imported>Jevansen: Moving from Category:Pan American Games medalists in athletics (track and field) to Category:Pan American Games bronze medalists in athletics (track and field) using Cat-a-lot

2025-06-11T02:24:39Z

Moving from Category:Pan American Games medalists in athletics (track and field) to Category:Pan American Games bronze medalists in athletics (track and field) using Cat-a-lot

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{{Short description|Canadian runner and pharmacologist (1945–2022)}}
{{Other people|David Bailey}}
{{Infobox sportsperson
|birth_date={{birth date|1945|3|17}}
|birth_place= [[Toronto, Ontario]], Canada
|death_date={{death date and age|2022|8|27|1945|3|17}}
|death_place= [[London, Ontario]], Canada
|spouse=Barbara Bailey
|children=3
|medaltemplates={{MedalSport | Men's [[Athletics (sport)|Athletics]]}}
{{MedalCountry | {{CAN}} }}
{{MedalCompetition|[[Pan American Games]]}}
{{MedalBronze| [[Athletics at the 1967 Pan American Games|1967 Winnipeg]] | 1.500 metres}}
{{MedalCompetition|[[World University Games]]}}
{{MedalSilver| [[Athletics at the 1967 Summer Universiade|1967 Tokyo]] | 1.500 metres}}
}}

'''David George Bailey''' (March 17, 1945 – August 27, 2022) was a Canadian [[track and field]] [[Athletics (sport)|athlete]], and subsequently a recognized [[pharmacologist]], who pioneered the research of [[grapefruit–drug interactions]].

==Athletic career==
Bailey represented Canada at the [[1968 Summer Olympics]] in the men's 1,500 metres.<ref>{{Cite web |title=David Bailey |url=https://olympics.com/en/athletes/david-bailey |access-date=2022-09-23 |website=International Olympic Committee |archive-date=2022-09-23 |archive-url=https://web.archive.org/web/20220923155627/https://olympics.com/en/athletes/david-bailey |url-status=live }}</ref><ref>{{Cite web |title=David Bailey |url=https://olympic.ca/team-canada/david-bailey/ |access-date=2022-09-23 |website=Team Canada - Official Olympic Team Website |date=18 September 2011 |language=en-US |archive-date=2021-10-19 |archive-url=https://web.archive.org/web/20211019114033/https://olympic.ca/team-canada/david-bailey/ |url-status=live }}</ref> He was the first Canadian to run the mile in less than 4 minutes (3:59.1) in San Diego, CA on June 11, 1966 and the first Canadian to run the mile in less than 4 minutes in Canada (3:57.7) in Toronto on July 22, 1967.<ref>{{Cite web |title=David Bailey honored as first Canadian to run a Mile in under 4 minutes |url=https://bringbackthemile.com/news/detail/david_bailey_honored_as_first_canadian_to_run_a_mile_in_under_4_minutes |access-date=2022-09-23 |website=Bring Back the Mile |archive-date=2021-11-27 |archive-url=https://web.archive.org/web/20211127204709/https://www.bringbackthemile.com/news/detail/david_bailey_honored_as_first_canadian_to_run_a_mile_in_under_4_minutes |url-status=live }}</ref> A resident of [[North York|North York, Ontario]], he won the bronze medal in this event at the [[1967 Pan American Games]] and the silver medal in this event at the [[Athletics at the 1967 Summer Universiade|1967 World University Games]]. He was two-time Canadian Universities Track and Field Athlete of Year (1965, 1967) and two-time inductee into the University of Toronto Sports Hall of Fame (individually 1998 and team 2003). He was a member of 9 Canadian national track and field teams, competing at:
* [[Athletics at the 1965 Summer Universiade – Men's 1500 metres|World University Games]], Budapest 1965,
* [[Athletics at the 1966 Commonwealth Games|Commonwealth Games]], Kingston, Jamaica, 1966,
* [[Athletics at the 1967 Pan American Games – Men's 1500 metres|Pan American Games]], Winnipeg, 1967,
* Commonwealth vs. USA, Los Angeles, 1967,
* [[Athletics at the 1967 Summer Universiade – Men's 1500 metres|World University Games]], Tokyo 1967,
* Pre-Olympic Games, Mexico City, 1967,
* Soviet Union Tour, 1968,
* European Tour, 1968,
* [[Athletics at the 1968 Summer Olympics – Men's 1500 metres|Olympic Games]], Mexico City, 1968.

