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{{merged-from|Cholemia|30 September 2023}}

==Wiki Education Foundation-supported course assignment==
[[File:Sciences humaines.svg|40px]] This article was the subject of a Wiki Education Foundation-supported course assignment, between <span class="mw-formatted-date" title="2020-05-11">11 May 2020</span> and <span class="mw-formatted-date" title="2020-06-05">5 June 2020</span>. Further details are available [[Wikipedia:Wiki_Ed/University_of_Michigan_Medical_School/Med_Communications_Wikipedia_May_2020_UMMS_M3_(Spring)|on the course page]]. Student editor(s): [[User:Taglel|Taglel]].

{{small|Above undated message substituted from [[Template:Dashboard.wikiedu.org assignment]] by [[User:PrimeBOT|PrimeBOT]] ([[User talk:PrimeBOT|talk]]) 01:08, 17 January 2022 (UTC)}}
== Modifying Organization ==
Hi! I am a new wiki editor and would love to get advice from more experienced editors. I felt like this article is really hard to understand due to a general lack of logical flow, poor organization, excess medical jargon, superfluous/repetitive information. Thus, I would love to know your thoughts on some changes I plan to make on this article. 

Firstly, I would like to improve the flow and organization as follows: Definition (including summary of article), Etiology (including risk factors, triggers, genetics, virology, etc.), Pathophysiology, Clinical Signs & Symptoms, Diagnostics (subheadings: imaging, labs), Treatment, Prevention, Prognosis, Complications, Epidemiology (Incidence, prevalence, etc.), Special Populations (Neonates), Historical Significance (early discoveries, historical figures, etc.), References.

Secondly, I would like to add more current literature/references. 

I plan to work on this article for the next few weeks, so it will definitely be a work in progress. Thanks in advance for your input.[[User:Taglel|Taglel]] ([[User talk:Taglel|talk]]) 19:18, 15 May 2020 (UTC)

== This article ==

Does not explain very well what the actual cause of jaundice is. It starts trailing off like my biology teacher and doesn't conclude or simplify the information. I went to another website and I understand instantly the cause of jaundice. IMPROOOOVEE!!! Also, under symptoms it doesn't actually give a symptom. It just rambles on about jaundice eye's in poetry. <span style="font-size: smaller;" class="autosigned">—Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/86.13.65.217|86.13.65.217]] ([[User talk:86.13.65.217|talk]]) 17:42, 1 December 2009 (UTC)</span><!-- Template:UnsignedIP --> <!--Autosigned by SineBot-->

== Jaundice ==
Is there any information available on jaundice treatment? [[User:68.55.216.197|68.55.216.197]] 02:14, 13 February 2007 (UTC)


I wonder if the article should explain what happens if jaundice is  not treated.  Is a baby's life in danger if it is not treated for jaundice (assuming the jaundice does not go away by itself)?
Saleem ready discussed: ''"With high doses of bilirubin (severe hyperbilirubinemia) there can be a complication known as [[kernicterus]]. This is the chief reason for neonatal jaundice to be treated. The effects of kernicterus range from fever, seizures, and a high-pitched crying to mental retardation."'' [[User:Davidruben|David Ruben]] <sup> [[User talk:Davidruben|Talk]] </sup> 00:57, 1 March 2006 (UTC)

::That section appears to have disappeared.  Could we have it back? --[[User:Puellanivis|Puellanivis]] 22:01, 2 October 2006 (UTC)

:::I believe it moved to [[Neonatal jaundice]], no?--[[User:Stevenfruitsmaak|Steven Fruitsmaak]] <small>([[User_talk:Stevenfruitsmaak|Reply]])</small> 12:22, 3 October 2006 (UTC)

Who is the idiot that keeps changing Pre-hepatic urine color to light? Lets do an experiement. Go to Africa, get malaria, and go to the bathroom and tell me if your urine is light. It's not. Any hemolytic anemia is going to increase your unconjugated bilirubin and your liver will conjugate the bilirubin to increase the conjugated bilirubin which will go into your intestines, be broken down by bacteria to urobilinogen and oxidized to urobilin and then reabsorbed and put into the urine. If you have more, you will reabsorb more and your urine will be darker. I even put a reference. You guys at wiki. Sometimes.  <small><span class="autosigned">—Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[User:Mastac741|Mastac741]] ([[User talk:Mastac741|talk]] • [[Special:Contributions/Mastac741|contribs]]) 15:37, 5 April 2009 (UTC)</span></small><!-- Template:Unsigned --> <!--Autosigned by SineBot-->

