http://debianws.lexgopc.com/wiki143/index.php?action=history&feed=atom&title=Craig_plot 2026-05-10T02:53:10Z Revision history for this page on the wiki MediaWiki 1.43.1 http://debianws.lexgopc.com/wiki143/index.php?title=Craig_plot&diff=3931347&oldid=prev 2024-01-23T09:35:45Z

<p><a href="/wiki143/index.php?title=Template:One_source" title="Template:One source">Template:One source</a></p> <p><b>New page</b></p><div>{{One source|date=January 2024}}<br /> [[File:craig-plot.png|thumb|Craig plot showing values of Hansch pi and Hammett sigma constants for 26 common organic substituents]]<br /> The &#039;&#039;&#039;Craig plot&#039;&#039;&#039;, named after Paul N. Craig, is a plot of two substituent parameters (e.g. [[Hansch-Fujita π constant]] and sigma constant) used in rational [[drug design]].&lt;ref&gt;{{Cite web |url=http://www.iupac.org/reports/1997/6905vandewaterbeemd/glossary.html |title=IUPAC glossary |access-date=2006-12-14 |archive-url=https://web.archive.org/web/20061209044630/http://www.iupac.org/reports/1997/6905vandewaterbeemd/glossary.html |archive-date=2006-12-09 |url-status=dead }}&lt;/ref&gt;<br /> <br /> Two most used forms of a Craig plot are<br /> * plotting the sigma constants of the [[Hammett equation]] versus [[hydrophobicity]]<br /> * plotting the steric terms of the [[Taft equation]] against [[hydrophobicity]]<br /> <br /> ==See also==<br /> * [[Quantitative structure-activity relationship]]<br /> * [[Acid dissociation constant|pKa]]<br /> <br /> ==References==<br /> {{Reflist}}<br /> <br /> ==Further reading==<br /> * {{cite journal|doi=10.1021/jm00290a004 | volume=14 | title=Interdependence between physical parameters and selection of substituent groups for correlation studies | journal=Journal of Medicinal Chemistry | pages=680–684 | last1 = Craig | first1 = Paul N.| year=1971 | issue=8 | pmid=5114063 }}<br /> <br /> [[Category:Medicinal chemistry]]<br /> <br /> <br /> {{medicinal-chem-stub}}</div>

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