α,N-DMT
α,N-Dimethyltryptamine (α,N-DMT; developmental code names SK&F-7024, Ro 3-1715), also known as N-methyl-α-methyltryptamine (N-methyl-αMT), is a lesser-known substituted tryptamine and psychoactive drug.[1] It is the α,N-dimethyl positional isomer of N,N-dimethyltryptamine (N,N-DMT).[1]
α,N-DMT was synthesized and assessed by Alexander Shulgin.[1] In his book TiHKAL (Tryptamines I Have Known and Loved), Shulgin lists the route as oral, the dosage as 50 to 100Script error: No such module "String".mg, and the duration as 6 to 8Script error: No such module "String".hours.[1] It seemed to produce some stimulant-like effects but no apparent euphoric, entactogenic, or psychedelic effects.[1] α,N-DMT also caused an unpleasant body load.[1]
Very little data exists about the pharmacological properties, metabolism, and toxicity of α,N-DMT.[1] α,N-DMT is known to be a potent monoamine oxidase inhibitor and tryptamine or serotonin receptor antagonist.[2][1] Close analogues of α,N-DMT, such as α-methyltryptamine (αMT), are known to act as monoamine releasing agents and serotonin receptor agonists.[3]
α,N-DMT is the N-methylated analogue of αMT.[1] There are notable parallels between the substituted tryptamines and substituted phenethylamines here in that α,N-DMT is to αMT as methamphetamine (N-methyl-α-methylphenethylamine) is to amphetamine (α-methylphenethylamine).[1]
See also
- α,N,N-Trimethyltryptamine (α,N,N-TMT)
- α,N,N,O-Tetramethylserotonin (α,N,N,O-TeMS)
- BK-NM-AMT
- Indolylpropylaminopentane (α,N-DPT)
References
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External links
- α-Methyl-NMT - Isomer Design
- α,N-DMT - TiHKAL - Erowid
- α,N-DMT - TiHKAL - Isomer Design
- What is Alpha,N-DMT? (α,N-DMT) - Tripsitter
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