http://debianws.lexgopc.com/wiki143/index.php?action=history&feed=atom&title=MyelopoiesisMyelopoiesis - Revision history2026-06-02T02:31:53ZRevision history for this page on the wikiMediaWiki 1.43.1http://debianws.lexgopc.com/wiki143/index.php?title=Myelopoiesis&diff=7657981&oldid=previmported>Chris the speller: /* top */replaced: "C" shaped → C-shaped2024-01-10T05:53:02Z<p><span class="autocomment">top: </span>replaced: "C" shaped → C-shaped</p>
<p><b>New page</b></p><div>{{Short description|Production of bone marrow and blood cells}}<br />
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In [[hematology]], '''myelopoiesis''' in the broadest [[word sense|sense]] of the term is the production of [[bone marrow]] and of all [[cell (biology)|cells]] that arise from it, namely, all [[blood cell]]s.<ref>''McGraw-Hill Concise Dictionary of Modern Medicine''. S.v. "myelopoiesis." Retrieved 2022-03-15 from https://medical-dictionary.thefreedictionary.com/myelopoiesis</ref> In a narrower sense, myelopoiesis also refers specifically to the regulated formation of [[myeloid]] leukocytes ([[myelocyte]]s), including [[eosinophilic|eosinophilic granulocytes]], [[basophilic|basophilic granulocytes]], [[neutrophilic|neutrophilic granulocytes]], and [[monocytes]].<ref>{{Cite journal |last1=Schultze |first1=Joachim L. |last2=Mass |first2=Elvira |last3=Schlitzer |first3=Andreas |date=2019-02-19 |title=Emerging Principles in Myelopoiesis at Homeostasis and during Infection and Inflammation |journal=Immunity |language=English |volume=50 |issue=2 |pages=288–301 |doi=10.1016/j.immuni.2019.01.019 |issn=1074-7613 |pmid=30784577|doi-access=free }}</ref><br />
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The [[CFU-GEMM|common myeloid progenitor]] can [[cellular differentiation|differentiate]] in the bone marrow into [[red blood cell]]s and [[megakaryocyte]]s (leading to [[platelet]]s) as well as [[mast cell]]s and [[myeloblast]]s, the latter leading to the [[myelocyte|myelocytic]] line ([[granulocyte]]s) and to [[monocyte]]s, [[macrophage]]s, and [[dendritic cell]]s of the [[innate immune system]]. The granulocytes, also called polymorphonuclear leukocytes because of their multilobed nuclei, are three short lived cell types including [[eosinophil]]s, [[basophil]]s, and [[neutrophil]]s. A granulocyte differentiates into a distinct cell type by a process called [[granulopoiesis]]. In this process it first transforms from a common [[myeloblast]] (myeloid progenitor) to a common promyelocyte. This promyelocyte gives rise to a unique myelocyte that for the first time can be classified as an eosinophil, basophil, or neutrophil progenitor based on the histological staining affinity (eosinophilic, basophilic, or neutral granules).<ref>Junqueira, Carneiro. Basic Histology, Text and Atlas.McGraw-Hill Companies. 2005. {{ISBN|978-0-07-144116-2}}</ref> The unique myelocyte next differentiates into a metamyelocyte and then a [[band cell]], with a C-shaped nucleus, before becoming a mature eosinophil, basophil, or neutrophil. Macrophages come from monoblast progenitors that differentiate into [[promonocytes]], which mature into [[monocytes]]. Monocytes eventually enter the tissues and become [[macrophages]].{{cn|date=December 2021}}<br />
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==References==<br />
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==External links==<br />
* {{MeshName|Myelopoiesis}}<br />
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{{Blood physiology}}<br />
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[[Category:Hematopoiesis]]<br />
[[Category:Histology]]<br />
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{{hematology-stub}}</div>imported>Chris the speller