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{{Infobox gene}}
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'''Intrinsic factor''' ('''IF'''), also known as  '''cobalamin binding intrinsic factor''',<ref name="uniprot" /> or '''gastric intrinsic factor''' ('''GIF'''), is a [[glycoprotein]] produced by the [[parietal cell]]s (in humans) or chief cells (in rodents) of the [[stomach]]. It is necessary for the absorption of [[vitamin B12|vitamin B<sub>12</sub>]] later on in the distal [[ileum]] of the [[small intestine]].<ref name="Pocock_2006">{{cite book | vauthors = Pocock G, Richards C | title = Human Physiology: The Basis of Medicine | isbn = 978-019-856878-0 | pages = 230 | date = 2006 | publisher = Oxford University Press | edition = 3rd }}</ref> In humans, the gastric intrinsic factor [[protein]] is encoded by the ''CBLIF'' [[gene]].<ref name="uniprot">{{cite web | title = CBLIF - Cobalamin binding intrinsic factor precursor - Homo sapiens (Human) - CBLIF gene & protein | url = https://www.uniprot.org/uniprot/P27352 | website = www.uniprot.org | access-date = 15 March 2022 | language = en }}</ref> [[Haptocorrin]] ([[Transcobalamin|transcobalamin I]]) is another glycoprotein secreted by the [[salivary gland]]s which binds to  vitamin B<sub>12</sub>. Vitamin B<sub>12</sub> is acid-sensitive and in binding to haptocorrin it can safely pass through the acidic stomach to the duodenum.<ref name="Fedosov_2012" />
'''Intrinsic factor''' ('''IF'''), also known as  '''cobalamin binding intrinsic factor''',<ref name="uniprot" /> or '''gastric intrinsic factor''' ('''GIF'''), is a [[glycoprotein]] produced by the [[parietal cell]]s (in humans) or [[Gastric chief cell|chief cells]] (in rodents) of the [[stomach]]. It is necessary for the absorption of [[vitamin B12|vitamin B<sub>12</sub>]] later on in the distal [[ileum]] of the [[small intestine]].<ref name="Pocock_2006">{{cite book | vauthors = Pocock G, Richards C | title = Human Physiology: The Basis of Medicine | isbn = 978-019-856878-0 | pages = 230 | date = 2006 | publisher = Oxford University Press | edition = 3rd }}</ref> In humans, the gastric intrinsic factor [[protein]] is encoded by the ''CBLIF'' [[gene]].<ref name="uniprot">{{cite web | title = CBLIF - Cobalamin binding intrinsic factor precursor - Homo sapiens (Human) - CBLIF gene & protein | url = https://www.uniprot.org/uniprot/P27352 | website = www.uniprot.org | access-date = 15 March 2022 | language = en }}</ref> [[Haptocorrin]] ([[Transcobalamin|transcobalamin I]]) is another glycoprotein secreted by the [[salivary gland]]s which binds to  vitamin B<sub>12</sub>. Vitamin B<sub>12</sub> is acid-sensitive and in binding to haptocorrin it can safely pass through the acidic stomach to the duodenum.<ref name="Fedosov_2012" />


In the less acidic environment of the [[small intestine]], pancreatic enzymes digest the glycoprotein carrier and vitamin B<sub>12</sub> can then bind to intrinsic factor.<ref name="Fedosov_2012" /> This new complex is then absorbed by the epithelial cells ([[enterocyte]]s) of the [[ileum]].<ref name="Fedosov_2012">{{cite book | vauthors = Fedosov SN | chapter = Physiological and Molecular Aspects of Cobalamin Transport | title = Water Soluble Vitamins | volume = 56 | pages = 347–367 | year = 2012 | pmid = 22116708 | doi = 10.1007/978-94-007-2199-9_18 | department = (review) | series = Subcellular Biochemistry | isbn = 978-94-007-2198-2 }}</ref> Inside the cells, vitamin B<sub>12</sub> dissociates once again and binds to another protein, [[transcobalamin|transcobalamin II]]; the new complex can then exit the epithelial cells to be carried to the liver.<ref name="Alpers_2013">{{cite journal | vauthors = Alpers DH, Russell-Jones G | title = Gastric intrinsic factor: the gastric and small intestinal stages of cobalamin absorption. A personal journey | journal = Biochimie | volume = 95 | issue = 5 | pages = 989–994 | date = May 2013 | pmid = 23274574 | doi = 10.1016/j.biochi.2012.12.006 | department = (review) }}</ref>
In the less acidic environment of the [[small intestine]], pancreatic enzymes digest the glycoprotein carrier and vitamin B<sub>12</sub> can then bind to intrinsic factor.<ref name="Fedosov_2012" /> This new complex is then absorbed by the epithelial cells ([[enterocyte]]s) of the [[ileum]].<ref name="Fedosov_2012">{{cite book | vauthors = Fedosov SN | chapter = Physiological and Molecular Aspects of Cobalamin Transport | title = Water Soluble Vitamins | volume = 56 | pages = 347–367 | year = 2012 | pmid = 22116708 | doi = 10.1007/978-94-007-2199-9_18 | department = (review) | series = Subcellular Biochemistry | isbn = 978-94-007-2198-2 }}</ref> Inside the cells, vitamin B<sub>12</sub> dissociates once again and binds to another protein, [[transcobalamin|transcobalamin II]]; the new complex can then exit the epithelial cells to be carried to the liver.<ref name="Alpers_2013">{{cite journal | vauthors = Alpers DH, Russell-Jones G | title = Gastric intrinsic factor: the gastric and small intestinal stages of cobalamin absorption. A personal journey | journal = Biochimie | volume = 95 | issue = 5 | pages = 989–994 | date = May 2013 | pmid = 23274574 | doi = 10.1016/j.biochi.2012.12.006 | department = (review) }}</ref>