==Popular reference==
The pop culture reference was not helpful. I removed it to give the aritcle a boost of credibililty.<small><span class="autosigned">—Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[User:24.62.130.213|24.62.130.213]] ([[User talk:24.62.130.213|talk]] • [[Special:Contributions/24.62.130.213|contribs]]) 05:44, 17 April 2006</span></small><!-- Template:Unsigned -->

There really should be the symptoms and treatments available.[[User:82.128.11.179|82.128.11.179]] 16:16, 1 February 2007 (UTC) Tolulope Ogunbiyi


The article is referenced to a "dictionary of cliches." That can't be right!![[User:70.116.136.85|70.116.136.85]] 22:57, 18 March 2007 (UTC)

==Bryanton's Triangle==

"Patients often complain of severe itching or "pruritus". Often, only Bryanton's triangle will remain unscratched. Bryanton's triangle is a single triangle of skin on the patient's back that the patient is unable to reach, and therefore scratch. It varies in size depending on the flexibility of the patient, and occasionally presents as a diamond in lower BMI patients."

I looked this up on Google, and while it appears that there is no such thing as a "Bryanton's Triangle" there is something called "Bryant's Triangle" which isn't located anywhere on the back.  Although the description they give sounds reasonable, whatever it is, it is not "Bryanton's Triangle". [[Special:Contributions/75.120.169.120|75.120.169.120]] ([[User talk:75.120.169.120|talk]]) 18:38, 24 November 2007 (UTC)

what is hepatitis A,B and C? --[[Special:Contributions/202.164.149.30|202.164.149.30]] ([[User talk:202.164.149.30|talk]]) 06:44, 21 December 2007 (UTC)
: If only there were such a thing as an instantly searchable online encyclopaedia, eh? [[Special:Contributions/87.114.25.228|87.114.25.228]] ([[User talk:87.114.25.228|talk]]) 14:31, 9 March 2008 (UTC)


Include information on how hyperbilirubinemia causes intrinsic staining of the teeth  <small>—Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/209.6.224.2|209.6.224.2]] ([[User talk:209.6.224.2|talk]]) 20:25, 8 January 2008 (UTC)</small><!-- Template:UnsignedIP --> <!--Autosigned by SineBot-->

== Lab tests ==

The table is good, but do you think we should add other tests in to determine if it is pre/intra or post hepatic? For example alkaline phosphatase raised in post hepatic, and Gamma glutamyl transpeptidase raised in intra hepatic. Or break down products of bilirubin, for example urobilinogen being decreased in the urine of patients with posthepatic jaundice.[[Special:Contributions/82.10.78.130|82.10.78.130]] ([[User talk:82.10.78.130|talk]]) 09:04, 13 May 2008 (UTC)


Is there such a thing as urobilirubin  - is it supposed to be urobilin (see hepatic jaundice) I searched guyton 11th ed 2005 couldn't find that word anywhere  <small>—Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/59.167.100.198|59.167.100.198]] ([[User talk:59.167.100.198|talk]]) 09:17, 29 May 2008 (UTC)</small><!-- Template:UnsignedIP --> <!--Autosigned by SineBot-->

That's because they changed the name. A lot happens in medicine in a few years. Urobilinogen is formerly known as Stercobilinogen. I bet that's the term they use in your old textbook.  <small><span class="autosigned">—Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[User:Mastac741|Mastac741]] ([[User talk:Mastac741|talk]] • [[Special:Contributions/Mastac741|contribs]]) 20:12, 7 April 2009 (UTC)</span></small><!-- Template:Unsigned --> <!--Autosigned by SineBot-->

