Alpha-1D adrenergic receptor

Template:Short description Template:Cs1 config Template:Infobox gene The alpha-1D adrenergic receptor (α_1D adrenoreceptor), also known as ADRA1D, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it.

Receptor

There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. They activate mitogenic responses and regulate growth and proliferation of many cells.

Gene

This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region.

Ligands

Many α₁ receptor ligands are non-selective for receptor subtypes.

Antagonists

• A-315456
• BMY 7378 (also α_2C antagonist)
• Domesticine
• Cyclazosin (slight α_1C selectivity)
• Tamsulosin (roughly equal affinity for α_1A)

See also

• Adrenergic receptor

External links

• Template:UCSC gene info
• Template:UCSC gene info