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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
The human [[gene]] '''API5''' encodes the [[protein]] '''Apoptosis inhibitor 5'''.<ref name="pmid9307294">{{cite journal | vauthors = Tewari M, Yu M, Ross B, Dean C, Giordano A, Rubin R | title = AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal | journal = Cancer Research | volume = 57 | issue = 18 | pages = 4063–9 | date = September 1997 | pmid = 9307294 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: API5 apoptosis inhibitor 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8539}}</ref>

This gene encodes an [[apoptosis]] inhibitory protein whose expression prevents apoptosis after [[growth factor]] deprivation. This protein suppresses the [[transcription factor]] [[E2F1]]-induced apoptosis and also interacts with, and negatively regulates acinus, a [[Cell nucleus|nuclear]] factor involved in apoptotic [[DNA]] fragmentation. Its depletion enhances the [[Cytotoxicity|cytotoxic]] action of [[Chemotherapy|chemotherapeutic]] drugs. Crystal structure of API5 exhibited the function for protein-protein interaction <ref>{{cite journal | vauthors = Han BG, Kim KH, Lee SJ, Jeong KC, Cho JW, Noh KH, Kim TW, Kim SJ, Yoon HJ, Suh SW, Lee S, Lee BI | title = Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules | journal = The Journal of Biological Chemistry | volume = 287 | issue = 14 | pages = 10727–37 | date = March 2012 | pmid = 22334682 | doi = 10.1074/jbc.M111.317594 | pmc = 3322819 | doi-access = free }}</ref>

Diseases associated with API5 include colon [[adenocarcinoma]], and [[cervical cancer]].

API5 functions in nuclear export of mRNA.<ref>{{cite journal | vauthors = Bong SM, Bae SH, Song B, Gwak H, Yang SW, Kim S, Nam S, Rajalingam K, Oh SJ, Kim TW, Park S, Jang H, Lee BI | title = Regulation of mRNA Export Through API5 and Nuclear FGF2 Interaction. | journal = Nucleic Acids Res. | doi = 10.1093/nar/gkaa335 | pmid= 32383752 | year=2020| doi-access = free | volume = 48 | issue = 11 | pmc = 7293033 | pages = 6340–6352 }} </ref>

== References==
{{reflist}}

== Further reading ==
{{refbegin | 2}}
* {{cite journal | vauthors = Gianfrancesco F, Esposito T, Ciccodicola A, D'Esposito M, Mazzarella R, D'Urso M, Forabosco A | title = Molecular cloning and fine mapping of API5L1, a novel human gene strongly related to an antiapoptotic gene | journal = Cytogenetics and Cell Genetics | volume = 84 | issue = 3–4 | pages = 164–6 | year = 1999 | pmid = 10393420 | doi = 10.1159/000015247 | s2cid = 44601647 }}
* {{cite journal | vauthors = Kim JW, Cho HS, Kim JH, Hur SY, Kim TE, Lee JM, Kim IK, Namkoong SE | title = AAC-11 overexpression induces invasion and protects cervical cancer cells from apoptosis | journal = Laboratory Investigation; A Journal of Technical Methods and Pathology | volume = 80 | issue = 4 | pages = 587–94 | date = April 2000 | pmid = 10780674 | doi = 10.1038/labinvest.3780008 | doi-access = free }}
* {{cite journal | vauthors = Van den Berghe L, Laurell H, Huez I, Zanibellato C, Prats H, Bugler B | title = FIF [fibroblast growth factor-2 (FGF-2)-interacting-factor], a nuclear putatively antiapoptotic factor, interacts specifically with FGF-2 | journal = Molecular Endocrinology | volume = 14 | issue = 11 | pages = 1709–24 | date = November 2000 | pmid = 11075807 | doi = 10.1210/me.14.11.1709 | doi-access = free }}
* {{cite journal | vauthors = Sutherland HG, Mumford GK, Newton K, Ford LV, Farrall R, Dellaire G, Cáceres JF, Bickmore WA | title = Large-scale identification of mammalian proteins localized to nuclear sub-compartments | journal = Human Molecular Genetics | volume = 10 | issue = 18 | pages = 1995–2011 | date = September 2001 | pmid = 11555636 | doi = 10.1093/hmg/10.18.1995 | doi-access = free }}
* {{cite journal | vauthors = Li Z, Hu CY, Mo BQ, Xu JD, Zhao Y | title = [Effect of beta-carotene on gene expression of breast cancer cells] | journal = AI Zheng = Aizheng = Chinese Journal of Cancer | volume = 22 | issue = 4 | pages = 380–4 | date = April 2003 | pmid = 12703993 }}
* {{cite journal | vauthors = Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M | title = Nucleolar proteome dynamics | journal = Nature | volume = 433 | issue = 7021 | pages = 77–83 | date = January 2005 | pmid = 15635413 | doi = 10.1038/nature03207 | bibcode = 2005Natur.433...77A | s2cid = 4344740 }}
* {{cite journal | vauthors = Kim JE, Tannenbaum SR, White FM | title = Global phosphoproteome of HT-29 human colon adenocarcinoma cells | journal = Journal of Proteome Research | volume = 4 | issue = 4 | pages = 1339–46 | year = 2005 | pmid = 16083285 | doi = 10.1021/pr050048h }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = November 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 | s2cid = 7827573 | doi-access = free }}
* {{cite journal | vauthors = Morris EJ, Michaud WA, Ji JY, Moon NS, Rocco JW, Dyson NJ | title = Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo | journal = PLOS Genetics | volume = 2 | issue = 11 | pages = e196 | date = November 2006 | pmid = 17112319 | pmc = 1636698 | doi = 10.1371/journal.pgen.0020196 | doi-access = free }} {{open access}}
* {{cite journal | vauthors = Han BG, Kim KH, Lee SJ, Jeong KC, Cho JW, Noh KH, Kim TW, Kim SJ, Yoon HJ, Suh SW, Lee S, Lee BI | title = Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules | journal = J Biol Chem | volume = 287 | pages = 10727–37 | doi = 10.1074/jbc.M111.317594 | pmc = 3322819 | pmid=22334682 | year=2012| issue = 14 | doi-access = free }}
* {{cite journal | vauthors = Bong SM, Bae SH, Song B, Gwak H, Yang SW, Kim S, Nam S, Rajalingam K, Oh SJ, Kim TW, Park S, Jang H, Lee BI | title = Regulation of mRNA Export Through API5 and Nuclear FGF2 Interaction. | journal = Nucleic Acids Res. | doi = 10.1093/nar/gkaa335 | pmid= 32383752 | year=2020| doi-access = free | volume = 48 | issue = 11 | pmc = 7293033 | pages = 6340–6352 }}
{{refend}}

API5 - Revision history

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