Signal transducing adaptor protein: Difference between revisions

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{{More citations needed|date=November 2007}}
{{More citations needed|date=November 2007}}
[[File:PDB 1u5e EBI.jpg|thumb|Src-associated adaptor protein Skap2 with 1u5e code]]
[[File:PDB 1u5e EBI.jpg|thumb|Src-associated adaptor protein Skap2 with 1u5e code]]
'''Signal transducing adaptor proteins''' (STAPs) are [[protein]]s that are accessory to main proteins in a [[signal transduction]] pathway.<ref>{{cite web|title=Role of Signal Transducing Adaptor Protein (STAP) Family in Chronic Myelogenous Leukemia|url=http://www.bloodjournal.org/content/130/Suppl_1/1583?sso-checked=true|access-date=24 August 2018}}</ref> Adaptor proteins contain a variety of protein-binding modules that link protein-binding partners together and facilitate the creation of larger signaling complexes. These proteins tend to lack any intrinsic enzymatic activity themselves,<ref>{{MeshName|Signal+Transducing+Adaptor+Proteins}}</ref> instead mediating specific [[protein–protein interactions]] that drive the formation of [[Multiprotein complex|protein complexes]]. Examples of adaptor proteins include [[MYD88]],<ref name="entrez">{{cite web | title = Entrez Gene: MYD88 Myeloid differentiation primary response gene (88)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4615}}</ref><ref name="pmid9013863">{{cite journal | vauthors = Bonnert TP, Garka KE, Parnet P, Sonoda G, Testa JR, Sims JE | title = The cloning and characterization of human MyD88: a member of an IL-1 receptor related family | journal = FEBS Letters | volume = 402 | issue = 1 | pages = 81–4 | date = January 1997 | pmid = 9013863 | doi = 10.1016/S0014-5793(96)01506-2 | s2cid = 44843127 | doi-access = free }}</ref> [[Grb2]] and [[SHC1]].
'''Signal transducing adaptor proteins''' (STAPs) are [[protein]]s that are accessory to main proteins in a [[signal transduction]] pathway.<ref>{{cite journal|title=Role of Signal Transducing Adaptor Protein (STAP) Family in Chronic Myelogenous Leukemia| journal=Blood | date=7 December 2017 | volume=130 | issue=Supplement 1 | page=1583 |url=http://www.bloodjournal.org/content/130/Suppl_1/1583?sso-checked=true|access-date=24 August 2018 | last1=Toda | first1=Jun | last2=Ichii | first2=Michiko | last3=Shibayama | first3=Hirohiko | last4=Saito | first4=Hideaki | last5=Kitai | first5=Yuichi | last6=Muromoto | first6=Ryuta | last7=Kashiwakura | first7=Jun-Ichi | last8=Saitoh | first8=Kodai | last9=Matsuda | first9=Tadashi | last10=Oritani | first10=Kenji | last11=Kanakura | first11=Yuzuru }}</ref> Adaptor proteins contain a variety of protein-binding modules that link protein-binding partners together and facilitate the creation of larger signaling complexes. These proteins tend to lack any intrinsic enzymatic activity themselves,<ref>{{MeshName|Signal+Transducing+Adaptor+Proteins}}</ref> instead mediating specific [[protein–protein interactions]] that drive the formation of [[Multiprotein complex|protein complexes]]. Examples of adaptor proteins include [[MYD88]],<ref name="entrez">{{cite web | title = Entrez Gene: MYD88 Myeloid differentiation primary response gene (88)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4615}}</ref><ref name="pmid9013863">{{cite journal | vauthors = Bonnert TP, Garka KE, Parnet P, Sonoda G, Testa JR, Sims JE | title = The cloning and characterization of human MyD88: a member of an IL-1 receptor related family | journal = FEBS Letters | volume = 402 | issue = 1 | pages = 81–4 | date = January 1997 | pmid = 9013863 | doi = 10.1016/S0014-5793(96)01506-2 | s2cid = 44843127 | doi-access = free }}</ref> [[Grb2]] and [[SHC1]].


