imported>GreenC bot: Rescued 1 archive link; reformat 2 links. Wayback Medic 2.5

2020-08-25T05:05:14Z

Rescued 1 archive link; reformat 2 links. Wayback Medic 2.5

New page

'''PMHC cellular microarrays''' are a type of [[cellular microarray]] that has been spotted with pMHC complexes peptide-[[MHC class I]] or peptide-[[MHC class II]].

These biochips can be used to interrogate immune cells, particularly antigen-specific [[T cell]]s, from clinical samples for what they are capable of
recognizing. They can also be co-spotted with other molecules, such as antibodies that capture cytokines, allowing for high-throughput functional
analysis of the captured T cells. Molecules spotted on a pMHC cellular microarray can be classified as capture molecules, detector molecules and effector
molecules.

They were developed by Daniel Chen, Yoav Soen, Dan Kraft, Pat Brown and Mark Davis
at [[Stanford University Medical Center]].

==References==

Chen DS, Davis MM (2006) Molecular and functional analysis using live cell microarrays. Curr Opin Chem Biol 10:28-34

Chen DS, Soen Y, Stuge TB, Lee PP, Weber JS, Brown PO, Davis MM (2005) Marked Differences in Human Melanoma Antigen-Specific T Cell Responsiveness after Vaccination Using a Functional Microarray. PLoS Med 2: 10: e265 ([https://archive.today/20130113063447/http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0020265]) {{open access}}

Soen Y., Chen D. S., Kraft D. L., Davis M. M. and Brown P.O. (2003) Detection and characterization of cellular immune responses using peptide-MHC microarrays. PLoS Biol. 1: E65 (http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0000065) {{open access}}

Chen DS, Davis MM (2005) Cellular immunotherapy: Antigen recognition is just the beginning. Springer Semin Immunopathol 27:119–127

Soen Y, Chen DS, Stuge TB, Weber JS, Lee PP, et al. (2004) A novel cellular microarray identifies functional deficiences in tumor-specific T cell responses. J Clin Oncol 22:2510

[[Category:Microarrays]]

PMHC cellular microarray - Revision history

imported>GreenC bot: Rescued 1 archive link; reformat 2 links. Wayback Medic 2.5