imported>Vycl1994 at 04:30, 25 April 2025

2025-04-25T04:30:25Z

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{{Infobox protein family
| Symbol = Spectrin
| Name = Spectrin repeat
| image =PDB 1aj3 EBI.jpg
| width =
| caption = Structure of the spectrin repeat: a left-handed antiparallel triple-helical coiled-coil.<ref name="pmid9356261">{{cite journal |vauthors=Pascual J, Pfuhl M, Walther D, Saraste M, Nilges M |title=Solution structure of the spectrin repeat: a left-handed antiparallel triple-helical coiled-coil |journal=J. Mol. Biol. |volume=273 |issue=3 |pages=740–51 |date=October 1997 |pmid=9356261 |doi=10.1006/jmbi.1997.1344 }}</ref>
| Pfam= PF00435
| Pfam_clan = CL0743
| ECOD = 604.1.1
| InterPro= IPR002017
| SMART=
| PROSITE = PDOC50083
| SCOP = 1aj3
| TCDB =
| CDD = cd00176
| OPM family=
| OPM protein=
| PDB=
}}

'''Spectrin repeats'''<ref name="PUB00005178">{{cite journal |author6-link=Daniel Branton |vauthors=Harrison SC, Yan Y, Winograd E, Viel A, Cronin T, Branton D |title=Crystal structure of the repetitive segments of spectrin |journal=Science |volume=262 |issue=5142 |pages=2027–2030 |year=1993 |pmid=8266097 |doi=10.1126/science.8266097}}</ref> are found in several proteins involved in [[cytoskeleton|cytoskeletal structure]]. These include [[spectrin]], alpha-[[actinin]], [[dystrophin]] and more recently the [[plakin]] family. The spectrin repeat forms a three-[[helix bundle]]. These conform to the rules of the [[heptad repeat]]. Spectrin repeats give rise to linear proteins. This however may be due to sample bias in which linear and rigid structures are more amenable to crystallization. There are hints however, that some proteins harbouring spectrin repeats may also be flexible. This is most likely due to specifically evolved functional purposes.

==Human proteins containing this domain ==
[[ACTN1]]; [[ACTN2]]; [[ACTN3]]; [[ACTN4]]; [[AKAP6]]; [[SYNE3]]; [[CATX-15]]; [[Dystrophin|DMD]];
[[DRP2]]; [[Dystonin|DST]]; [[KALRN]]; [[MACF1]]; [[MCF2L]]; [[SPTA1]]; [[SPTAN1]];
[[SPTB]]; [[SPTBN1]]; [[SPTBN2]]; [[SPTBN4]]; [[SPTBN5]]; [[SYNE1]]; [[SYNE2]];
[[TRIO (protein)|TRIO]]; [[UTRN]];

==References==
{{reflist}}
*{{cite journal|last=Jefferson|first=JJ|author2=Ciatto, C |author3=Shapiro, L |author4=Liem, RK |title=Structural analysis of the plakin domain of bullous pemphigoid antigen1 (BPAG1) suggests that plakins are members of the spectrin superfamily.|journal=Journal of Molecular Biology|year=2007|volume=366|issue=1|pages=244–57|pmid=17161423|doi=10.1016/j.jmb.2006.11.036|pmc=1850962}}
*{{cite journal|last=Grum|first=VL|author2=Li, D |author3=MacDonald, RI |author4=Mondragón, A |title=Structures of two repeats of spectrin suggest models of flexibility.|journal=Cell|year=1999|volume=98|issue=4|pages=523–35|pmid=10481916|doi=10.1016/S0092-8674(00)81980-7|s2cid=1710820|doi-access=free}}

==Further reading==
*{{cite journal |vauthors=Djinovic-Carugo K, Gautel M, Ylänne J, Young P |title=The spectrin repeat: a structural platform for cytoskeletal protein assemblies |journal=FEBS Lett. |volume=513 |issue=1 |pages=119–23 |date=February 2002 |pmid=11911890 |doi= 10.1016/S0014-5793(01)03304-X|s2cid=10581541 |doi-access=free }}
*{{cite journal |vauthors=Pascual J, Castresana J, Saraste M |title=Evolution of the spectrin repeat |journal=BioEssays |volume=19 |issue=9 |pages=811–7 |date=September 1997 |pmid=9297972 |doi=10.1002/bies.950190911 |s2cid=42145758 }}
*{{cite journal|last=Al-Jassar|first=C|author2=Knowles, T |author3=Jeeves, M |author4=Kami, K |author5=Behr, E |author6=Bikker, H |author7=Overduin, M |author8=Chidgey, M |title=The Nonlinear Structure of the Desmoplakin Plakin Domain and the Effects of Cardiomyopathy-Linked Mutations.|journal=Journal of Molecular Biology|date=Jul 2, 2011|pmid=21756917|doi=10.1016/j.jmb.2011.06.047|volume=411|issue=5|pages=1049–61}}

[[Category:Peripheral membrane proteins]]
[[Category:Protein domains]]
[[Category:Protein superfamilies]]

{{membrane-protein-stub}}

Spectrin repeat - Revision history

imported>Vycl1994 at 04:30, 25 April 2025