==Academic career==
Bailey completed undergraduate studies in Pharmacy (1968) and graduate work in Pharmacology (M.Sc. 1970; Ph.D. 1973) at the [[University of Toronto]]. After post-doctoral training in Pharmacology at the [[University of Saskatchewan]] and work in drug development for the pharmaceutical industry, he returned to academia in 1986 at the [[University of Western Ontario]], Canada. He was a full Professor in the Departments of Physiology & Pharmacology and Medicine. His research focused on mechanistic and translational clinical pharmacological investigations related to drug interactions.

Bailey's notable publication of [[grapefruit–drug interactions]]<ref>{{cite journal | last1=Bailey | first1=Dg | last2=Spence | first2=Jd | last3=Munoz | first3=C. | last4=Arnold | first4=J.M.O. | title=Interaction of citrus juices with felodipine and nifedipine | journal=The Lancet | publisher=Elsevier BV | volume=337 | issue=8736 | year=1991 | issn=0140-6736 | doi=10.1016/0140-6736(91)90872-m | pages=268–269| pmid=1671113 | s2cid=37137655 }}</ref> has been cited more than 300 times. Grapefruit decreased drug metabolism in humans, which likely represented the first clinical example of a food producing such an effect. Clinically, the concern is that a single judicious amount of grapefruit ingested even many hours beforehand would noticeably boost oral drug bioavailability and cause overdose toxicity. Research findings have demonstrated that grapefruit produced a clinically relevant interaction with more than 40 medications. Formal product information for a number of highly prescribed or essential medications now warn about the risk of a grapefruit-induced adverse drug interaction. A label stating, "Do NOT take with Grapefruit Juice" is often affixed to prescription vials.

Bailey's research was prominently discussed in such prestigious journals as ''[[Nature Medicine]]''<ref name=Aronson2001>{{cite journal | last=Aronson | first=J. K. | title=Forbidden fruit | journal=Nature Medicine | publisher=Springer Science and Business Media LLC | volume=7 | issue=1 | year=2001 | issn=1078-8956 | doi=10.1038/83312 | pages=29–30| pmid=11135611 | s2cid=27805033 }}</ref> and the ''[[New England Journal of Medicine]]''.<ref name=Wilkinson2005>{{cite journal | last=Wilkinson | first=Grant R. | title=Drug Metabolism and Variability among Patients in Drug Response | journal=New England Journal of Medicine | publisher=Massachusetts Medical Society | volume=352 | issue=21 | date=May 26, 2005 | issn=0028-4793 | doi=10.1056/nejmra032424 | pages=2211–2221| pmid=15917386 }}</ref> A review article of his on the topic of grapefruit–drug interactions was republished in a special 2004 Anniversary Edition of the ''[[British Journal of Clinical Pharmacology]]'', which reprinted only 14 publications that were considered of major importance over the past 30 years. A research study in the elderly received the William B Abrams Award from the [[Clinical Pharmacology & Therapeutics|American Society for Clinical Pharmacology & Therapeutics]] (1999). Bailey was the recipient of the Senior Investigator Award from the [[Canadian Society for Clinical Pharmacology]] (2005). Moreover, this research is now well known to the public through numerous articles in the lay press. Some were in the most influential and trusted publications including ''[[The New York Times]]'' (March 21, 2006), ''[[National Geographic]]'' (March 2007) and the ''[[Wall Street Journal]]'' (November 27, 2007). Thus, this research has received significant scientific, clinical and mainstream stature.

In later years, Bailey shifted the focus of his research slightly to assessing the effect of fruit juices on other potentially important mechanisms of drug absorption. Research found that grapefruit and other juices (orange and apple) inhibited a specific intestinal drug uptake transporter (organic anion transporting polypeptide 1A2; [[OATP1A2]]) to diminish oral drug absorption discernibly in humans. The initial publication in 2002, which has been cited more than 100 times, supported a new model of intestinal drug absorption and novel mechanism of food-drug interactions.<ref name=Bailey2002>{{Cite journal |doi=10.1046/j.1365-2125.1998.00764.x |pmid=9723817 |volume=46 |issue=2 |pages=101–110 |last1=Bailey |first1=David G. |last2=Malcolm |first2=J. |last3=Arnold |first3=O. |last4=David Spence |first4=J. |title=Grapefruit juice–drug interactions |journal=British Journal of Clinical Pharmacology |date=2002-01-04 |pmc=1873672 }}</ref> Bailey showed that the major [[flavonoid]] in grapefruit, [[naringin]], was an important clinically active inhibitor of intestinal OATP1A2. This appeared to be the first example of a single dietary constituent modulating drug transport in humans.

