Interolog

An interolog is a conserved interaction between a pair of proteins which have interacting homologs in another organism. The term was introduced in a 2000 paper by Walhout et al.

Example

A

Suppose that A and B are two different interacting human proteins, and A' and B' are two different interacting dog proteins. Then the interaction between A and B is an interolog of the interaction between A' and B' if the following conditions all hold:

• A is a homolog of A'. (Protein homologs have similar amino acid sequences and derive from a common ancestral sequence).
• B is a homolog of B'.
• A and B interact.
• A' and B' interact.

Thus, interologs are homologous pairs of protein interactions across different organisms.

See also

• Homology (biology)
• Systems biology
• Bioinformatics

External links

• Interactome.org Template:Webarchive: Interactome portal site.
• Template:Usurped: Interactomics portal site.
• [1]: Cross-species interaction prediction site.

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