http://debianws.lexgopc.com/wiki143/index.php?action=history&feed=atom&title=EsperamicinEsperamicin - Revision history2026-06-01T23:16:07ZRevision history for this page on the wikiMediaWiki 1.43.1http://debianws.lexgopc.com/wiki143/index.php?title=Esperamicin&diff=7785539&oldid=previmported>Boghog: removed duplicate parameter2024-10-21T05:55:59Z<p>removed duplicate parameter</p>
<p><b>New page</b></p><div>{{cs1 config|name-list-style=vanc|display-authors=6}}<br />
{{chembox<br />
|Verifiedfields = changed<br />
|Watchedfields = changed<br />
|verifiedrevid = 399920724<br />
|Name = Esperamicin A1<br />
|ImageFile=Esperamicin.png<br />
|ImageSize=230px<br />
|ImageAlt = Structural formula of esperamicin A1<br />
|ImageFile1 = Esperamicin A1 3D spacefill.png<br />
|ImageAlt1 = Ball-and-stick model of the Esperamicin A1 molecule<br />
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<br />
The '''esperamicins''' are [[chromoprotein]] [[enediyne]] [[Chemotherapy#Cytotoxic antibiotics|antitumor antibiotics]] of bacterial origin. Esperamicin A1 is the most well studied compound in this class. Esperamcin A1 and the related enediyne [[calicheamicin]] are the two most potent antitumor agents known.<ref>[http://jlstasal.myweb.uga.edu/CaliEsp.htm Calicheamicin and Esperamicin are the two most potent antitumor agents known to man], Univ Of Georgia Chem 4500 {{webarchive |url=https://web.archive.org/web/20080921160531/http://jlstasal.myweb.uga.edu/CaliEsp.htm |date=September 21, 2008 }}</ref> The esperamicins are extremely toxic DNA splicing compounds.<ref>{{cite journal | vauthors = Long BH, Golik J, Forenza S, Ward B, Rehfuss R, Dabrowiak JC, Catino JJ, Musial ST, Brookshire KW, Doyle TW | title = Esperamicins, a class of potent antitumor antibiotics: mechanism of action | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 86 | issue = 1 | pages = 2–6 | date = January 1989 | pmid = 2643098 | pmc = 286391 | doi = 10.1073/pnas.86.1.2 | doi-access = free | bibcode = 1989PNAS...86....2L }}</ref><br />
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Oxygen and active oxygen-radical scavengers have no significant influence upon [[DNA replication|DNA]] strand breakage by esperamicin, but the cleavage of DNA by esperamicin is greatly accelerated in the presence of [[thiol]] compounds. The preferential cutting sites of esperamicin are at [[thymidylate]] residues, and the frequency of [[nucleobase]] attacked (T greater than C greater than A greater than G) is different from that of calicheamicin (C much greater than T greater than A = G), [[neocarzinostatin]] (T greater than A greater than C greater than G), or [[bleomycin]] (C greater than T greater than A greater than G).<ref>{{cite journal | vauthors = Sugiura Y, Uesawa Y, Takahashi Y, Kuwahara J, Golik J, Doyle TW | title = Nucleotide-specific cleavage and minor-groove interaction of DNA with esperamicin antitumor antibiotics | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 86 | issue = 20 | pages = 7672–7676 | date = October 1989 | pmid = 2813351 | pmc = 298132 | doi = 10.1073/pnas.86.20.7672 | doi-access = free | bibcode = 1989PNAS...86.7672S }}</ref><br />
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== References ==<br />
{{reflist}}<br />
<br />
{{Enediynes}}<br />
<br />
[[Category:Antibiotics]]<br />
[[Category:Cancer research]]<br />
[[Category:Enediynes]]<br />
[[Category:Isopropylamino compounds]]<br />
[[Category:Carbamates]]<br />
[[Category:Secondary alcohols]]<br />
[[Category:Amines]]<br />
[[Category:Phenol ethers]]<br />
[[Category:Ethers]]<br />
[[Category:Thioethers]]<br />
[[Category:Alkene derivatives]]<br />
[[Category:Anilides]]<br />
[[Category:Benzoate esters]]<br />
[[Category:Methyl esters]]<br />
[[Category:Ketones]]<br />
[[Category:Ten-membered rings]]</div>imported>Boghog