imported>InedibleHulk: If you're not careful, the "word" will "lose all meaning".

2023-10-28T05:52:55Z

If you're not careful, the "word" will "lose all meaning".

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{{short description|Known RNA transcripts of DNA whose function is unclear}}
'''Transcripts of unknown function (TUFs)''' is the name that has been suggested for known [[RNA|RNA transcripts]] of [[DNA]] whose function is unclear. Most are probably [[Non-coding RNA|ncRNAs]], such as [[RNAi]] or [[snoRNA]]s, but could also represent a whole new class of ncRNA.<ref name="Gingeras">{{cite journal | last = Gingeras | first = Thomas R. | year = 2007 | title = Origin of phenotypes: Genes and transcripts | journal = Genome Research | volume = 17| issue = 6 | pages = 682–690 | doi = 10.1101/gr.6525007 | pmid = 17567989 | doi-access = free }}</ref> Their [[DNA sequence]]s reside in the [[Intergenic region|intergenic]] or [[intron]]ic regions of the [[genome]], which is often called [[junk DNA]].

== Categories ==
Broadly speaking, TUFs can be classified into three categories:<ref name="Gingeras" />
# TUFs that are complementary to [[Sense (molecular biology)|sense transcripts]] of protein-coding [[gene]]s
# TUFs that are novel [[Protein isoform|isoform]] transcripts of protein-coding genes; this can include expressed [[pseudogene]]s
# TUFs that reside on the same strand as protein-coding genes in the intronic region or entirely in the intergenic region

== References ==
{{reflist}}

{{DEFAULTSORT:Transcript Of Unknown Function}}
[[Category:Molecular genetics]]
[[Category:RNA]]
[[Category:Non-coding RNA]]

Transcript of unknown function - Revision history

imported>InedibleHulk: If you're not careful, the "word" will "lose all meaning".