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{| id="drugInfoBox" style="float: right; clear: right; margin: 0 0 0.5em 1em; background: #ffffff;" class="toccolours" border=0 cellpadding=0 align=right width="240px"
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| align="center" colspan="2" | [[Image:DR Illustration.PNG|240px|Illustration of an HLA-DR (Human MHC class II) antigen receptor with bound antigen]]
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| align="center" colspan="2" | <div style="font-size:medium; line-height:120%;">major histocompatibility complex, class II, DR10</div>
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| bgcolor="#e7dcc3" | Haplotypes groups
| bgcolor="#eeeeee" | DQA*01:DRB1*1001
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| colspan="2" bgcolor="#dddddd" | '''Structure''' (See [[HLA-DR]])
|-style="background:#f8f8f8"
| bgcolor="#dddddd" | '''Identifiers'''|| align="center" | <div style="font-size:medium; line-height:120%;">alpha ''*0101''</div>
|-
| bgcolor="#e7dcc3" | [[Human Genome Organisation|Symbol(s)]]
| bgcolor="#eeeeee" | [http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=HGNC4947 HLA-DRA]{{Dead link|date=January 2020 |bot=InternetArchiveBot |fix-attempted=yes }}
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| bgcolor="#e7dcc3" | [[European Bioinformatics Institute|EBI-HLA]]
| bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRA*0101 DRA*0101]
|-style="background:#f8f8f8"
| bgcolor="#dddddd" | '''Identifiers'''|| align="center" | <div style="font-size:medium; line-height:120%;">beta 1 ''*1001''</div>
|-
| bgcolor="#e7dcc3" | [[Human Genome Organisation|Symbol(s)]]
| bgcolor="#eeeeee" | [http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=4953 HLA-DRB1]{{Dead link|date=January 2020 |bot=InternetArchiveBot |fix-attempted=yes }}
|-
| bgcolor="#e7dcc3" | [[European Bioinformatics Institute|EBI-HLA]]
| bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB1*1001 DRB1*1001]
|-
| colspan="2" bgcolor="#dddddd" | '''Shared data'''
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| bgcolor="#e7dcc3" | [[Locus (genetics)|Locus]]
| bgcolor="#eeeeee" | [[Chromosome 6 (human)|chr.6]] ''[https://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?chromosome=6p21.31 6p21.31]''
|-
|}

'''HLA-DR10''' (DR10) is a [[Human leukocyte antigen|HLA]]-[[HLA-DR|DR]] serotype that recognizes the DRB1*1001 gene product.

==Serology==
{| border="0" cellspacing="0" cellpadding="0" align="center" style="text-align:center; background:#ffffff; margin-right: 1em; border:2px #e0e0ff solid;"
|+ DR10 serotype recognition of the DRB1*1001 allele gene product<ref>[http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA]</ref>
|- style="background:#f0f0ff"
| style="width:60px" | DRB1* || style="width:60px" | '''DR10'''
| style="width:60px" | DR1 || style="width:60px" | || style="width:60px" | Sample
|- style="background:#f0f0ff"
| allele || % || % || % || size (N)
|-
| style = "background:#e8e8f8" | 1001 || 90 || 4 || || 894
|-
|}

The serological reaction of DR10 is relatively good.

==Disease associations==

===By serotype===
DR10 serotype or cognate alleles are associated with: Lichen planus<ref>{{cite journal |vauthors=White A, Rostom A | title = HLA antigens in Arabs with lichen planus. | journal = Clinical and Experimental Dermatology | volume = 19 | issue = 3 | pages = 236–7 | year = 1994 | pmid = 8033385 | doi = 10.1111/j.1365-2230.1994.tb01174.x| s2cid = 27001518 }}</ref>

===By allele===
'''DRB1*1001''' is associated with [[ovarian cancer]]<ref>{{cite journal |vauthors=Kübler K, Arndt P, Wardelmann E, Krebs D, Kuhn W, van der Ven K | title = HLA-class II haplotype associations with ovarian cancer. | journal = Int J Cancer | volume = 119 | issue = 12 | pages = 2980–5 | year = 2006 | pmid = 17016821 | doi = 10.1002/ijc.22266| doi-access = free }}</ref> and invasive squamous cell [[cervical cancer]] (SCC)<ref>{{cite journal |vauthors=Madeleine M, [[Babette Brumback|Brumback B]], Cushing-Haugen K, Schwartz S, Daling J, Smith A, Nelson J, Porter P, Shera K, McDougall J, Galloway D | title = Human leukocyte antigen class II and cervical cancer risk: a population-based study. | journal = J Infect Dis | volume = 186 | issue = 11 | pages = 1565–74 | year = 2002 | pmid = 12447731 | doi = 10.1086/345285| doi-access = free }}</ref>

==Extended linkage==
'''DRB1*1001:DQA1*01:DQB1*05''' haplotype: Rheumatoid arthritis<ref>{{cite journal |vauthors=Pascual M, Nieto A, López-Nevot M, Ramal L, Matarán L, Caballero A, Alonso A, Martín J, Zanelli E | title = Rheumatoid arthritis in southern Spain: toward elucidation of a unifying role of the HLA class II region in disease predisposition. | journal = Arthritis Rheum | volume = 44 | issue = 2 | pages = 307–14 | year = 2001 | pmid = 11229460 | doi = 10.1002/1529-0131(200102)44:2<307::AID-ANR47>3.0.CO;2-K| doi-access = free }}</ref> The primary involvement appears to be DR10.

==Genetic Linkage==
{| id="drugInfoBox" style="float: right; clear: right; margin: 0 0 0.5em 1em; background: #ffffff;" class="toccolours" border=0 cellpadding=0 align=left width="240px"
|-style="background:#f8f8f8"
|align="center" colspan="4" | <div style="font-size:medium; line-height:120%;">DR10 Haplotypes</div>
|-style="background:#f8f8f8"
| bgcolor="#dddddd"|
! bgcolor="#dddddd"| DRA !! bgcolor="#dddddd"| DRB1 !! bgcolor="#dddddd" |
|-style="background:#f8f8f8"
| rowspan = "1" bgcolor="#e7dcc3" | Haplotypes
| bgcolor="#eeeeee"| *0101 || bgcolor="#eeeeee"| *1001 || bgcolor="#eeeeee" |
|-style="background:#f8f8f8"
| bgcolor="#dddddd"|
! bgcolor="#dddddd"| DQA1 !! bgcolor="#dddddd"| DQB1 !! bgcolor="#dddddd" | DRB1
|-
| bgcolor="#e7dcc3" | Haplotypes
| bgcolor="#eeeeee"| *0101 || bgcolor="#eeeeee"| *0501 || bgcolor="#eeeeee" | *1001
|-style="background:#f8f8f8"
| bgcolor="#dddddd"|
! bgcolor="#dddddd"| HLA-A !! bgcolor="#dddddd"| HLA-B !! bgcolor="#dddddd" | DRB1
|-
| bgcolor="#e7dcc3" | Haplotypes
| bgcolor="#eeeeee"| *0000 || bgcolor="#eeeeee"| *0000 || bgcolor="#eeeeee" | *1001
|-
|}

HLA-DR10 is not genetically linked to DR51, DR52 or DR53, but is linked to [[HLA-DQ1]] and [[HLA-DQ5|DQ5]] serotypes. One haplotype found in caucasians is the HLA-A1-B37-Cw6-DR10-DQ5.

==References==
{{reflist}}
{{DR serotypes}}

{{DEFAULTSORT:Hla-Dr10}}
[[Category:HLA-DR haplotypes|1]]

HLA-DR10 - Revision history

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