When urobilinogen is oxydized it becomes urobilin.  <span style="font-size: smaller;" class="autosigned">—Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/83.7.204.33|83.7.204.33]] ([[User talk:83.7.204.33|talk]]) 10:46, 7 September 2010 (UTC)</span><!-- Template:UnsignedIP --> <!--Autosigned by SineBot-->

== Picture ==

Jaundice can also cause pixelation of the eyelids--[[User:TheBladeRoden|TheBladeRoden]] ([[User talk:TheBladeRoden|talk]]) 19:01, 4 August 2010 (UTC)

:Wikipedia is not censored and we have lots of scary pictures, but this one is unintentionally terrifying. [[Special:Contributions/80.221.34.183|80.221.34.183]] ([[User talk:80.221.34.183|talk]]) 20:18, 11 August 2010 (UTC)

Yeah...I would kinda like a text only version of this page...yuck...  <span style="font-size: smaller;" class="autosigned">—Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/99.29.195.191|99.29.195.191]] ([[User talk:99.29.195.191|talk]]) 01:11, 20 September 2010 (UTC)</span><!-- Template:UnsignedIP --> <!--Autosigned by SineBot-->

-------------------------

The article says this:

"It was once believed persons suffering from the medical condition jaundice saw everything as yellow."

However, it neglects to tell us whether or not this is true.

[[User:Rosa Lichtenstein|Rosa Lichtenstein]] ([[User talk:Rosa Lichtenstein|talk]]) 17:08, 17 October 2010 (UTC)

-------------------------

You know, if the pictures are scary you can right-click, click on block content, and click on the picture you don't want to see. When you do this it will not show them. You can unblock them, as well.

[[User:Hiediarobalx]] 05:38 27 September 2012 (UTC)

-------------------------

In this picture https://en.wikipedia.org/wiki/Jaundice#/media/File:Jaundice08.jpg the pillow appears to also suffer from Jaundice.
In other words -- the picture has been yellowed, it has been enhanced and inforced. Is this symptomatic to WP in general?  <!-- Template:Unsigned IP --><small class="autosigned">—&nbsp;Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/2001:980:42B2:1:105F:1852:6D10:3E30|2001:980:42B2:1:105F:1852:6D10:3E30]] ([[User talk:2001:980:42B2:1:105F:1852:6D10:3E30#top|talk]]) 18:01, 5 January 2020 (UTC)</small> <!--Autosigned by SineBot-->

==Invitation to edit==
It is proposed that [[Jaundice]] be part of the trial of a new template; see the green strip at the top of [[Pain]] where it has been in place for a couple of months. The purpose of this project is to encourage readers to edit, while equipping them with the basic tools. If you perceive a problem with this, or have any suggestions for improvement, please discuss at the project [[Wikipedia talk:ITE|talk page]]. --[[User:Anthonyhcole|Anthonyhcole]] ([[User talk:Anthonyhcole|talk]]) 10:07, 10 January 2011 (UTC)

== Is this picture appropriate? ==
http://commons.wikimedia.org/wiki/File%3AJaundice08.jpg

I know Wikipedia is not censored, but at the same time, its not uncommon in many medical textbook images for the facial features of a patient to be hidden/blurred for privacy reasons. In this case, the patient's entire face is shown - Should we at least aim to avoid revealing the patient's identity, even if this picture does a good job in showing the actual condition in a hospital setting? Would covering up the patient's eyes impair the reader's understanding of the appearance of jaundice?
-[[User:A1candidate|A1candidate]] ([[User talk:A1candidate|talk]]) 11:24, 28 February 2013 (UTC)

[August 30, 2013] I agree. The pictures used on this article are not appropriate, and I believe may violate copyright law.  <span style="font-size: smaller;" class="autosigned">— Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/24.141.55.198|24.141.55.198]] ([[User talk:24.141.55.198|talk]]) 03:19, 31 August 2013 (UTC)</span><!-- Template:Unsigned IP --> <!--Autosigned by SineBot-->

