N-Acetylgalactosamine
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| Molar mass | 221.21 g/mol |
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| Template:Longitem | N-Acetylglucosamine Galactosamine Galactose |
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N-Acetylgalactosamine (GalNAc), is an amino sugar derivative of galactose.
Function
In humans it is the terminal carbohydrate forming the antigen of blood group A.[1]
It is typically the first monosaccharide that connects serine or threonine in particular forms of protein O-glycosylation.
N-Acetylgalactosamine is necessary for intercellular communication, and is concentrated in sensory nerve structures of both humans and animals.
GalNAc is also used as a targeting ligand in investigational antisense oligonucleotides and siRNA therapies targeted to the liver, where it binds to the asialoglycoprotein receptors on hepatocytes. [2]
See also
- Galactosamine
- Globoside
- (N-Acetylglucosamine) GlcNAc
References
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