View source for Talk:Plasmodium

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== Evolution & Mechanism of Mosquito Infection and Transmission ==

Although the Evolution section of this article mentions how ''Plasmodium'' has evolved to infect the human liver and eventually red blood cells, it does not mention the evolutionary aspects and mechanism(s) that ''Plasmodium'' utilize to infect mosquitoes. [[User:Murtha.22]] ([[User talk:Murtha.22]])

:: Ok, so why not find some good sources on these aspects and extend the section with suitable references? [[User:Chiswick Chap|Chiswick Chap]] ([[User talk:Chiswick Chap|talk]]) 20:02, 30 September 2014 (UTC)

::Sounds good, thanks for the feedback. I will look into this. --[[User:Murtha.22|Murtha.22]] ([[User talk:Murtha.22|talk]]) 04:08, 15 October 2014 (UTC)

== Evolution - Mosquito Transmission ==

*The Evolution section of this article states that ''Plasmodium'' "survive and infect" mosquitoes. This may seem to imply that ''Plasmdodium'' decreases the fitness of mosquitoes. However, the mosquitoes that transmit ''Plasmdodium'' do not have a decreased fitness. This result indicates that vector fitness is an important selective agent shaping the evolution of ''Plasmodium''. I have added a sentence and citation to the article.  <small><span class="autosigned">—&nbsp;Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[User:Murtha.22|Murtha.22]] ([[User talk:Murtha.22|talk]] • [[Special:Contributions/Murtha.22|contribs]]) 03:10, 1 October 2014 (UTC)</span></small><!-- Template:Unsigned --> <!--Autosigned by SineBot-->


== couple suggestions to add to the article ==

* I would like to see more info on the influence of Plasmodium on the human genome. We know that humans and plasmodium have been evolving together for quite a while so, what are the resistance made by he human body to stand the illness? Some research have lead to the increase in Sickle gene in population where malaria is still endemic.
* Another suggestion is to improve the history behind the evolution of the parasite as of: how and when each type of Plasmodium ruled out many human lives.
* A last suggestion is to talk about the multiple attempts and weapons used to eradicate the disease ( malaria) caused by Plasmodium in humans; such as DDT and their effects.  <small><span class="autosigned">—&nbsp;Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[User:Daouda.1|Daouda.1]] ([[User talk:Daouda.1|talk]] • [[Special:Contributions/Daouda.1|contribs]]) 03:37, 1 October 2014 (UTC)</span></small><!-- Template:Unsigned --> <!--Autosigned by SineBot-->

:: The first and third suggestions concern two other topics, [[Malaria]] and [[History of malaria]], and would be best dealt with in those places (if not already covered), not in this article. The suggestion about the evolutionary history of the parasite is relevant but will require careful review of the peer-reviewed literature. Please make sure any additions are properly cited with full inline references as if you were writing a formal review paper. [[User:Chiswick Chap|Chiswick Chap]] ([[User talk:Chiswick Chap|talk]]) 06:12, 15 October 2014 (UTC)

== Time for a rewrite? ==

Hi all! I'm currently going through and re-organizing/re-writing chunks of this article. Large chunks of this seem to be written in dense jargon, and some fairly controversial statements on taxonomy sit unreferenced. I'll try to separate my edits by topic so that if you see me doing something stupid you can easily revert the relevant edits and let me know and we can all chat here! Any thoughts, suggestions, or help are very welcome! [[User:Ajpolino|Ajpolino]] ([[User talk:Ajpolino|talk]]) 04:27, 1 June 2016 (UTC)
:I've removed the following text from the Life Cycle section:
{{quote|The development from the hepatic stages to the erythrocytic stages  has been obscure. In 2006<ref name="Sturm2006">{{cite journal  |vauthors=Sturm A, Amino R, van de Sand C, etal |title=Manipulation of host hepatocytes by the malaria parasite for delivery into liver sinusoids |journal=Science |volume=313 |issue=5791 |pages=1287–90 |date=September 2006 |pmid=16888102 |doi=10.1126/science.1129720 |url=http://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=16888102}}</ref> it was shown that the parasite buds off the hepatocytes in merosomes containing hundreds or thousands of merozoites. These merosomes have been subsequently shown<ref name="Baer2007">{{cite journal |author=Baer K, Klotz C, Kappe SH, Schnieder T, Frevert U |title=Release of hepatic ''Plasmodium yoelii'' merozoites into the pulmonary microvasculature |journal=PLoS Pathog. |volume=3 |issue=11 |pages=e171 |date=November 2007 |pmid=17997605 |pmc=2065874 |doi=10.1371/journal.ppat.0030171 |url=http://dx.plos.org/10.1371/journal.ppat.0030171}}</ref> to lodge in the pulmonary capillaries and to disintegrate there slowly over 48–72 hours releasing merozoites. Erythrocyte invasion is enhanced when blood flow is slow and the cells are tightly packed: both of these conditions are found in the alveolar capillaries.}}
:While it is referenced, the two references are primary sources. The two papers were done in rodent-infecting strains (''P. berghei'' in 2006 and ''P. yoelii'' in 2007) and there's no indication (that I know of) that these mechanisms are conserved across all ''Plasmodium'' species. Perhaps this kind of thing would be more appropriate at those specific articles. But really, it'd probably be best if we find a review covering this kind of thing. It definitely seems too specific for a section on the life cycle of the genus ''Plasmodium''... Happy to talk about it if anyone objects... [[User:Ajpolino|Ajpolino]] ([[User talk:Ajpolino|talk]]) 04:45, 1 June 2016 (UTC)
Ok! I tried to trim the tables out of the article that fit better at the list articles ([[Plasmodium species infecting birds]], [[Plasmodium species infecting reptiles]], etc.). This way we won't have to maintain tables at both locations and the tables can still be easily found (they're linked to at each subsection of this article). If anyone has concerns about this, let's talk about it here. [[User:Ajpolino|Ajpolino]] ([[User talk:Ajpolino|talk]]) 22:55, 10 July 2016 (UTC)
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== Genome? ==

A few words about the genome would be appropriate. Number of genes? Regards, ... [[User:PeterEasthope|PeterEasthope]] ([[User talk:PeterEasthope|talk]]) 15:01, 8 October 2021 (UTC)
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