Hypericin: Difference between revisions
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'''Hypericin''' is a carbopolycyclic compound derived from bisanthene with [[antidepressant]] properties, found in various ''[[Hypericum]]'' species, and is being studied for treating [[Skin|cutaneous]] [[T-cell | '''Hypericin''' is a carbopolycyclic compound derived from bisanthene with [[antidepressant]] properties, found in various ''[[Hypericum]]'' species, and is being studied for treating [[Skin|cutaneous]] [[T-cell lymphoma]].<ref>{{Cite web |last=PubChem |title=Hypericin |url=https://pubchem.ncbi.nlm.nih.gov/compound/Hypericin |access-date=2025-05-22 |website=pubchem.ncbi.nlm.nih.gov |language=en}}</ref> | ||
Opinions differ on the extent to which hypericin exhibits antidepressant effects. According to some scholars, hypericin, along with other active compounds in ''Hypericum perforatum'' (St. John’s wort), contributes to the antidepressant effects of the total plant [[extract]].<ref>Butterweck, V., & Schmidt, M. (2007). St. John’s wort: Role of active compounds for its mechanism of action and efficacy. Wiener Medizinische Wochenschrift, 157(13-14), 356–361. https://doi.org/10.1007/s10354-007-0440-8</ref> According to others, hypericin does not significantly [[Monoamine oxidase inhibitor|inhibit monoamine oxidase]] and thus is unlikely to account for the antidepressant effects of ''Hypericum'' extract.<ref>{{Cite journal|last1=Bladt|first1=S.|last2=Wagner|first2=H.|date=October 1994|title=Inhibition of MAO by fractions and constituents of hypericum extract|journal=Journal of Geriatric Psychiatry and Neurology|volume=7|issue=Suppl 1 |pages=S57–59|doi=10.1177/089198879400700115|issn=0891-9887|pmid=7857511|s2cid=23531061}}</ref> While another hypericin shows affinity mainly for [[NMDA receptor|NMDA receptors]], suggesting that other plant constituents likely play a more significant role in its antidepressant effects.<ref>{{Cite journal |last=Cott |first=J. M. |date=1997 |title=In vitro receptor binding and enzyme inhibition by Hypericum perforatum extract |url=https://pubmed.ncbi.nlm.nih.gov/9342770 |journal=Pharmacopsychiatry |volume=30 Suppl 2 |pages=108–112 |doi=10.1055/s-2007-979529 |issn=0176-3679 |pmid=9342770}}</ref> | Opinions differ on the extent to which hypericin exhibits antidepressant effects. According to some scholars, hypericin, along with other active compounds in ''Hypericum perforatum'' (St. John’s wort), contributes to the antidepressant effects of the total plant [[extract]].<ref>Butterweck, V., & Schmidt, M. (2007). St. John’s wort: Role of active compounds for its mechanism of action and efficacy. Wiener Medizinische Wochenschrift, 157(13-14), 356–361. https://doi.org/10.1007/s10354-007-0440-8</ref> According to others, hypericin does not significantly [[Monoamine oxidase inhibitor|inhibit monoamine oxidase]] and thus is unlikely to account for the antidepressant effects of ''Hypericum'' extract.<ref>{{Cite journal|last1=Bladt|first1=S.|last2=Wagner|first2=H.|date=October 1994|title=Inhibition of MAO by fractions and constituents of hypericum extract|journal=Journal of Geriatric Psychiatry and Neurology|volume=7|issue=Suppl 1 |pages=S57–59|doi=10.1177/089198879400700115|issn=0891-9887|pmid=7857511|s2cid=23531061}}</ref> While another hypericin shows affinity mainly for [[NMDA receptor|NMDA receptors]], suggesting that other plant constituents likely play a more significant role in its antidepressant effects.<ref>{{Cite journal |last=Cott |first=J. M. |date=1997 |title=In vitro receptor binding and enzyme inhibition by Hypericum perforatum extract |url=https://pubmed.ncbi.nlm.nih.gov/9342770 |journal=Pharmacopsychiatry |volume=30 Suppl 2 |pages=108–112 |doi=10.1055/s-2007-979529 |issn=0176-3679 |pmid=9342770}}</ref> | ||
Latest revision as of 11:24, 17 June 2025
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Hypericin is a carbopolycyclic compound derived from bisanthene with antidepressant properties, found in various Hypericum species, and is being studied for treating cutaneous T-cell lymphoma.[1]
Opinions differ on the extent to which hypericin exhibits antidepressant effects. According to some scholars, hypericin, along with other active compounds in Hypericum perforatum (St. John’s wort), contributes to the antidepressant effects of the total plant extract.[2] According to others, hypericin does not significantly inhibit monoamine oxidase and thus is unlikely to account for the antidepressant effects of Hypericum extract.[3] While another hypericin shows affinity mainly for NMDA receptors, suggesting that other plant constituents likely play a more significant role in its antidepressant effects.[4]
Hypericin is a structurally complex phenanthroperylene quinone with potential medical and photoreceptive applications.[5] It is red-colored, photosensitive compound whose biosynthesis is catalyzed by the gene Hyp-1, a Bet v 1-class allergen identified through red-color-based colony screening and shown to convert emodin to hypericin with high efficiency.[6] It is thought to be synthesized by the PR-10 protein Hyp-1 through emodin dimerization, but despite confirming Hyp-1’s structure and ligand-binding capability, its catalytic role in hypericin biosynthesis remains unproven.[7]
Biotechnological research is exploring in vitro culture methods to enhance and stabilize the production of hypericin.[8]
References
Template:Glutamate receptor modulators Template:Sigma receptor modulators
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- ↑ Butterweck, V., & Schmidt, M. (2007). St. John’s wort: Role of active compounds for its mechanism of action and efficacy. Wiener Medizinische Wochenschrift, 157(13-14), 356–361. https://doi.org/10.1007/s10354-007-0440-8
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