View source for Talk:Clonidine

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==Heading==
I've been on a lot of medications used to treat my anxiety. The only drug that seemed to help me was Lorazapan, but over time it doesnt have nearly the same effect compared to when I first used it. Clonidine, however, has helped me and many others that are having high anxiety type issues. I just think this page needs a touch about how it can help anxiety, and also the long term effects of this specific medication.   <small>—Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/66.30.235.251|66.30.235.251]] ([[User talk:66.30.235.251|talk]]) 06:19, 13 September 2007 (UTC)</small><!-- Template:UnsignedIP --> <!--Autosigned by SineBot-->

Contrary to the article as written, I do not think Clonidine is generally used to "treat" ADHD, although many ADHD children receive it, off label at bedtime, to induce sleep. I suspect same is true with Tourette's although I am less certain of that. Although I am not qualified to prescribe, I deal with many children with both diagnoses and I only see it prescribed for use at bedtime. It is a sleep medication of choice because it does not have addictive potential and it does get the kids to slow down physically at bedtime. But I do not think any clinician would want children taking it because of ADHD during the active part of their day. Also note that clonidine and Klonopin are BOTH used to induce sleep (although not likely at the same time for the same person). 

I looked at the study cited where the citation suggests otherwise.  However that is not what the actual article says. It refers to a test of Ritalin and Clonidine used in combination. While I have not encountered this with children I have worked with (unless the Clonidine was administered only at bedtime) the COMBINATION makes sense.  But I still doubt that Clonidine, by itself, is an appropriate treatment for either disorder.  [[User:70.90.220.214|70.90.220.214]] 22:04, 27 March 2007 (UTC)

There is a lot of info on this page[[http://www.angelfire.com/journal2/sadhelp/clonidine.htm]]
--[[User:Clawed|Clawed]] 05:07, 16 Jul 2004 (UTC)

:Unless I got the wrong drug, Clonidine is also used [[off-label]] to treat [[insomnia]]. I once took it when I was young in really small doses. --[[User:Arm]]

::You're probably thinking of [[clonazepam]] (Klonopin). - [[User:Nunh-huh|Nunh-huh]] 05:43, 3 Mar 2005 (UTC)

:::I was recently (yesterday) perscribed Clonidine by my psychiatrist for dealing with panic attacks and additionally to help with insomnia -- Anonymous 19:44, 3 February 2006 (UTC)

clonidine can be used for ADHD treatment and tics treatment in children(Dr Hussein Abdeldayem , Alex, Egypt)


I was prescribed clonidine specifically for my mild Tourette's syndrome, and it works very well.
[[User:VCUchem|VCUchem]] 03:28, 10 April 2007 (UTC)

My son, 4.5 years old, has been on clonidine for two week to treat ADD, his prescription is 0.05mg.  It is working well, but worried about longterm negative effects. Any articles? (user:woodmac)(December 18 2008)

Clonidine Transdermal "patch" .3 Is currently being used to treat my daughter's Cycling Vomiting Syndrome. see ref: http://digestive.niddk.nih.gov/ddiseases/pubs/cvs/#6  <small>—Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[User:Morrisindustries|Morrisindustries]] ([[User talk:Morrisindustries|talk]] • [[Special:Contributions/Morrisindustries|contribs]]) 12:11, 15 January 2008 (UTC)</small><!-- Template:Unsigned --> <!--Autosigned by SineBot-->

== Quitting smoking ==
The Surgeon General suggests that Clonidine can be used to aid in quitting smoking after nicotine replacement methods have failed. A potential source is http://surgeongeneral.gov/tobacco/treating_tobacco_use.pdf

== Side-effects? ==

Did anyone ever hear of very bad chest and back pain with this medicine?  Taking it four times a day, and my upper back and chest is killing me

Your side effect was probably a rare reaction.  The only side effect I experienced was being extremely tired at first.  

The most popular understated side effect of this medication is, for lack any milder way to put it, catastrophic loss of consciousness. Not so much "put them out like a light", but more like drop them like a punch from Mike Tyson, where they stand.   <span style="font-size: smaller;" class="autosigned">— Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/208.127.80.59|208.127.80.59]] ([[User talk:208.127.80.59|talk]]) 11:57, 27 September 2011 (UTC)</span><!-- Template:Unsigned IP --> <!--Autosigned by SineBot-->

[[User:VCUchem|VCUchem]] 03:24, 10 April 2007 (UTC)

== Cleanup ==

This page is a candidate for cleanup. I propose that all of the [[benzodiazepines]] be wikified at once. The benzodiazepines are a significant family of drugs, and better information should be available here on Wikipedia, due to their widespread use.

: Clonidine is not a benzodiazepine.
You must be thinking of Klonopin (clonazepam).