Latest revision as of 17:56, 6 June 2025

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Intrinsic factor (IF), also known as cobalamin binding intrinsic factor,[1] or gastric intrinsic factor (GIF), is a glycoprotein produced by the parietal cells (in humans) or chief cells (in rodents) of the stomach. It is necessary for the absorption of vitamin B12 later on in the distal ileum of the small intestine.[2] In humans, the gastric intrinsic factor protein is encoded by the CBLIF gene.[1] Haptocorrin (transcobalamin I) is another glycoprotein secreted by the salivary glands which binds to vitamin B12. Vitamin B12 is acid-sensitive and in binding to haptocorrin it can safely pass through the acidic stomach to the duodenum.[3]

In the less acidic environment of the small intestine, pancreatic enzymes digest the glycoprotein carrier and vitamin B12 can then bind to intrinsic factor.[3] This new complex is then absorbed by the epithelial cells (enterocytes) of the ileum.[3] Inside the cells, vitamin B12 dissociates once again and binds to another protein, transcobalamin II; the new complex can then exit the epithelial cells to be carried to the liver.[4]

Site of secretion

Intrinsic factor is secreted by parietal cells within the stomach, and so is present in the gastric juice as well as in the gastric mucous membrane.[5] The optimum pH for its action is approximately 7.[6] Its concentration does not correlate with the amount of HCl or pepsin in the gastric juice, e.g., intrinsic factor may be present even when pepsin is largely absent.[7] The site of formation of the intrinsic factor varies in different species. In pigs it is obtained from the pylorus and beginning of the duodenum;[8] in human beings it is present in the fundus and body of the stomach.[9]

The limited amount of normal human gastric intrinsic factor limits normal efficient absorption of B12 to about 2 μg per meal, a nominally adequate intake of B12.[10]

Insufficiency

In pernicious anemia, which is usually an autoimmune disease, autoantibodies directed against intrinsic factor or parietal cells themselves lead to an intrinsic factor deficiency, malabsorption of vitamin B12, and subsequent megaloblastic anemia.[11] Atrophic gastritis can also cause intrinsic factor deficiency and anemia through damage to the parietal cells of the stomach wall.[12] Pancreatic exocrine insufficiency can interfere with normal dissociation of vitamin B12 from its binding proteins in the small intestine, preventing its absorption via the intrinsic factor complex.[13] Other risk factors contributing to pernicious anemia are anything that damages or removes a portion of the stomach's parietal cells, including bariatric surgery, gastric tumors, gastric ulcers, and excessive consumption of alcohol.Script error: No such module "Unsubst".

Mutations in the GIF gene are responsible for a rare inheritable disease called intrinsic factor deficiency[14] which results in malabsorption of vitamin B12.[15]

Treatment

In most countries, intramuscular injections of vitamin B12 are used to treat pernicious anemia.[16] Orally administered vitamin B12 is absorbed without intrinsic factor, but at levels of less than one percent than if intrinsic factor is present.[17] Despite the low amounts absorbed, oral vitamin B12 therapy is effective at reducing symptoms of pernicious anemia.[18]

Vitamin B12 can also be given sublingually, but there is no evidence that this route of administration is superior to the oral route,[19] and only Canada and Sweden routinely prescribe this route of administration.[16]

Because vitamin B12 absorption is a multistep process that involves the stomach, pancreas and small intestine, and is mediated by two carriers: Haptocorrin and intrinsic factor, and because Haptocorrin (transcobalamin I) binds to vitamin B12, and Vitamin B12 is acid-sensitive, when vitamin B12 binds to Haptocorrin it can safely pass through the acidic stomach to the duodenum, given time in the mouth.[3]

References

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Further reading

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External links

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