Bailey died in [[London, Ontario]] on August 27, 2022, at the age of 77.<ref>{{cite web |title=Dr. David George Bailey, PhD |url=https://www.westviewfuneralchapel.com/obituaries/dr-david-george-bailey-phd |website=Westview Funeral Chapel |access-date=2 September 2022 |archive-date=2 September 2022 |archive-url=https://web.archive.org/web/20220902141338/https://www.westviewfuneralchapel.com/obituaries/dr-david-george-bailey-phd/ |url-status=live }}</ref><ref>{{Cite news |last=Stewart |first=Monte |date=2022-09-23 |title=David Bailey, Olympian and pharmacologist who discovered the grapefruit effect, dead at age 77 |language=en-CA |work=The Globe and Mail |url=https://www.theglobeandmail.com/canada/article-david-bailey-olympian-and-pharmacologist-who-discovered-the-grapefruit/ |access-date=2022-09-23 |archive-date=2022-09-23 |archive-url=https://web.archive.org/web/20220923142529/https://www.theglobeandmail.com/canada/article-david-bailey-olympian-and-pharmacologist-who-discovered-the-grapefruit/ |url-status=live }}</ref><ref>{{Cite news |title=David Bailey, groundbreaking doctor and athlete, dies at 77 |url=https://lfpress.com/news/local-news/david-bailey-groundbreaking-doctor-and-athlete-dies-at-77 |first1=Norman |last1=De Bono |date=2022-09-05 |access-date=2022-09-23 |newspaper=London Free Press |language=en-CA |archive-date=2022-09-05 |archive-url=https://web.archive.org/web/20220905133453/https://lfpress.com/news/local-news/david-bailey-groundbreaking-doctor-and-athlete-dies-at-77 |url-status=live }}</ref>

==References==
{{Reflist}}

==External links==
*{{Cite web |title=Dr. David Bailey |url=https://www.uwo.ca/physpharm/ogirc/members/member-profiles/bailey.html |access-date=2022-09-23 |website=OGIRC }}
*{{Cite web |title=Dr. David Bailey finds new reason to avoid fruit juices when taking drugs |url=https://www.schulich.uwo.ca/schulichhome/articles/2008/08/20/dr-david-bailey-finds-new-reason-to-avoid-fruit-juices-when-taking-drugs.html |date=August 20, 2008|access-date=2022-09-23 |website=Schulich School of Medicine & Dentistry |language=en}}
* {{Team Canada|david-bailey}}
* {{Olympics.com|david-bailey}}
* {{Olympedia}}

{{authority control}}

{{DEFAULTSORT:Bailey, Dave}}
[[Category:1945 births]]
[[Category:2022 deaths]]
[[Category:Athletes (track and field) at the 1966 British Empire and Commonwealth Games]]
[[Category:Athletes (track and field) at the 1967 Pan American Games]]
[[Category:Athletes (track and field) at the 1968 Summer Olympics]]
[[Category:Canadian pharmacologists]]
[[Category:Canadian male middle-distance runners]]
[[Category:Olympic track and field athletes for Canada]]
[[Category:Track and field athletes from Toronto]]
[[Category:University of Toronto alumni]]
[[Category:Academic staff of the University of Western Ontario]]
[[Category:Commonwealth Games competitors for Canada]]
[[Category:Pan American Games bronze medalists for Canada]]
[[Category:Pan American Games bronze medalists in athletics (track and field)]]
[[Category:Universiade medalists in athletics (track and field)]]
[[Category:FISU World University Games silver medalists for Canada]]
[[Category:Medalists at the 1967 Summer Universiade]]
[[Category:Medalists at the 1967 Pan American Games]]
[[Category:20th-century Canadian sportsmen]]

David Bailey (pharmacologist) - Revision history

imported>Jevansen: Moving from Category:Pan American Games medalists in athletics (track and field) to Category:Pan American Games bronze medalists in athletics (track and field) using Cat-a-lot