[Speaking of which, does clonodine actually treat restless leg syndrome? or is that another klonopin accident? On the Restless legs syndrome wiki, clonidine is not mentioned...]  <!-- Template:Unsigned IP --><small class="autosigned">—&nbsp;Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/212.179.160.18|212.179.160.18]] ([[User talk:212.179.160.18#top|talk]]) 08:05, 5 June 2018 (UTC)</small> <!--Autosigned by SineBot-->
 
I agree that a lot of people do not understand that Klonopin is a completely different medication than clonadine!
:Clonidine can indeed be used in the treatment of RLS. I've cited this statement in the article to clarify the point. Thank you for the notification! ―[[User:Biochemistry&amp;Love|<span style="letter-spacing:1px"><span style="color:Teal">'''Bio'''</span><span style="color:seagreen">chemistry</span><span style="color:Teal">🙴</span><span style="color:firebrick">❤</span></span>]] 23:37, 3 October 2018 (UTC)

== Creditation ==

Clonidine is often used to treat tics, specifically Tourettes Disorder, due to research by Dr. Richard Ferre, M.D. of University of Utah. I do not have a link to the specific paper, but you can find it on a Google search "Richard Ferre"

Yea, i have Tourettes and i take this. [[User:EvilHom3r|EvilHom3r]] 18:49, 6 August 2007 (UTC)

I have used the patch form of this medicine before to treat parts/symptoms of Attention Deficit Hyperactivity Disorder, and it seems to work pretty well. User: mansharker8  <small>—Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/207.157.138.39|207.157.138.39]] ([[User talk:207.157.138.39|talk]]) 01:35, 30 October 2007 (UTC)</small><!-- Template:UnsignedIP --> <!--Autosigned by SineBot-->

== Clean-Up (again?) ==
The muddle with clonazepam (Klonopin) here remains - for a start, one of the most common side effects of clonidine is insomnia (see the [[British National Formulary]] entry - probably same info listing in the Physicians Desk Ref too...) and I can hardly see it being rx'd for such. Indeed, its one of the drawbacks of using it for opiate withdrawal as the resultant insomnia can be severe and prolonged even after the acute symptons are over. In the UK, it is usually therefore prescribed for this purpose along with strong benzos such as Rohypnol or with benzo/chlorpromazine combinations to overcome this lack of efficacy. Anyway, someone ought to clear this up some more. If no-one better qualied tries, 'll come back and have a go. [[User:Plutonium27|Plutonium27]] ([[User talk:Plutonium27|talk]]) 02:47, 5 June 2008 (UTC)

== Adrenergic Agonist AND NE antagonist? ==

How is this drug a "α2 adrenergic agonist" AND "inhibits the release of norepinephrine (NE)". Can someone explain?  <span style="font-size: smaller;" class="autosigned">—Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/144.126.53.164|144.126.53.164]] ([[User talk:144.126.53.164|talk]]) 11:51, 20 October 2009 (UTC)</span><!-- Template:UnsignedIP --> <!--Autosigned by SineBot-->

In response to "Adrenergic Agonist AND NE antagonist?" I was wondering the same thing, as I'm at work researching Clonidine. I found this on a website: "Clonidine is an agonist, an alpha-2 agonist to be precise. But it acts primarily on noradrenergic autoreceptors thereby decreasing norepinephrine release. Thus clonidine is a direct-acting a2-noradrenergic agonist with indirect-acting antagonist action at other noradrenergic targets. (It has the physiological/behavioral effect of an antagonist at most doses, but it's still technically an agonist!) "  <span style="font-size: smaller;" class="autosigned">—Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/216.63.110.9|216.63.110.9]] ([[User talk:216.63.110.9|talk]]) 07:33, 15 January 2010 (UTC)</span><!-- Template:UnsignedIP --> <!--Autosigned by SineBot-->

== Clonodine ==

Clonodine is not Klonopin (clonazepam), it is not a benzodiazepine like (Valium, diazepam, Xanax, alprazolam, Ativan, lorazepam). etc... Clonidine is used alone or in combination with other medications to treat high blood pressure. Clonidine is in a class of medications called centrally acting alpha-agonist hypotensive agents. It works by decreasing your heart rate and relaxing the blood vessels so that blood can flow more easily through the body.
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000623  <small><span class="autosigned">—Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[User:Jodiah|Jodiah]] ([[User talk:Jodiah|talk]] • [[Special:Contributions/Jodiah|contribs]]) 20:47, 29 June 2010 (UTC)</span></small><!-- Template:Unsigned --> <!--Autosigned by SineBot-->

:bu ilacı hangi ülkeden ve hangi eczaneden temin edebiliriz  reçetemiz var ilaç bulamıyoruz catapresan [[Special:Contributions/78.190.150.221|78.190.150.221]] ([[User talk:78.190.150.221|talk]]) 18:32, 28 September 2024 (UTC)

