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{{Infobox medical condition (new)
| name = Bromoderma
| synonyms = Bromoderma tuberosum
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| field = [[Dermatology]]
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'''Bromoderma''' is a skin condition characterized by an eruption of [[papule]]s and [[pustule]]s on the skin.<ref name="Andrews">{{cite book | vauthors = James WD, Berger T, Elston D |title=Andrews' Diseases of the Skin: Clinical Dermatology |date=2006 |publisher=Saunders Elsevier |location=Philadelphia |isbn=978-0-7216-2921-6 |edition=10th}}</ref>{{rp|135}} It is caused by hypersensitivity to [[bromide]]s, such as those found in certain drugs. There is at least one reported case of bromoderma caused by excessive consumption of a [[soft drink]] ([[Squirt_(soft_drink)|Ruby Red Squirt]]) containing [[brominated vegetable oil]].<ref>{{cite journal | vauthors = Jih DM, Khanna V, Somach SC | title = Bromoderma after excessive ingestion of Ruby Red Squirt | journal = The New England Journal of Medicine | volume = 348 | issue = 19 | pages = 1932–1934 | date = May 2003 | pmid = 12736294 | doi = 10.1056/NEJM200305083481921 | doi-access = free }}</ref>

== Signs and symptoms ==
The disease's symptoms can range from a mild [[Acneiform eruption|acneiform]] rash with [[Papule|papules]] and [[pustules]] to more severe conditions like [[panniculitis]], ulcers, and vegetative [[Nodule (medicine)|nodules]], also referred to as tuberous or vegetating bromoderma. Lesions usually affect the lower limbs, scalp, and face.<ref name="Nabatame Saito Sakuma Komaki 2010 pp. 283–288">{{cite journal | last1=Nabatame | first1=Shin | last2=Saito | first2=Yoshiaki | last3=Sakuma | first3=Hiroshi | last4=Komaki | first4=Hirofumi | last5=Nakagawa | first5=Eiji | last6=Sugai | first6=Kenji | last7=Sasaki | first7=Masayuki | last8=Uchiyama | first8=Kentaro | last9=Kosaka | first9=Maki | title=Bromoderma in a patient with migrating partial seizures in infancy | journal=Epilepsy Research | publisher=Elsevier BV | volume=91 | issue=2–3 | year=2010 | issn=0920-1211 | doi=10.1016/j.eplepsyres.2010.07.008 | pages=283–288| pmid=20674275 | s2cid=3408441 }}</ref><ref name="Anzai Fujiwara Inuzuka 2003 pp. 370–371">{{cite journal | last1=Anzai | first1=Saburo | last2=Fujiwara | first2=Sakuhei | last3=Inuzuka | first3=Miki | title=Bromoderma | journal=International Journal of Dermatology | publisher=Wiley | volume=42 | issue=5 | year=2003 | issn=0011-9059 | doi=10.1046/j.1365-4362.2003.01734.x | pages=370–371| pmid=12755974 | s2cid=221812784 }}</ref>

== Causes ==
One could characterize bromoderma as a kind of delayed [[Hypersensitivity|hypersensitivity reaction]], even though its pathogenesis is still unknown.<ref name="Maffeis Musolino Cambiaghi 2008 pp. 682–684">{{cite journal | last1=Maffeis | first1=Laura | last2=Musolino | first2=Maria Carmela | last3=Cambiaghi | first3=Stefano | title=Single-plaque vegetating bromoderma | journal=Journal of the American Academy of Dermatology | publisher=Elsevier BV | volume=58 | issue=4 | year=2008 | issn=0190-9622 | doi=10.1016/j.jaad.2007.08.011 | pages=682–684| pmid=18342716 }}</ref> Lesions can develop as soon as eight days after the medicine is first administered, but they typically do so after a prolonged period of use. High sebaceous gland concentrations on the skin are typically the site of lesions.<ref name="Hoefel Camozzato Hagemann Rhoden 2016 pp. 17–19">{{cite journal | last1=Hoefel | first1=Isadora da Rosa | last2=Camozzato | first2=Fernanda Oliveira | last3=Hagemann | first3=Laura Netto | last4=Rhoden | first4=Deise Louise Bohn | last5=Kiszewski | first5=Ana Elisa | title=Bromoderma in an infant | journal=Anais Brasileiros de Dermatologia | publisher=FapUNIFESP (SciELO) | volume=91 | issue=5 suppl 1 | year=2016 | issn=0365-0596 | doi=10.1590/abd1806-4841.20165013 | pages=17–19| pmid=28300882 | pmc=5324981 }}</ref>

== Diagnosis ==
Skin lesions, a patient's history of using [[bromide]], and the healing of lesions following drug withdrawal can all be used to make a diagnosis.<ref name="Bel Bartralot García Aparicio 2001 pp. 336–338">{{cite journal | last1=Bel | first1=Susana | last2=Bartralot | first2=Ramón | last3=García | first3=Daniel | last4=Aparicio | first4=Gloria | last5=Castells | first5=Antonio | title=Vegetant Bromoderma in an Infant | journal=Pediatric Dermatology | publisher=Wiley | volume=18 | issue=4 | year=2001 | issn=0736-8046 | doi=10.1046/j.1525-1470.2001.01954.x | pages=336–338| pmid=11576411 | s2cid=19631925 }}</ref>

== See also ==
* [[Skin lesion]]
* [[List of cutaneous conditions]]

== References ==
{{reflist}}

== Further reading ==
* {{cite journal | last1=Paloni | first1=Giulia | last2=Mattei | first2=Ilaria | last3=Ravagnan | first3=Enrico | last4=Cutrone | first4=Mario | title=Infantile Bromoderma | journal=The Journal of Pediatrics | publisher=Elsevier BV | volume=163 | issue=3 | year=2013 | issn=0022-3476 | doi=10.1016/j.jpeds.2013.03.071 | pages=920–920.e1 | pmid=23651770 | ref=none}}

== External links ==
{{Medical resources
| ICD11 = {{ICD11|ED81.Y}}
| ICD10 = {{ICD10|L27.1}}
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| ICD9 = {{ICD9|693.0}}
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| SNOMED CT = 8007005
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| Scholia = Q4973728
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{{Noninfectious inflammatory cutaneous conditions}}
{{Disorders of skin appendages}}

[[Category:Drug eruptions]]
[[Category:Bromine]]

Bromoderma - Revision history

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