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{{Short description|Software for inferring bioinformatics split graphs}}
{{Infobox software
| name = SplitsTree
| logo =
| screenshot =
| caption =
| developer = Daniel Huson and David Bryant
| latest release version = 4.17.1
| latest release date = 2021
| latest preview version = 5.3
| latest preview date = 2021
| operating system = Windows, Linux, Mac OS X
| platform =
| genre = [[Bioinformatics]]
| license = Proprietary
| website = {{URL|https://uni-tuebingen.de/fakultaeten/mathematisch-naturwissenschaftliche-fakultaet/fachbereiche/informatik/lehrstuehle/algorithms-in-bioinformatics/software/splitstree/}}
}}
[[File:Heterobranchia tree.png|right|thumb|An example of a [[neighbor-net]] [[phylogenetic network]] generated by SplitsTree v4.6.]]
'''SplitsTree''' is a [[freeware]] program for inferring [[phylogenetic tree]]s, [[phylogenetic network]]s, or, more generally, [[split graphs]], from various types of data such as a [[sequence alignment]], a [[distance matrix]] or a set of trees.<ref name="dhm2001">{{cite journal |last=Dress |first=A. |author2=K. T. Huber|author2-link=Katharina T. Huber |author3=V. Moulton |year=2001 |title= Metric spaces in pure and applied mathematics |journal= Documenta Mathematica |series=Documenta Mathematica Series |volume=2 |pages=121–139 |doi=10.4171/dms/2/5 |doi-access=free |isbn=978-3-98547-042-6 |url=http://www.emis.de/journals/DMJDMV/lsu/dress-huber-multon.pdf }}</ref><ref name="hb2006">{{cite journal |last=Huson |first=D. H. |author2=D. Bryant |year=2006 |title= Application of Phylogenetic Networks in Evolutionary Studies |journal=Mol. Biol. Evol. |volume=23 |issue=2 |pages= 254–267 | doi=10.1093/molbev/msj030 |pmid=16221896 |doi-access=free }}</ref>

==Software==
SplitsTree implements published methods such as [[split (phylogenetics)|split]] decomposition,<ref>{{Cite journal|last1=Bandelt|first1=H. J.|last2=Dress|first2=A. W.|year=1992|title=Split decomposition: a new and useful approach to phylogenetic analysis of distance data|journal=Molecular Phylogenetics and Evolution|volume=1|issue=3|pages=242–252|doi=10.1016/1055-7903(92)90021-8|issn=1055-7903|pmid=1342941|bibcode=1992MolPE...1..242B }}</ref> [[neighbor-net]], consensus networks,<ref>{{Cite book|last1=Holland|first1=Barbara|last2=Moulton|first2=Vincent|date=2003|editor-last=Benson|editor-first=Gary|editor2-last=Page|editor2-first=Roderic D. M.|chapter=Consensus Networks: A Method for Visualising Incompatibilities in Collections of Trees|title=Algorithms in Bioinformatics|volume=2812|series=Lecture Notes in Computer Science|language=en|publisher=Springer Berlin Heidelberg|pages=165–176|doi=10.1007/978-3-540-39763-2_13|isbn=9783540397632}}</ref> super networks methods or methods for computing [[Hybrid (biology)|hybridization]] or simple [[genetic recombination|recombination]] networks. It uses the [[Nexus file|NEXUS file format]]. The splits graph is defined using a special data block (SPLITS block).

== See also ==
*[[Phylogenetic tree viewers]]
*[[Dendroscope]]
*[[MEGAN]]

== References ==
{{Reflist}}

== External links ==
*[https://uni-tuebingen.de/fakultaeten/mathematisch-naturwissenschaftliche-fakultaet/fachbereiche/informatik/lehrstuehle/algorithms-in-bioinformatics/software/splitstree/ SplitsTree homepage] (New Website for informations about SplitsTree)
*[https://software-ab.informatik.uni-tuebingen.de/download/splitstree4/welcome.html Alternative download page] for the latest version (4.15) and manual (June 2019), hosted by the [https://uni-tuebingen.de/en/faculties/faculty-of-science/departments/computer-science/department/ Department of Computer Science] at the [[University of Tübingen|Eberhard Karls University Tübingen]]
*[https://uni-tuebingen.de/en/faculties/faculty-of-science/departments/computer-science/lehrstuehle/algorithmen-der-bioinformatik/ Algorithms in Bioinformatics], Daniel Huson's working group developing SplitsTree and other bioinformatics software
*[http://evolution.genetics.washington.edu/phylip/software.html List of phylogeny software], hosted at the University of Washington
*[http://phylonetworks.blogspot.com/ The Genealogical World of Phylogenetic Networks] provides a wide range of examples for splits graphs, most of which were generated with SplitsTree
*[https://phylnet.univ-mlv.fr/ Who is Who in Phylogenetic Networks] lists software, researchers and literature dealing with phylogenetic networks

[[Category:Phylogenetics software]]

SplitsTree - Revision history

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