6-methylsalicylic-acid synthase
Template:Short description Template:Infobox enzyme In enzymology, a 6-methylsalicylic-acid synthase (EC 2.3.1.165) is a polyketide synthase that catalyzes the chemical reaction
- acetyl-CoA + 3 malonyl-CoA + NADPH + H+ 6-methylsalicylate + 4 CoA + 3 CO2 + NADP+ + H2O
6-methylsalicylic-acid synthase reaction
The 4 substrates of this enzyme are acetyl-CoA, malonyl-CoA, NADPH, and H+, whereas its 5 products are 6-methylsalicylate, CoA, CO2, NADP+, and H2O.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl-reducing, thioester-hydrolysing and cyclizing). Other names in common use include MSAS, and 6-methylsalicylic acid synthase.
References
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