imported>BD2412: /* Rosenberg Study */Fixing links to disambiguation pages, replaced: PCR → PCR

2022-11-24T00:27:09Z

Rosenberg Study: Fixing links to disambiguation pages, replaced: PCR → PCR

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{{Short description|Type of DNA polymorphism used as genetic markers}}
'''Simple Sequence Length Polymorphisms''' ('''SSLPs''') are used as [[genetic marker]]s with [[Polymerase Chain Reaction|polymerase chain reaction (PCR)]]. An SSLP is a type of [[Polymorphism (biology)|polymorphism]]: a difference in [[DNA]] sequence amongst individuals. SSLPs are repeated sequences over varying base lengths in intergenic regions of deoxyribonucleic acid (DNA). Variance in the length of SSLPs can be used to understand [[genetic variation]] between two individuals in a certain species.<ref>{{cite journal | last=King | first=M.-C. | title=HUMAN GENETICS: Mapping Human History | journal=Science | publisher=American Association for the Advancement of Science (AAAS) | volume=298 | issue=5602 | date=2002-12-20 | issn=0036-8075 | doi=10.1126/science.1080373 | pages=2342–2343 | pmid=12493903| s2cid=84117619 }}</ref>

==Applications==

An example of the usage of SSLPs ([[Microsatellite (genetics)|microsatellites]]) is seen in a study by Rosenberg et al., where SSLPs were used to cluster different continental populations of human beings.<ref name=":0" /> The study was critical to [[Nicholas Wade]]'s New York Times Bestseller, ''[[Before the Dawn: Recovering the Lost History of Our Ancestors]]''.<ref>Wade, Nicholas (2006). ''Before the Dawn: Recovering the Lost History of Our Ancestors''. Penguin Press. {{ISBN|978-1-59420-079-3}}</ref>

==Rosenberg Study==

Rosenberg studied 377 SSLPs in 1000 people in 52 different regions of the world. By using [[Polymerase chain reaction|PCR]] and [[cluster analysis]], Rosenberg was able to group individuals that had the same SSLPs . These SSLPs were extremely useful to the experiment because they do not affect the [[phenotype]]s of the individuals, thus being unaffected by [[natural selection]].<ref name=":0">{{cite journal | last=Rosenberg | first=N. A. | title=Genetic Structure of Human Populations | journal=Science | publisher=American Association for the Advancement of Science (AAAS) | volume=298 | issue=5602 | date=2002-12-20 | issn=0036-8075 | doi=10.1126/science.1078311 | pages=2381–2385 | pmid=12493913| bibcode=2002Sci...298.2381R | s2cid=8127224 }}</ref>

==References==
<references/>

[[Category:Polymorphism (biology)]]

Simple sequence length polymorphism - Revision history

imported>BD2412: /* Rosenberg Study */Fixing links to disambiguation pages, replaced: PCR → PCR