imported>Citation bot: Add: doi-access. | Use this bot. Report bugs. | #UCB_CommandLine

2023-12-03T21:46:51Z

Add: doi-access. | Use this bot. Report bugs. | #UCB_CommandLine

New page

The '''pre-integration complex''' ('''PIC''') is a [[nucleoprotein]] complex of viral [[genetic material]] and associated viral and host proteins which is capable of inserting a viral genome into a host genome. The PIC forms after uncoating of a viral particle after entry into the host cell. In the case of the [[HIV|human immunodeficiency virus]] (HIV), the PIC forms after the Reverse Transcription Complex (RTC) has reverse transcribed the viral RNA into DNA.<ref name=":0">{{cite journal | vauthors = Arhel N | title = Revisiting HIV-1 uncoating | journal = Retrovirology | volume = 7 | issue = 1 | pages = 96 | date = November 2010 | pmid = 21083892 | pmc = 2998454 | doi = 10.1186/1742-4690-7-96 | url = | doi-access = free }}</ref> The PIC consists of viral proteins (including [[Vpr]], [[Viral matrix protein|matrix]] and [[integrase]]), host proteins (including [[Barrier to autointegration factor 1]]) and the viral DNA.<ref name=":0" /> The PIC enters the cellular nucleus through the [[nuclear pore complex]] without disrupting the [[nuclear envelope]], thus allowing HIV and related [[retroviruses]] to replicate in non-dividing cells.<ref>{{cite journal | vauthors = Piller SC, Caly L, Jans DA | title = Nuclear import of the pre-integration complex (PIC): the Achilles heel of HIV? | journal = Current Drug Targets | volume = 4 | issue = 5 | pages = 409–29 | date = July 2003 | pmid = 12816349 | doi = 10.2174/1389450033490984 }}</ref><ref>{{cite journal | vauthors = De Rijck J, Vandekerckhove L, Christ F, Debyser Z | title = Lentiviral nuclear import: a complex interplay between virus and host | journal = BioEssays | volume = 29 | issue = 5 | pages = 441–51 | date = May 2007 | pmid = 17450594 | doi = 10.1002/bies.20561 | s2cid = 46411712 }}</ref> Following nuclear entry, the PIC's DNA payload may be integrated into the host [[DNA]] as a "[[provirus]]".<ref>{{cite journal | vauthors = Smith JA, Nunnari G, Preuss M, Pomerantz RJ, Daniel R | title = Pentoxifylline suppresses transduction by HIV-1-based vectors | journal = Intervirology | volume = 50 | issue = 5 | pages = 377–86 | year = 2007 | pmid = 17938572 | doi = 10.1159/000109752 | s2cid = 34357038 }}</ref>

== See also ==
*[[HIV]]
*[[Barrier to autointegration factor 1]]

== References ==
{{Reflist}}

== External links ==
*http://www.mcld.co.uk/hiv/?q=preintegration%20complex
* {{cite journal |vauthors=Suzuki Y, Craigie R | title = The road to chromatin - nuclear entry of retroviruses | journal = Nature Reviews. Microbiology | volume = 5 | issue = 3 | pages = 187–96 | date = March 2007 | pmid = 17304248 | doi = 10.1038/nrmicro1579 | s2cid = 6789517 |ref=none}}

{{DEFAULTSORT:Pre-Integration Complex}}
[[Category:Virology]]

{{biology-stub}}

Pre-integration complex - Revision history

imported>Citation bot: Add: doi-access. | Use this bot. Report bugs. | #UCB_CommandLine