View source for Talk:Norepinephrine

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== Many apologies ==
I have had many family issues and I profusely apologize in the delay of this review. I will jump in again. I'll be finishing the review up with my other account. Best Regards, [[User:Barbara (WVS)|Barbara (WVS)]] ([[User talk:Barbara (WVS)|talk]]) 15:40, 22 January 2016 (UTC) otherwise known as {{U|Bfpage}}
:I've been mostly out of action for the last couple of weeks, so I'm actually happy that not much has happened here during that time.  I do look forward to getting this in motion, though.  Best regards, [[User:Looie496|Looie496]] ([[User talk:Looie496|talk]]) 16:34, 22 January 2016 (UTC)
::I do feel badly because the other reviews that I have done have been completed in a week or less. I'm back to work. Best Regards, [[User:Barbara (WVS)|Barbara (WVS)]] ([[User talk:Barbara (WVS)|talk]]) 23:46, 23 January 2016 (UTC)

== splitting biosyntheses ==
{{Archive top|result= This RfC was closed because a clear consensus was reached to not split the paragraph into a seperate article. <span style="background:#fff0cc;font-size:17px" font-family:=   "Monotype">[[User:ARUNEEK|<span style=   "color:green">Aru@''baska''</span>]]<sup>[[User   talk:ARUNEEK|<span style=   "color:#FC0;letter-spacing:-2px">❯❯❯</span>   Vanguard]]</sup></span> 08:09, 25 November 2016 (UTC)  }}
various compounds have their biosynthesis section oversized. they can be split into their pages and referenced. example: norepinephrine is synthesized from dopamine, which is synthesized from tyrosine. only the dopamine to norepinephrine part can be left in the page, contrary to the current overdetail starting from tyrosine[[User:Minimobiler|Minimobiler]] ([[User talk:Minimobiler|talk]]) 03:31, 1 November 2016 (UTC)

