http://debianws.lexgopc.com/wiki143/index.php?action=history&feed=atom&title=Integrin_alpha_2b Integrin alpha 2b - Revision history 2026-05-12T22:10:57Z Revision history for this page on the wiki MediaWiki 1.43.1 http://debianws.lexgopc.com/wiki143/index.php?title=Integrin_alpha_2b&diff=5729302&oldid=prev imported>OAbot: Open access bot: doi updated in citation with #oabot. 2025-06-02T03:01:51Z <p><a href="https://en.wikipedia.org/wiki/OABOT" class="extiw" title="wikipedia:OABOT">Open access bot</a>: doi updated in citation with #oabot.</p> <p><b>New page</b></p><div>{{cs1 config|name-list-style=vanc}}<br /> {{Short description|Mammalian protein found in Homo sapiens}}<br /> {{Infobox_gene}}<br /> &#039;&#039;&#039;Integrin alpha-IIb&#039;&#039;&#039; is a [[protein]] that in humans is encoded by the &#039;&#039;ITGA2B&#039;&#039; [[gene]]. ITGA2B, also known as [[Cluster of differentiation|CD]]41, encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibrinogen receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in [[Glanzmann&#039;s thrombasthenia|thrombasthenia]]. At least 38 disease-causing mutations in this gene have been discovered.&lt;ref name = &quot;Šimčíková_2019 - supplementary table S7&quot;&gt;{{cite journal | vauthors = Šimčíková D, Heneberg P | title = Refinement of evolutionary medicine predictions based on clinical evidence for the manifestations of Mendelian diseases | journal = Scientific Reports | volume = 9 | issue = 1 | pages = 18577 | date = December 2019 | pmid = 31819097 | pmc = 6901466 | doi = 10.1038/s41598-019-54976-4| bibcode = 2019NatSR...918577S }}&lt;/ref&gt; In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.&lt;ref&gt;{{cite web | title = Entrez Gene: ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&amp;Cmd=ShowDetailView&amp;TermToSearch=3674}}&lt;/ref&gt;<br /> <br /> ==Interactions==<br /> ITGA2B has been shown to [[Protein-protein interaction|interact]] with [[AUP1]]&lt;ref name=pmid12042322&gt;{{cite journal |last=Kato |first=Atsushi |author2=Kawamata Norihiko |author3=Tamayose Kenji |author4=Egashira Motoki |author5=Miura Rika |author6=Fujimura Tsutomu |author7=Murayama Kimie |author8=Oshimi Kazuo |date=Aug 2002 |title=Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3 |journal=J. Biol. Chem. |volume=277 |issue=32 |pages=28934–41 |location = United States| issn = 0021-9258| pmid = 12042322 |doi = 10.1074/jbc.M204340200 |doi-access=free }}&lt;/ref&gt; and [[CLNS1A]].&lt;ref name=pmid15075326&gt;{{cite journal |last=Larkin |first=Deirdre |author2=Murphy Derek |author3=Reilly Dermot F |author4=Cahill Martha |author5=Sattler Ellen |author6=Harriott Pat |author7=Cahill Dolores J |author8=Moran Niamh |date=Jun 2004 |title=ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation |journal=J. Biol. Chem. |volume=279 |issue=26 |pages=27286–93 |location = United States| issn = 0021-9258| pmid = 15075326 |doi = 10.1074/jbc.M402159200 |doi-access=free }}&lt;/ref&gt;<br /> <br /> ==See also==<br /> * [[Cluster of differentiation]]<br /> * [[Glycoprotein IIb/IIIa]]<br /> <br /> ==References==<br /> {{reflist}}<br /> <br /> ==Further reading==<br /> {{refbegin | 2}}<br /> <br /> *{{cite journal | author=Bray PF |title=Inherited diseases of platelet