==Signaling components==
==Signaling components==

Latest revision as of 08:17, 24 June 2025

Template:Short description Template:More citations needed

File:PDB 1u5e EBI.jpg
Src-associated adaptor protein Skap2 with 1u5e code

Signal transducing adaptor proteins (STAPs) are proteins that are accessory to main proteins in a signal transduction pathway.[1] Adaptor proteins contain a variety of protein-binding modules that link protein-binding partners together and facilitate the creation of larger signaling complexes. These proteins tend to lack any intrinsic enzymatic activity themselves,[2] instead mediating specific protein–protein interactions that drive the formation of protein complexes. Examples of adaptor proteins include MYD88,[3][4] Grb2 and SHC1.

Signaling components

Much of the specificity of signal transduction depends on the recruitment of several signalling components such as protein kinases and G-protein GTPases into short-lived active complexes in response to an activating signal such as a growth factor binding to its receptor.

Domains

Adaptor proteins usually contain several domains within their structure (e.g., Src homology 2 (SH2) and SH3 domains) that allow specific interactions with several other specific proteins. SH2 domains recognise specific amino acid sequences within proteins containing phosphotyrosine residues and SH3 domains recognise proline-rich sequences within specific peptide sequence contexts of proteins.

There are many other types of interaction domains found within adaptor and other signalling proteins that allow a rich diversity of specific and coordinated protein–protein interactions to occur within the cell during signal transduction.

Examples of adaptor proteins

Adaptor proteins include:

  • BCAR3 – Breast cancer anti-estrogen resistance protein 3
  • CBL – Casitas B-lineage Lymphoma
  • FRS2 – Fibroblast growth factor receptor substrate 2
  • GAB2 – GRB2-associated binding protein 2
  • GRAP – GRB2-related adaptor protein
  • GRAP2 – GRB2-related adaptor protein 2
  • GRB2 – Growth factor receptor-bound protein 2
  • IRS1 – Insulin receptor substrate 1
  • LDLRAP1 – low-density lipoprotein receptor adaptor protein 1
  • MYD88 - Myeloid differentiation primary response gene 88
  • NCDN - Neurochondrin
  • NCK1 – NCK adaptor protein 1
  • NCK2 – NCK adaptor protein 2
  • NOS1AP – nitric oxide synthase 1 (neuronal) adaptor protein
  • PIK3AP1 – phosphoinositide-3-kinase adaptor protein 1
  • SH2B1 – SH2B adaptor protein 1
  • SH2B2 – SH2B adaptor protein 2
  • SH2B3 – SH2B adaptor protein 3
  • SH2D3A -SH2 domain containing 3A
  • SH2D3C – SH2 domain containing 3C
  • SNTA1 – Syntrophin, alpha 1
  • SHB – Src homology 2 domain containing adaptor protein B
  • SLC4A1AP – solute carrier family 4 (anion exchanger), member 1, adaptor protein

See also

References

Template:Reflist

Further reading

  • TAB2 is an adaptor protein involved in the IL-1 signal transduction pathway: Script error: No such module "Citation/CS1".
  • Good article about adaptor proteins involved in protein kinase C-mediated signal transduction: Script error: No such module "Citation/CS1".
  • A good article regarding the role of adaptor proteins involved with the T-cell antigen receptor: Script error: No such module "Citation/CS1".
  • Signalling discussed with regards to adaptor proteins: Script error: No such module "Citation/CS1".
  1. REDIRECT Template:Signal transduction

Template:Carrier proteins Template:Adaptor proteins Template:Authority control

  1. ↑ Script error: No such module "Citation/CS1".
  2. ↑ Template:MeshName
  3. ↑ Script error: No such module "citation/CS1".
  4. ↑ Script error: No such module "Citation/CS1".
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