: This is your opinion. The article was also passed as a good article - you need to propose the change in material not just go ahead and mention this afterwards.--[[User:Iztwoz|Iztwoz]] ([[User talk:Iztwoz|talk]]) 06:43, 1 November 2016 (UTC)
{{reply|Iztwoz}} the talk page post was made before the edit, check time. now, the articles are bloated. call others of wiki project medicine.[[User:Minimobiler|Minimobiler]] ([[User talk:Minimobiler|talk]]) 06:58, 1 November 2016 (UTC)
::{{reply|Minimobiler}} regardless - the entry on the talk page needs to be a proposal left for comments from others.--[[User:Iztwoz|Iztwoz]] ([[User talk:Iztwoz|talk]]) 07:27, 1 November 2016 (UTC)
{{reply|Iztwoz}} bring the others.[[User:Minimobiler|Minimobiler]] ([[User talk:Minimobiler|talk]]) 08:32, 1 November 2016 (UTC)
*'''Oppose''' the biosynthesis section you mention is only a small part of this article - about 4-5 paragraphs. It seems needless to split each paragraph to a new page. An interested reader can click on the wikilinks to view each page (eg dopamine, tyrosine) to view more information about how they are synthesised. --[[User:LT910001|Tom (LT)]] ([[User talk:LT910001|talk]]) 21:56, 4 November 2016 (UTC)
*'''Oppose''' - the biosynthesis of an arbitrary neurotransmitter from an associated basic dietary constituent (e.g., amino acids) is a fairly important subtopic that should be covered in any neurotransmitter article.  Norepinephrine is derived from dopamine which can be derived from other dietary components or obtained in the diet; however, dopamine can't cross the blood-brain barrier, so dietary dopamine can't function as a neurotransmitter or be metabolized into norepinephrine in the CNS; consequently, almost all of the norepinephrine that is produced in the brain is derived from dietary constituents that are metabolized into dopamine and then norepinephrine.<br />FWIW, norepinephrine can also be synthesized in humans from [[Octopamine_(neurotransmitter)|para-octopamine]] by [[CYP2D6]] ({{PMID|24374199}}), but that's not a significant biosynthetic pathway. [[User:Seppi333|'''<span style="color:#32CD32;">Seppi</span>''<span style="color:Black;">333</span>''''']]&nbsp;([[User Talk:Seppi333|Insert&nbsp;'''2¢''']]) 23:16, 4 November 2016 (UTC)
*I don't have much of an opinion about whether the section should be shortened.  I would however prefer for it to be located further down in the page -- it is probably too complex for most readers and is likely to make some stop reading when they encounter it. [[User:Looie496|Looie496]] ([[User talk:Looie496|talk]]) 14:38, 5 November 2016 (UTC)
*'''Oppose''' - It is useful to see how the biosynthesis of norepinephrine relates to the biosynthesis of other neurotransmitters in the same biosynthetic pathway.  At the same time, I think the size of the figure could be considerably reduced without loss of readability. [[User:Boghog|Boghog]] ([[User talk:Boghog|talk]]) 19:29, 5 November 2016 (UTC)
*'''Oppose''' - If someone wants to know "how does the body make norepinephrine?", the logical place to start is from the amino acid source. The diagram should be re-drawn as an SVG, though. I'll put that on my to-do list. --[[User:Slashme|Slashme]] ([[User talk:Slashme|talk]]) 08:07, 8 November 2016 (UTC)
*'''Oppose''' - As it stands the idea of shortening the article is inappropriate. The subject simply happens to be complex and we could be doing nobody any favours if we tried to simplify it by evisceration. The run-of-the-mill reader is not likely to read much of this article anyway, so a bit of extra complexity is not really prohibitive. It would be perfectly possible to improve matters by expanding the content and restructuring the topic into separate articles coherently linked, but you won't manage that by by snipping out arbitrary chunks of material; it would require a serious design effort. [[User:JonRichfield|JonRichfield]] ([[User talk:JonRichfield|talk]]) 07:09, 9 November 2016 (UTC)
*'''Oppose'''. The "biosynthesis" section is proportionate to the rest of the article. [[User:Maproom|Maproom]] ([[User talk:Maproom|talk]]) 09:11, 20 November 2016 (UTC)
*'''Oppose''' My opinion: The biosynthesis section is important to the article, is only 4 paragraphs, several hundred words. and not worth splitting into separate articles.  Comment write the RFC with a specific question of the text to be changed, before and after. [[User:CuriousMind01|CuriousMind01]] ([[User talk:CuriousMind01|talk]]) 13:47, 20 November 2016 (UTC)
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== Heart rate. ==

Nor adrenaline actually decreases heart rate.
reference from Principles of general pharmacology by KD Tripathi. [[User:Zaidanzargar|Zaidanzargar]] ([[User talk:Zaidanzargar|talk]]) 07:27, 22 May 2020 (UTC)

:References to this on the page would need to be adjusted and refs supplied.--[[User:Iztwoz|Iztwoz]] ([[User talk:Iztwoz|talk]]) 09:21, 22 May 2020 (UTC)

== noradrenaline  ==

what is noradrenaline [[Special:Contributions/105.245.173.41|105.245.173.41]] ([[User talk:105.245.173.41|talk]]) 05:55, 9 September 2024 (UTC)

:those who know💀💀💀 [[Special:Contributions/176.64.23.114|176.64.23.114]] ([[User talk:176.64.23.114|talk]]) 15:31, 3 October 2024 (UTC)

== Graphic representation of norepinephrine pathways seems unnecessarily complex ==

I find the graphic used in the article (sub-section "biosynthesis"),titled "Biosynthetic pathways for catecholamines and trace amines in the human brain" unnecessarily complex for this overview article. 
It is certainly important information, but it is almost frightening to look at and will most certainly not  inform the standard reader (even the curious one) about the relevant biochemical pathways. 
The graphic should include the classic steps from L-Phenylalanine to L-Tyrosine to L-DOPA to Dopamine and then norepinephrine (including the relevant enzymes). 
Pathways, that are essentially just branching off from this, should be dealt with in a separate article for specialists. [[User:Aurelien101|Aurelien101]] ([[User talk:Aurelien101|talk]]) 17:41, 2 January 2025 (UTC)