glycoproteins: considerations for rapid molecular characterization. |journal=Thromb. Haemost. |volume=72 |issue= 4 |pages= 492–502 |year= 1995 |pmid= 7878622 }}<br /> *{{cite journal |vauthors=Naik UP, Parise LV |title=Structure and function of platelet alpha IIb beta 3. |journal=Curr. Opin. Hematol. |volume=4 |issue= 5 |pages= 317–22 |year= 1997 |pmid= 9288464 |doi= 10.1097/00062752-199704050-00004}}<br /> *{{cite journal |vauthors=Porter JC, Hogg N |title=Integrins take partners: cross-talk between integrins and other membrane receptors. |journal=Trends Cell Biol. |volume=8 |issue= 10 |pages= 390–6 |year= 1999 |pmid= 9789327 |doi=10.1016/S0962-8924(98)01344-0 }}<br /> *{{cite journal | author=Lincoff AM |title=Trials of platelet glycoprotein IIb/IIIa receptor antagonists during percutaneous coronary revascularization. |journal=Am. J. Cardiol. |volume=82 |issue= 8B |pages= 36P–42P |year= 1998 |pmid= 9809890 |doi=10.1016/S0002-9149(98)00662-6 }}<br /> *{{cite journal | author=Bennett JS |title=Platelet-fibrinogen interactions. |journal=Ann. N. Y. Acad. Sci. |volume=936 |pages= 340–54 |year= 2001 |issue=1 |pmid= 11460491 |doi=10.1111/j.1749-6632.2001.tb03521.x |bibcode=2001NYASA.936..340B |s2cid=25431334 }}<br /> *{{cite journal |vauthors=Plow EF, Cierniewski CS, Xiao Z, etal |title=AlphaIIbbeta3 and its antagonism at the new millennium. |journal=Thromb. Haemost. |volume=86 |issue= 1 |pages= 34–40 |year= 2002 |pmid= 11487023 |doi= 10.1055/s-0037-1616198|s2cid=74389210 }}<br /> *{{cite journal |vauthors=Quinn MJ, Byzova TV, Qin J, etal |title=Integrin alphaIIbbeta3 and its antagonism. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=23 |issue= 6 |pages= 945–52 |year= 2004 |pmid= 12637342 |doi= 10.1161/01.ATV.0000066686.46338.F1 |doi-access= free }}<br /> *{{cite journal | author=Fullard JF |title=The role of the platelet glycoprotein IIb/IIIa in thrombosis and haemostasis. |journal=Curr. Pharm. Des. |volume=10 |issue= 14 |pages= 1567–76 |year= 2004 |pmid= 15134555 |doi=10.2174/1381612043384682 }}<br /> *{{cite journal |vauthors=Watson SP, Auger JM, McCarty OJ, Pearce AC |title=GPVI and integrin alphaIIb beta3 signaling in platelets. |journal=J. Thromb. Haemost. |volume=3 |issue= 8 |pages= 1752–62 |year= 2005 |pmid= 16102042 |doi= 10.1111/j.1538-7836.2005.01429.x |s2cid=42666713 |doi-access=free }}<br /> *{{cite journal | author=Bennett JS |title=Structure and function of the platelet integrin alphaIIbbeta3. |journal=J. Clin. Invest. |volume=115 |issue= 12 |pages= 3363–9 |year= 2006 |pmid= 16322781 |doi= 10.1172/JCI26989 | pmc=1297263 }}<br /> *{{cite journal |vauthors=Ma YQ, Qin J, Plow EF |title=Platelet integrin alpha(IIb)beta(3): activation mechanisms. |journal=J. Thromb. Haemost. |volume=5 |issue= 7 |pages= 1345–52 |year= 2007 |pmid= 17635696 |doi= 10.1111/j.1538-7836.2007.02537.x |s2cid=12983526 |doi-access=free }}<br /> <br /> {{refend}}<br /> <br /> ==External links==<br /> * {{MeshName|CD41+Antigen}}<br /> * {{PDBe-KB2|P08514|Human Integrin alpha-IIb}}<br /> <br /> {{PDB Gallery|geneid=3674}}<br /> {{Clusters of differentiation}}<br /> {{Coagulation}}<br /> <br /> [[Category:Clusters of differentiation]]<br /> [[Category:Integrins]]<br /> <br /> {{membrane-protein-stub}}</div> imported>OAbot