[August 30, 2013: Part 2] Due to a lack of evidence showing the patients agreed to have their pictures posted online, they have been removed from the Wiki article.  <span style="font-size: smaller;" class="autosigned">— Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/24.141.55.198|24.141.55.198]] ([[User talk:24.141.55.198|talk]]) 03:23, 31 August 2013 (UTC)</span><!-- Template:Unsigned IP --> <!--Autosigned by SineBot-->
::Patient has given consent for release under a CC BY SA license. Maybe you could try asking the uploader next time. [[User:Jmh649|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Jmh649|talk]] · [[Special:Contributions/Jmh649|contribs]] · [[Special:EmailUser/Jmh649|email]]) (if I write on your page reply on mine) 05:45, 31 August 2013 (UTC)
::Please provide a link. Maybe you could try being less passive aggressive next time. Thanks.  <span style="font-size: smaller;" class="autosigned">— Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/24.141.55.198|24.141.55.198]] ([[User talk:24.141.55.198|talk]]) 03:29, 2 September 2013 (UTC)</span><!-- Template:Unsigned IP --> <!--Autosigned by SineBot-->
:::A link to what? [[User:Jmh649|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Jmh649|talk]] · [[Special:Contributions/Jmh649|contribs]] · [[Special:EmailUser/Jmh649|email]]) (if I write on your page reply on mine) 08:35, 2 September 2013 (UTC)

VERY heteronormative, just putting it out there  <small class="autosigned">—&nbsp;Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/144.173.149.117|144.173.149.117]] ([[User talk:144.173.149.117|talk]]) 10:37, 12 May 2016 (UTC)</small><!-- Template:Unsigned IP --> <!--Autosigned by SineBot-->

== Where should we mention cholestatic jaundice ==

Other articles refer to [[cholestatic jaundice]] but it's not mentioned here. - [[User:Rod57|Rod57]] ([[User talk:Rod57|talk]]) 05:43, 11 June 2013 (UTC)
: Thank you, I have redirected to [[obstructive jaundice]]. [[User:LT910001|LT90001]] ([[User talk:LT910001|talk]]) 09:45, 2 September 2013 (UTC)

== The Simpsons? ==

Should we include something about The Simpsons on here?

==Whites of the eyes==
Are the sclera. And yes jaundice makes them often appear yellow. [[User:Doc James|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Doc James|talk]] · [[Special:Contributions/Doc James|contribs]] · [[Special:EmailUser/Doc James|email]]) 20:20, 3 May 2017 (UTC)

==[[WP:LEAD]]==
Lead is supposed to be a summary of the condition in question. [[User:Doc James|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Doc James|talk]] · [[Special:Contributions/Doc James|contribs]] · [[Special:EmailUser/Doc James|email]]) 11:08, 26 May 2020 (UTC)

== Epidemiology Section ==

I noticed there is almost no content in the epidemiology section. This may be a great section where we can add data regarding jaundice in different ages, ethnicities, as well as genetic factors contributing to development of jaundice-associated diseases. I appreciate your thoughts, comments, and ideas.[[User:Taglel|Taglel]] ([[User talk:Taglel|talk]]) 13:43, 27 May 2020 (UTC)
::On Wikipedia we generally use "epidemiology" to mean incidence and prevalence. If we have data on this for different ages and ethnicities sure. 
::With respect to genetics are you referring to the pathophysiology of the condition? Or are you referring to some generic causes of the condition such as [[Crigler–Najjar syndrome]] which is discussed in the diagnosis section. [[User:Doc James|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Doc James|talk]] · [[Special:Contributions/Doc James|contribs]] · [[Special:EmailUser/Doc James|email]]) 05:52, 29 May 2020 (UTC)

Wonderful! I will add in some references regarding epidemiology. 

I think generally, I wanted to add a sub-section on risk factors for developing jaundice including genetic and environmental. Regarding genetics, I wanted to add genetic mutations that have been shown to been major risk factors for chronic liver disease progression (both ALD and NAFLD) (i.e. I148M in PNPLA3 gene). Environmental risk factors that I think should be included are alcohol consumption, age, gender, ethnicity, obesity. [[User:Taglel|Taglel]] ([[User talk:Taglel|talk]]) 14:34, 29 May 2020 (UTC)

==Sentence==
"While jaundice is usually common and harmless in infants, jaundice in adults may indicate an underlying disease."

