View source for VE (nerve agent)

{{chembox
| Watchedfields = changed
| verifiedrevid = 470627364
|   Name = VE
|   ImageFile = VE-2D-skeletal.png
|   ImageName = Skeletal formula of VE
| ImageClass = skin-invert-image
|   ImageFile1 = VE-3D-balls.png
|   ImageName1 = Ball-and-stick model of VE
| ImageClass1 = bg-transparent
|   IUPACName = (''S'')-(ethyl {[2-(diethylamino)ethyl]sulfanyl}(ethyl)phosphinate)
| Section1 = {{Chembox Identifiers
|   ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 59011
| PubChem = 65568
| InChI = 1/C10H24NO2PS/c1-5-11(6-2)9-10-15-14(12,8-4)13-7-3/h5-10H2,1-4H3
| InChIKey = QXRUNSUMQBTCQS-UHFFFAOYAY
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C10H24NO2PS/c1-5-11(6-2)9-10-15-14(12,8-4)13-7-3/h5-10H2,1-4H3
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = QXRUNSUMQBTCQS-UHFFFAOYSA-N
| CASNo = 21738-25-0
|   SMILES = O=P(OCC)(SCCN(CC)CC)CC
}}
| Section2 = {{Chembox Properties
|   C = 10 | H = 24 | N = 1 | O = 2 | P = 1 | S = 1
|   Density =
|   MeltingPt =
|   BoilingPt =
  }}
}}

'''VE''' ('''''S''-(diethylamino)ethyl ''O''-ethyl ethylphosphonothioate''') is a "V-series" [[nerve agent]] closely related to the better-known [[VX (nerve agent)|VX nerve agent]].  It was first reported in 1958 as a pesticide.<ref>{{cite patent | country = GB | number = 797603 | title = New basic esters of thiophosphonic acids and salts thereof | inventor = Ghosh Ranajit | url = https://worldwide.espacenet.com/patent/search/family/010118394/publication/GB797603A?q=GB797603 }}</ref>

Like most of the agents in the V-series (with the exception of VX), VE has not been extensively studied outside of [[military science]].{{cn|date=February 2023}}

It is commonly theorized that the so-called "second-generation" V series agents came from a [[Cold War]] era [[Russia]]n chemical weapons development program.{{cn|date=February 2023}} They may have been developed sometime between 1950 and 1990. They have similar lethal dose levels to VX (between 10–50&nbsp;mg) and have similar symptoms and method of action to other nerve agents that act on [[cholinesterase]], and treatment remains the same, but the window for effectively treating second generation V series [[seizure]]s is shorter.{{cn|date=February 2023}} In addition to the standard seizures, some of the second generation V series agents are known to cause [[coma]]s.

==References==
{{Reflist}}

{{Chemical warfare}}
{{Acetylcholine metabolism and transport modulators}}

[[Category:Acetylcholinesterase inhibitors]]
[[Category:Diethylamino compounds]]
[[Category:V-series nerve agents]]
[[Category:Phosphonothioates]]
[[Category:Ethyl esters]]