B3 domain
Template:Short description Template:Short description
Script error: No such module "Infobox".Template:Template other The B3 DNA binding domain (DBD) is a highly conserved domain found exclusively in transcription factors (≥40 species) (Pfam PF02362) combined with other domains (InterPro: IPR003340). It consists of 100-120 residues, includes seven beta strands and two alpha helices that form a DNA-binding pseudobarrel protein fold (SCOP 117343); it interacts with the major groove of DNA.[1]
B3 families
In Arabidopsis thaliana, there are three main families of transcription factors that contain B3 domain:[2]
- ARF (Auxin Response Factors)
- ABI3 (ABscisic acid Insensitive3)
- RAV (Related to ABI3/VP1)
| protein | ARF1-B3 | ABI3-B3 | RAV1-B3 |
|---|---|---|---|
| B3 structure derived by | molecular model[1] | molecular model[1] | NMR[1] |
| B3 recognition sequence | TGTCTC[3][4] | CATGCA[5][6] | CACCTG[7] |
Template:PDB[1] and Template:PDB[8] are only known NMR solution phase structures of the B3 DNA Binding Domain.
Related proteins
The N-terminal domain of restriction endonuclease EcoRII; the C-terminal domain of restriction endonuclease BfiI possess a similar DNA-binding pseudobarrel protein fold.[9][10]
See also
- Restriction endonuclease EcoRII
- Auxin
- Abscisic acid
References
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External links
- DBD database of predicted transcription factors Template:WebarchiveScript error: No such module "Citation/CS1". Uses a curated set of DNA-binding domains to predict transcription factors in all completely sequenced genomes
- Classification in the "Transcription factors" table according to the Transfac database.
- Database of Arabidopsis Transcription Factors
- B3 Template:Webarchive, RAV, and ARF Template:Webarchive family at PlantTFDB:Plant Transcription Factor Database