What ref supports this? Jaundice in infants may also indicate an underlying disease and this text by juxtaposing these two makes it appear like it cannot. "usually common" does not really make sense. It is simple common and usually harmless but sometimes not harmless. [[User:Doc James|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Doc James|talk]] · [[Special:Contributions/Doc James|contribs]] · [[Special:EmailUser/Doc James|email]]) 05:49, 29 May 2020 (UTC)

:Thanks for catching this grammatical error. I completely agree that it should be stated as "Jaundice in infants is common and usually harmless (physiological)" The message I am attempting to convey in juxtaposing infant jaundice and adult jaundice was the level of concern readers may feel when exposed to a loved one with jaundice. I imagine a significant portion of readers are new mothers who may be confused by their neonate's jaundice; the most common cause being a physiologic hyperbilirubinemia caused by combination of increased fetal hemoglobin breakdown (in the first 3 months, HbF is replaced with HbA with bilirubin rising and hemoglobin drop to 10-13 g/dL) and immature hepatic conjugation and elimination (decreased uridine diphosphogluconurate glucuronosyltransferase activity). Blood disorders or genetic diseases are much less common causes of neonatal jaundice. Thus, adding "usually harmless" may be a reassuring point to put at the top in the summary. In contrast, other readers will be reading this page due to an older loved one (i.e. father, uncle, friend) with jaundice, which is likely pathophysiologic and serious. Jaundice in adults is associated with severity with up to 40% of individuals requiring intensive care experiencing jaundice either as the primary reason for ICU stay or associated with another high mortality disease process (i.e. sepsis). Also, persistence of jaundice (in general) is associated with greater morbidity and mortality. [[User:Taglel|Taglel]] ([[User talk:Taglel|talk]]) 14:49, 29 May 2020 (UTC)

::We already say "Jaundice in babies is also common with an estimated eighty percent affected during their first week of life.[7] While most cases of newborn jaundice are not harmful, if bilirubin levels are very high, brain damage — kernicterus — may occur.[8][7]"
::So we do not need "jaundice in babies is common and usually harmless" 
::We do not really need to say it twice.[[User:Doc James|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Doc James|talk]] · [[Special:Contributions/Doc James|contribs]] · [[Special:EmailUser/Doc James|email]]) 08:42, 30 May 2020 (UTC)

== Causes Section ==

The table of labs currently in the causes section may perhaps be better placed in the differential/diagnostic section, as it seems to be a separate topic. I envision the "causes/etiology" section to condensed to a summary paragraph and then list of diseases format, while the diagnostic section can detail more regarding specific labs, imaging, and differential.[[User:Taglel|Taglel]] ([[User talk:Taglel|talk]]) 13:44, 2 June 2020 (UTC)

===Prevention===
Any recommended sources for expanding the section to cover prevention, given that medication is a or the the leading cause in the developed world?--[[Special:Contributions/50.201.195.170|50.201.195.170]] ([[User talk:50.201.195.170|talk]]) 20:09, 22 April 2021 (UTC)

== Merger proposal ==
I propose merging [[Cholemia]] into [[Jaundice]]. All the sources I can find seem to use the two terms more-or-less interchangeably, sometimes even with constructions like "jaundice (cholemia)", and [[Cholemia]] is tiny and undercited.

This article is long enough as it is and would distract readers from the main purpose of this article. [[Special:Contributions/2601:642:4D80:9280:B9ED:4FD0:B8B1:1F4C|2601:642:4D80:9280:B9ED:4FD0:B8B1:1F4C]] ([[User talk:2601:642:4D80:9280:B9ED:4FD0:B8B1:1F4C|talk]]) 09:43, 14 May 2023 (UTC)

:'''Support''' merge proposal; this seems to be a rare synonym for cholestatic jaundice; as this isn't a dictionary, we don't need a page for each term. Readers arriving at [[Cholemia]] would be better served by being redirect to the information on [[Jaundice]]. [[User:Klbrain|Klbrain]] ([[User talk:Klbrain|talk]]) 17:26, 11 June 2023 (UTC)
:{{merge done}} [[User:Klbrain|Klbrain]] ([[User talk:Klbrain|talk]]) 09:14, 30 September 2023 (UTC)