BIK,[5][11][27][28]
- Bcl-2,[6][29]
- HRK,[7][30][31]
- IKZF3,[32]
- Noxa,[11][33]
- PPP1CA,[19]
- PSEN2[34]
- RAD9A,[5][17]
- RTN1,[35]
- RTN4,[35] and
- VDAC1.[36][37][38][39]
References
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Further reading
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