http://debianws.lexgopc.com/wiki143/index.php?action=history&feed=atom&title=Serial_intervalSerial interval - Revision history2026-05-04T22:46:19ZRevision history for this page on the wikiMediaWiki 1.43.1http://debianws.lexgopc.com/wiki143/index.php?title=Serial_interval&diff=3624608&oldid=previmported>AnomieBOT: Dating maintenance tags: {{Cn}}2023-04-11T16:10:31Z<p>Dating maintenance tags: {{Cn}}</p>
<p><b>New page</b></p><div>The '''serial interval''' in the [[epidemiology]] of [[Infectious disease|communicable (infectious) diseases]] is the time between successive cases in a chain of transmission.<ref>Last J.M. (2001) ''A Dictionary of Epidemiology'', [[Oxford University Press]].<br />
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The serial interval is generally estimated from the interval between clinical onsets (if observable), in which case it is the 'clinical onset serial interval'. It could in principle be estimated by the time interval between infection and subsequent transmission. If the typical time from the first person's clinical onset to when they infect another is ''TA'', and the incubation period of a subsequent case is ''IB'', then the clinical onset serial interval is ''TA + IB''. More realistically, the calculation would use the observed frequency distribution of times from onset of a single primary case to that of its associated secondary cases.<ref>{{Cite journal |last1=Fine |first1=P. E. M. |title=The Interval between Successive Cases of an Infectious Disease |doi=10.1093/aje/kwg251 |journal=American Journal of Epidemiology |volume=158 |issue=11 |pages=1039–1047 |year=2003 |pmid=14630599 |pmc= |doi-access=free}}</ref><br />
If the distribution of timing of transmission events during the infectious period is not skewed around its mean, then the average serial interval is calculated as the sum of the average [[Incubation period|latent period]] (from infection to infectiousness) and half the average infectious period.{{cn|date=April 2023}}<br />
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Serial intervals can vary widely, especially for lifelong diseases such as [[HIV|HIV infection]], [[chickenpox]], and [[herpes]]. The serial interval for [[Severe acute respiratory syndrome|SARS]] was 7 days.<ref>{{Cite journal |last1=Lipsitch |first1=M. |last2=Cohen |first2=T. |last3=Cooper |first3=B. |last4=Robins |first4=J. M. |last5=Ma |first5=S. |last6=James |first6=L. |last7=Gopalakrishna |first7=G. |last8=Chew |first8=S. K. |last9=Tan |first9=C. C. |last10=Samore |first10=M. H. |last11=Fisman |first11=D. |last12=Murray |first12=M. |title=Transmission Dynamics and Control of Severe Acute Respiratory Syndrome |doi=10.1126/science.1086616 |journal=Science |volume=300 |issue=5627 |pages=1966–1970 |year=2003 |pmid=12766207 |pmc=2760158 |bibcode=2003Sci...300.1966L |url=https://dash.harvard.edu/bitstream/handle/1/25620506/Transmission%20dynamics%20and%20control%20of%20severe%20acute%20respiratory%20syndrome.pdf?sequence=1}}</ref> For the original strain of [[COVID-19]], a 2020 review of the published literature shows its serial interval to be 4-8 days.<ref>{{Cite journal |doi=10.3390/jcm9040967 |issn=2077-0383 |volume=9 |issue=4 |last1=Park |first1=Minah |last2=Cook |first2=Alex R. |last3=Lim |first3=Jue Tao |last4=Sun |first4=Yinxiaohe |last5=Dickens |first5=Borame L. |title=A Systematic Review of COVID-19 Epidemiology Based on Current Evidence |journal=Journal of Clinical Medicine |date=2020-03-31 |pmid=32244365 |doi-access=free |pmc=7231098 |page=967}}</ref><br />
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Related but distinct quantities include the 'average transmission interval' sum of average latent and infectious period, the '[[incubation period]]' between infection and disease onset, and the 'latent period' between infection and infectiousness.{{cn|date=April 2023}}<br />
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==References==<br />
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{{Concepts in infectious disease}}<br />
{{DEFAULTSORT:Serial Interval}}<br />
[[Category:Epidemiology]]<br />
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