imported>SimLibrarian at 05:30, 8 January 2024

2024-01-08T05:30:03Z

New page

{{Short description|Protein found in humans}}
{{Infobox_gene}}
'''Complement component 6''' is a [[protein]] that in humans is encoded by the ''C6'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: complement component 6 C6 complement C6 (Homo sapiens (human)) Gene ID: 729 |date= 24 November 2020| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=729| access-date = 9 December 2020 |website=www.ncbi.nlm.nih.gov }}</ref>

Complement component 6 is a protein involved in the [[complement system]]. It is part of the membrane attack complex which can insert into the cell membrane and cause the cell to [[Lysis|lyse]].

People with C6 deficiency are prone to bacterial infection.<ref name="entrez"/>

==References==
{{reflist}}

==Further reading==
{{refbegin | 2}}
*{{cite journal |vauthors=Davila S, Froeling FE, Tan A |title=New genetic associations detected in a host response study to hepatitis B vaccine. |journal=Genes Immun. |volume=11 |issue= 3 |pages= 232–8 |year= 2010 |pmid= 20237496 |doi= 10.1038/gene.2010.1 |display-authors=etal|doi-access=free }}
*{{cite journal |vauthors=Rajaraman P, Brenner AV, Butler MA |title=Common variation in genes related to innate immunity and risk of adult glioma. |journal=Cancer Epidemiol. Biomarkers Prev. |volume=18 |issue= 5 |pages= 1651–8 |year= 2009 |pmid= 19423540 |doi= 10.1158/1055-9965.EPI-08-1041 |pmc=2771723|display-authors=etal}}
*{{cite journal |vauthors=Cerhan JR, Novak AJ, Fredericksen ZS |title=Risk of non-Hodgkin lymphoma in association with germline variation in complement genes. |journal=Br. J. Haematol. |volume=145 |issue= 5 |pages= 614–23 |year= 2009 |pmid= 19344414 |doi= 10.1111/j.1365-2141.2009.07675.x |pmc=2820509|display-authors=etal}}
*{{cite journal |vauthors=Han S, Lan Q, Park AK |title=Polymorphisms in innate immunity genes and risk of childhood leukemia. |journal=Hum. Immunol. |volume=71 |issue= 7 |pages= 727–30 |year= 2010 |pmid= 20438785 |doi= 10.1016/j.humimm.2010.04.004 |pmc=2967770|display-authors=etal}}
*{{cite journal |vauthors=Liu T, Qian WJ, Gritsenko MA |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2005|pmid= 16335952 |doi= 10.1021/pr0502065 |pmc=1850943|display-authors=etal}}
*{{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 |pmc=1356129|display-authors=etal}}
*{{cite journal |vauthors=Talmud PJ, Drenos F, Shah S |title=Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. |journal=Am. J. Hum. Genet. |volume=85 |issue= 5 |pages= 628–42 |year= 2009 |pmid= 19913121 |doi= 10.1016/j.ajhg.2009.10.014 |pmc=2775832|display-authors=etal}}
*{{cite journal |author=Müller-Eberhard HJ |title=Molecular organization and function of the complement system. |journal=Annu. Rev. Biochem. |volume=57 |pages= 321–47 |year= 1988 |pmid= 3052276 |doi= 10.1146/annurev.bi.57.070188.001541 }}
*{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 |pmc=528928|display-authors=etal}}
*{{cite journal |vauthors=Eid NA, Hussein AA, Elzein AM |title=Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring. |journal=Malar. J. |volume=9 |pages= 119 |year= 2010 |pmid= 20459687 |doi= 10.1186/1475-2875-9-119 |pmc=2877684|display-authors=etal |doi-access=free }}
*{{cite journal |vauthors=Fosbrink M, Cudrici C, Tegla CA |title=Response gene to complement 32 is required for C5b-9 induced cell cycle activation in endothelial cells. |journal=Exp. Mol. Pathol. |volume=86 |issue= 2 |pages= 87–94 |year= 2009 |pmid= 19162005 |doi= 10.1016/j.yexmp.2008.12.005 |pmc=2699899|display-authors=etal}}
*{{cite journal |vauthors=Rajaraman P, Brenner AV, Neta G |title=Risk of meningioma and common variation in genes related to innate immunity. |journal=Cancer Epidemiol. Biomarkers Prev. |volume=19 |issue= 5 |pages= 1356–61 |year= 2010 |pmid= 20406964 |doi= 10.1158/1055-9965.EPI-09-1151 |pmc=3169167|display-authors=etal}}
*{{cite journal |vauthors=Ennis S, Jomary C, Mullins R |title=Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study. |journal=Lancet |volume=372 |issue= 9652 |pages= 1828–34 |year= 2008 |pmid= 18842294 |doi= 10.1016/S0140-6736(08)61348-3 |display-authors=etal|pmc=5983350 }}
*{{cite journal |vauthors=Soejima M, Tachida H, Tsuneoka M |title=Nucleotide sequence analyses of human complement 6 (C6) gene suggest balancing selection. |journal=Ann. Hum. Genet. |volume=69 |issue= Pt 3 |pages= 239–52 |year= 2005 |pmid= 15845028 |doi= 10.1046/j.1529-8817.2005.00165.x |display-authors=etal}}
*{{cite journal |vauthors=Bulla R, Bossi F, Agostinis C |title=Complement production by trophoblast cells at the feto-maternal interface. |journal=J. Reprod. Immunol. |volume=82 |issue= 2 |pages= 119–25 |year= 2009 |pmid= 19665237 |doi= 10.1016/j.jri.2009.06.124 |display-authors=etal}}
*{{cite journal |vauthors=Gancz D, Donin N, Fishelson Z |title=Involvement of the c-jun N-terminal kinases JNK1 and JNK2 in complement-mediated cell death. |journal=Mol. Immunol. |volume=47 |issue= 2–3 |pages= 310–7 |year= 2009 |pmid= 19864026 |doi= 10.1016/j.molimm.2009.09.016 |doi-access= free }}
*{{cite journal |vauthors=Parham KL, Roberts A, Thomas A |title=Prevalence of mutations leading to complete C6 deficiency (C6Q0) in the Western Cape, South Africa and detection of novel mutations leading to C6Q0 in an Irish family. |journal=Mol. Immunol. |volume=44 |issue= 10 |pages= 2756–60 |year= 2007 |pmid= 17257682 |doi= 10.1016/j.molimm.2006.11.022 |display-authors=etal}}
*{{cite journal |vauthors=Wu C, Ma MH, Brown KR |title=Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. |journal=Proteomics |volume=7 |issue= 11 |pages= 1775–85 |year= 2007 |pmid= 17474147 |doi= 10.1002/pmic.200601006 |s2cid=22474278 |display-authors=etal}}
*{{cite journal |vauthors=Bailey SD, Xie C, Do R |title=Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. |journal=Diabetes Care |volume=33 |issue= 10 |pages= 2250–3 |year= 2010 |pmid= 20628086 |doi= 10.2337/dc10-0452 |pmc=2945168|display-authors=etal}}
{{refend}}

==External links==
* {{MeshName|Complement+C6}}

{{Complement system}}

[[Category:Complement system]]

{{gene-5-stub}}

Complement component 6 - Revision history

imported>SimLibrarian at 05:30, 8 January 2024