Reflux suppressant: Difference between revisions
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Added statistic and citation to back up claim on the efficacy of alginic rafts |
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A '''reflux suppressant''' is any one of a number of [[Medication|drugs]] used to combat [[oesophageal reflux]].<ref>{{cite journal | A '''reflux suppressant''' is any one of a number of [[Medication|drugs]] used to combat [[oesophageal reflux]].<ref>{{cite journal |doi=10.1111/j.1742-1241.2007.01524.x |last1=Dettmar |first1=P.W. |last2=Hampson |first2=F.C. |last3=Taubel |first3=J. |last4=Lorch |first4=U. |last5=Johnstone |first5=L.M. |last6=Sykes |first6=J. |last7=Berry |first7=P.J. |year=2007 |title=The suppression of gastro-oesophageal reflux by alginates |journal=International Journal of Clinical Practice |volume=61 |issue=10 |pages=1654–1662|pmid=17681004 |s2cid=11035501 |doi-access=free }}</ref><ref>{{cite book |url=https://www.researchgate.net/publication/235428948 |last1=Strugala |first1=V. |last2=Dettmar |first2=P.W. |year=2010 |chapter=Alginate in the treatment of extra-oesophageal reflux |title=Effects, Diagnosis and Management of Extra-Esophageal Reflux |pages=145–168}}</ref> Commonly, following ingestion a 'raft' of [[alginic acid]] is created, floating on the stomach contents by carbon dioxide released by the drug. This forms a mechanical barrier to further reflux. Some preparations also contain [[antacid]]s to protect the [[oesophagus]].<ref>{{cite journal |url=https://journals.sagepub.com/doi/pdf/10.1177/147323000503300305 |doi=10.1177/147323000503300305 |last1=Dettmar |first1=P.W. |last2=Little |first2=S.L. |last3=Baxter |first3=T. |year=2005 |title=The effect of omeprazole pre-treatment on rafts formed by reflux suppressant tablets containing alginate |journal=Journal of International Medical Research |volume=33 |issue=3 |pages=301–308|pmid=15938591 |s2cid=39712911 |url-access=subscription }}</ref> Alginate-based reflux suppressants relieve heartburn or regurgitation symptoms in about 60–70% of patients.<ref>{{cite web |last1=Jain |first1=Rishab |title=Reflux Suppressants: Mechanisms, Efficacy, and Clinical Use |url=https://claisen.com/reflux-suppressants-mechanisms-efficacy-and-clinical-use/ |website=Claisen |publisher=Claisen, Inc |access-date=6 November 2025}}</ref> | ||
Reflux can also be coincidentally reduced by the [[:Category:Motility stimulants|motility stimulants]] and [[antidopaminergic]]s.{{citation needed|date=November 2021}} | Reflux can also be coincidentally reduced by the [[:Category:Motility stimulants|motility stimulants]] and [[antidopaminergic]]s.{{citation needed|date=November 2021}} | ||
Latest revision as of 13:02, 6 November 2025
A reflux suppressant is any one of a number of drugs used to combat oesophageal reflux.[1][2] Commonly, following ingestion a 'raft' of alginic acid is created, floating on the stomach contents by carbon dioxide released by the drug. This forms a mechanical barrier to further reflux. Some preparations also contain antacids to protect the oesophagus.[3] Alginate-based reflux suppressants relieve heartburn or regurgitation symptoms in about 60–70% of patients.[4]
Reflux can also be coincidentally reduced by the motility stimulants and antidopaminergics.Script error: No such module "Unsubst".