Intercellular adhesion molecule: Difference between revisions
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In [[molecular biology]], '''intercellular adhesion molecules''' ('''ICAMs''') and [[vascular cell adhesion molecule-1]] (VCAM-1) are part of the [[immunoglobulin superfamily]]. They are important in [[inflammation]], [[immune response]]s and in [[intracellular]] [[cell signalling|signalling]] events.<ref name="pmid9151947">{{cite journal |vauthors=Gahmberg CG, Tolvanen M, Kotovuori P | title = Leukocyte adhesion--structure and function of human leukocyte beta2-integrins and their cellular ligands | journal = Eur. J. Biochem. | volume = 245 | issue = 2 | pages = 215–32 |date=April 1997 | pmid = 9151947 | doi = 10.1111/j.1432-1033.1997.00215.x}}</ref> The ICAM family consists of five members, designated ICAM-1 to ICAM-5. They are known to bind to [[leucocyte]] [[integrins]] [[CD11]]/[[CD18]] such as [[LFA-1]] and [[Macrophage-1 antigen]], during [[inflammation]] and in immune responses. In addition, ICAMs may exist in soluble forms in [[Homo sapiens|human]] [[Blood plasma|plasma]], due to activation and [[proteolysis]] mechanisms at [[Cell (biology)|cell]] surfaces. | In [[molecular biology]], '''intercellular adhesion molecules''' ('''ICAMs''') and [[vascular cell adhesion molecule-1]] (VCAM-1) are part of the [[immunoglobulin superfamily]]. They are important in [[inflammation]], [[immune response]]s and in [[intracellular]] [[cell signalling|signalling]] events.<ref name="pmid9151947">{{cite journal |vauthors=Gahmberg CG, Tolvanen M, Kotovuori P | title = Leukocyte adhesion--structure and function of human leukocyte beta2-integrins and their cellular ligands | journal = Eur. J. Biochem. | volume = 245 | issue = 2 | pages = 215–32 |date=April 1997 | pmid = 9151947 | doi = 10.1111/j.1432-1033.1997.00215.x}}</ref> The ICAM family consists of five members, designated ICAM-1 to ICAM-5. They are known to bind to [[Leukocyte|leucocyte]] [[integrins]] [[CD11]]/[[CD18]] such as [[LFA-1]] and [[Macrophage-1 antigen]], during [[inflammation]] and in immune responses. In addition, ICAMs may exist in soluble forms in [[Homo sapiens|human]] [[Blood plasma|plasma]], due to activation and [[proteolysis]] mechanisms at [[Cell (biology)|cell]] surfaces. | ||
Mammalian intercellular adhesion molecules include: | Mammalian intercellular adhesion molecules include: | ||
Latest revision as of 04:40, 17 July 2025
Script error: No such module "Infobox".Template:Template other In molecular biology, intercellular adhesion molecules (ICAMs) and vascular cell adhesion molecule-1 (VCAM-1) are part of the immunoglobulin superfamily. They are important in inflammation, immune responses and in intracellular signalling events.[1] The ICAM family consists of five members, designated ICAM-1 to ICAM-5. They are known to bind to leucocyte integrins CD11/CD18 such as LFA-1 and Macrophage-1 antigen, during inflammation and in immune responses. In addition, ICAMs may exist in soluble forms in human plasma, due to activation and proteolysis mechanisms at cell surfaces.
Mammalian intercellular adhesion molecules include:
References
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