== Structure ==

{{resolved|The offending 3D structure was deleted {{oldid|Clonidine|427410699|here}}. I see no difference between the two models in the current article.―[[User:Biochemistry&amp;Love|<span style="letter-spacing:1px"><span style="color:Teal">'''Bio'''</span><span style="color:seagreen">chemistry</span><span style="color:Teal">🙴</span><span style="color:firebrick">❤</span></span>]] 05:29, 11 July 2018 (UTC)}}
{{archive top}} 
I'm no expert, but do the two structure models agree? The 3D model shows both N atoms of the imidazoline ring with H's (implying imidazolidine), whereas the planar model shows N at position 2 with no H (imizazoline). The 3D model shows the N of the amine with no H and the planar model shows it with one.  <span style="font-size: smaller;" class="autosigned">—Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/220.244.145.200|220.244.145.200]] ([[User talk:220.244.145.200|talk]]) 00:38, 8 December 2010 (UTC)</span><!-- Template:UnsignedIP --> <!--Autosigned by SineBot-->

You are absolutely right. It is a mistake and should be corrected.  The 3D model is missing one H atom.<!-- Template:Unsigned --><small class="autosigned">—&nbsp;Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[User:209.175.69.2|209.175.69.2]] ([[User talk:209.175.69.2#top|talk]] • [[Special:Contributions/209.175.69.2|contribs]]) 19:04, 28 April 2011 (UTC)</small> 
{{archive bottom}}

== Uses ==
There are two "Uses" paragraphs in the article.
Should be restructured.  <small><span class="autosigned">— Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[User:Vbond|Vbond]] ([[User talk:Vbond|talk]] • [[Special:Contributions/Vbond|contribs]]) 06:25, 3 February 2011 (UTC)</span></small><!-- Template:Unsigned --> <!--Autosigned by SineBot-->


Other uses: I deleted everything but RLS, as the others were all mentioned in the "Uses" section. I propose that "Uses" should be for approved uses and "other uses" for off-label uses, as this is often how drug articles are structured.  <span style="font-size: smaller;" class="autosigned">— Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/74.76.210.124|74.76.210.124]] ([[User talk:74.76.210.124|talk]]) 04:49, 6 February 2012 (UTC)</span><!-- Template:Unsigned IP --> <!--Autosigned by SineBot-->

== Clonidine in combination with Methedone or Suboxone ==

Clonidine is also given in conjuction with methedone/suboxone to combat excessive persperation. It is rarely given alone to combat the affects of opioid withdrawls. When combined with methedone/suboxone it has shown evidence of improving comfort levels when it comes to exessive persperation. The typical does when combine with methedone is 0.1-0.2 micrograms twice daily.  <span style="font-size: smaller;" class="autosigned">— Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/174.115.132.133|174.115.132.133]] ([[User talk:174.115.132.133|talk]]) 20:07, 12 October 2011 (UTC)</span><!-- Template:Unsigned IP --> <!--Autosigned by SineBot-->
:I don't believe that the article claims that clonidine is used as monotherapy for opioid withdrawal, so I don't really see the point of your comment. However, it is not unusual for clonidine to be used alone; [[opioid substitution therapy]] isn't necessarily always employed. ―[[User:Biochemistry&amp;Love|<span style="letter-spacing:1px"><span style="color:Teal">'''Bio'''</span><span style="color:seagreen">chemistry</span><span style="color:Teal">🙴</span><span style="color:firebrick">❤</span></span>]] 23:32, 3 October 2018 (UTC)

== External links modified ==

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== Citation update  ==

Does there exist any more-recent paper that supports the citation no.2 - Lowenthal, DT; Matzek, KM; MacGregor, TR (May 1988). "Clinical pharmacokinetics of clonidine.". Clinical Pharmacokinetics. 14 (5): 287–310. {{PMID|3293868}}. doi:10.2165/00003088-198814050-00002 ?  Thanks! : )  --[[User:It's gonna be awesome|<span style="color:#00cc7a; font-family:Lucida Handwriting; background-color:#ffffcc;size:12pt">It's gonna be awesome!</span>]]✎[[User talk:It's gonna be awesome|<span style="text-shadow:0 1px 5px #39f;">Talk♬</span>]] 16:32, 8 September 2017 (UTC)

