1,2-Dimethoxybenzene
1,2-Dimethoxybenzene, commonly known as veratrole, is an organic compound with the formula C6H4(OCH3)2. It is one of three isomers of dimethoxybenzene. It is a colorless liquid, with a pleasant odor and slight solubility in water. It is the dimethyl ether derived from pyrocatechol.
Occurrence
1,2-Dimethoxybenzene is naturally occurring. Its biosynthesis entails the methylation of guaiacol by guaiacol O-methyltransferase.[1] 1,2-Dimethoxybenzene is an insect attractant.[1] Guaiacol O-methyltransferase gene is first scent gene discovered so far in any plant species.[1]
Uses
1,2-Dimethoxybenzene is a building block for the organic synthesis of other aromatic compounds. Veratrole is relatively electron-rich and thus readily undergoes electrophilic substitution.[2]
An example of the use of veratrole is in the synthesis of Domipizone.[3]
Veratrole can easily be brominated with NBS to give 4-bromoveratrole.[4]
Related compounds
References
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