Rizatriptan: Difference between revisions
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* [[Propranolol]]<ref name="Millson 2000">{{cite journal | vauthors = Millson DS, Tepper SJ, Rapoport AM | title = Migraine pharmacotherapy with oral triptans: a rational approach to clinical management | journal = Expert Opinion on Pharmacotherapy | volume = 1 | issue = 3 | pages = 391–404 | date = March 2000 | pmid = 11249525 | doi = 10.1517/14656566.1.3.391 | s2cid = 36053513 }}</ref>{{Explain|date=October 2024}} | * [[Propranolol]]<ref name="Millson 2000">{{cite journal | vauthors = Millson DS, Tepper SJ, Rapoport AM | title = Migraine pharmacotherapy with oral triptans: a rational approach to clinical management | journal = Expert Opinion on Pharmacotherapy | volume = 1 | issue = 3 | pages = 391–404 | date = March 2000 | pmid = 11249525 | doi = 10.1517/14656566.1.3.391 | s2cid = 36053513 }}</ref>{{Explain|date=October 2024}} | ||
==Mechanism of action== | ==Pharmacology== | ||
{{ | ===Mechanism of action=== | ||
{{Further|Serotonin receptor agonist|Triptan#Mechanism of action}} | |||
Rizatriptan acts as an agonist at serotonin [[5-HT1B|5-HT<sub>1B</sub>]] and [[5-HT1D|5-HT<sub>1D</sub>]] receptors.<ref name="Wellington 2002">{{cite journal | vauthors = Wellington K, Plosker GL | title = Rizatriptan: an update of its use in the management of migraine | journal = Drugs | volume = 62 | issue = 10 | pages = 1539–74 | year = 2002 | pmid = 12093318 | doi = 10.2165/00003495-200262100-00007 | s2cid = 195693597 }}</ref> Like the other [[triptans]] [[sumatriptan]] and [[zolmitriptan]], rizatriptan induces [[vasoconstriction]]—possibly by inhibiting the release of [[calcitonin gene-related peptide]] from sensory neurons in the [[trigeminal nerve]].<ref name="Wellington 2002"/> | Rizatriptan acts as an agonist at serotonin [[5-HT1B|5-HT<sub>1B</sub>]] and [[5-HT1D|5-HT<sub>1D</sub>]] receptors.<ref name="Wellington 2002">{{cite journal | vauthors = Wellington K, Plosker GL | title = Rizatriptan: an update of its use in the management of migraine | journal = Drugs | volume = 62 | issue = 10 | pages = 1539–74 | year = 2002 | pmid = 12093318 | doi = 10.2165/00003495-200262100-00007 | s2cid = 195693597 }}</ref> Like the other [[triptans]] [[sumatriptan]] and [[zolmitriptan]], rizatriptan induces [[vasoconstriction]]—possibly by inhibiting the release of [[calcitonin gene-related peptide]] from sensory neurons in the [[trigeminal nerve]].<ref name="Wellington 2002"/> | ||
==Chemistry== | |||
The experimental [[log P]] is 1.4 and its predicted log P is 1.67 to 1.77.<ref name="PubChem">{{cite web | title=Rizatriptan | website=PubChem | url=https://pubchem.ncbi.nlm.nih.gov/compound/5078 | access-date=27 June 2025}}</ref><ref name="DrugBank">{{cite web | title=Rizatriptan: Uses, Interactions, Mechanism of Action | website=DrugBank Online | date=14 June 2012 | url=https://go.drugbank.com/drugs/DB00953 | access-date=27 June 2025}}</ref> | |||
== Society and culture == | == Society and culture == | ||
Latest revision as of 22:33, 27 June 2025
Template:Short description Template:Use dmy dates Template:Cs1 config Template:Drugbox
Rizatriptan, sold under the brand name Maxalt among others, is a medication used for the treatment of migraine headaches.[1][2] It is taken by mouth.[1][2] It can also be applied on the tongue.[3] It is a serotonin (5-HT) 1B/1D receptor agonist (triptan).[1][3]
Common side effects include chest pain, dizziness, dry mouth, and tingling.[2] Other side effects may include myocardial infarction, stroke, high blood pressure, serotonin syndrome, and anaphylaxis.[2] Excessive use may result in medication overuse headaches.[2] Use is not recommended during pregnancy and breastfeeding is not recommended within 24 hours after taking a dose.[4] Rizatriptan is in the triptan class and is believed to work by activating the 5-HT1 receptor.[2]
Rizatriptan was patented in 1991 and came into medical use in 1998.[5][6] It is available as a generic medication.[4] In 2022, it was the 190th most commonly prescribed medication in the United States, with more than two million prescriptions.[7][8] Rizatriptan is available in combination with meloxicam as meloxicam/rizatriptan.
Medical uses
Rizatriptan is indicated to treat acute migraine attacks with or without aura.[1][3] It does not prevent future migraine attacks.[9] A 2010 review found rizatriptan to be more efficacious and tolerable than sumatriptan.[10]
Contraindications
Rizatriptan and other triptans can cause vasoconstriction, they are contraindicated in people with cardiovascular conditions.[11]
Adverse effects
Frequent adverse effects (incidence less than 10%) are dizziness, drowsiness, asthenia/fatigue, and nausea. Clinical adverse experiences were typically mild and short-lasting (2–3 hours).[11]
Interactions
Pharmacology
Mechanism of action
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Rizatriptan acts as an agonist at serotonin 5-HT1B and 5-HT1D receptors.[13] Like the other triptans sumatriptan and zolmitriptan, rizatriptan induces vasoconstriction—possibly by inhibiting the release of calcitonin gene-related peptide from sensory neurons in the trigeminal nerve.[13]
Chemistry
The experimental log P is 1.4 and its predicted log P is 1.67 to 1.77.[14][15]
Society and culture
Brand names
Brand names include Rizalt, Rizalt RPD, Rizact (India), Rizafilm,[3] Maxalt,[1] and Maxalt-MLT.[1][16][17][18]
References
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