== slow pulse ==

Other sources say that clonidine makes pulse get slower because of more action by the vagus nerve. This article says the idea that clonidine slows the heart because of tightening of the arteries but there is no reference. Which is right?  <!-- Template:Unsigned IP --><small class="autosigned">—&nbsp;Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/152.133.8.193|152.133.8.193]] ([[User talk:152.133.8.193#top|talk]]) 16:18, 15 July 2018 (UTC)</small> <!--Autosigned by SineBot-->
:Very observant. It's my understanding that this isn't all too-well understood; it may indeed be a combination of multiple mechanisms, including those. A paper from 1995 notes the following:
{{quote
|text=The exact mechanism responsible for this clonidine-associated bradycardia is not well understood. The most plausible mechanisms are: (a) reduced sympathetic tone from central mediators, (b) increased vagal activity, (c) stimulation of presynaptic alpha-2 receptors in the heart which have a blocking effect on heart rate, (d) decreased automaticity of the bundles of His, and (e) atrioventricular nodal block. It is probable that the mechanisms vary from patient to patient. 
|author=Lawrence L. Golusinski, Jr. and B. Wayne Blount |title="Clonidine-induced bradycardia"|source=[https://www.ncbi.nlm.nih.gov/pubmed/7561715 source]
}}
:If anyone can find a more recent source to confirm this speculation, it would be greatly appreciated. ―[[User:Biochemistry&amp;Love|<span style="letter-spacing:1px"><span style="color:Teal">'''Bio'''</span><span style="color:seagreen">chemistry</span><span style="color:Teal">🙴</span><span style="color:firebrick">❤</span></span>]] 18:53, 15 July 2018 (UTC)

== Which receptor? ==

[[User:Sbelknap]] what are your thoughts on [https://en.wikipedia.org/w/index.php?title=Clonidine&diff=prev&oldid=854014870 this diff]? [[User:Jytdog|Jytdog]] ([[User talk:Jytdog|talk]]) 13:42, 8 August 2018 (UTC)
:Fixed. Interesting, as there seems to be an error in this low-quality article, so I've removed the citation. The best citation is the Goodman and Gilman one on page 202 of the 13th edition. Its post-synaptic alpha 2 agonism in vascular smooth muscle that gives the transient rise in blood pressure. I notice that John Reid mentions both mechanisms in his article<ref>B. J. clin. Pharmac. (1981), 12, 295-302 THE FOURTH LILLY PRIZE LECTURE, UNIVERSITY OF ABERDEEN, SEPTEMBER 1980 THECLINICALPHARMACOLOGYOFCLONIDINEAND RELATED CENTRAL ANTIHYPERTENSIVE AGENTS JOHN L.REID DepartmentofMateriaMedica, UniversityofGlasgow,Glasgow,Scotland</ref>, citing Doxey et al for the alpha 1 mechanism <ref>DOXEY, J.C. (1979). Pre and postsynaptic effect of alpha agonists in the anococcygeus muscle of the pithed rat. Eur.J.Pharmac.,54,185-189.</ref> and citing Drew and Whiting <ref>DREW, G.M. & WHITING, S.B. (1979). Evidence for two distinct types of postsynaptic a-adrenoceptors in vascular smooth muscle in vivo. Br. J. Pharmac., 67, 207-215.</ref> for the post-synaptic alpha 2 mechanism. I'll ask Tom Westfall, who wrote the Goodman and Gilman chapter, what he thinks. [[User:Sbelknap|Sbelknap]] ([[User talk:Sbelknap|talk]]) 18:12, 11 August 2018 (UTC)

{{reflist}}

== Semantic Scholar ==

{{U|Afernand74}} The Semantic Scholar PDF is not the article. It is just the abstract. It is misleading and confusing to click on the link and end up on a random unrelated site that doesn't provide the article. --[[User:Whywhenwhohow|Whywhenwhohow]] ([[User talk:Whywhenwhohow|talk]]) 20:05, 12 September 2020 (UTC)
: The Citation bot added the s2cid and reports that the Semantic Scholar URL is not licensed. I am removing the unlicensed URL. --[[User:Whywhenwhohow|Whywhenwhohow]] ([[User talk:Whywhenwhohow|talk]]) 20:51, 12 September 2020 (UTC)
:{{tq2|1=   + Adding s2cid: 40756251<br/>   ! Should probably remove un-licensed Semantic Scholar URL that was converted to S2CID parameter}}

== Conflicting structural formulae ==

Stick and ball strucutural formula shows the bridging Nitrogen without a Hydrogen.  It shows both ring Nitrogens with a Hydrogen.

Letter structural formula shows bridge Nitrogen with a Hydrogen and one of the ring Nitrogens without a Hydrogen.

The following, currently reference 1, puts the Hydrogen on the bridging Nitrogen.

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d7f569dc-6bed-42dc-9bec-940a9e6b090d

[[Special:Contributions/2600:387:B:9A2:0:0:0:9|2600:387:B:9A2:0:0:0:9]] ([[User talk:2600:387:B:9A2:0:0:0:9|talk]]) 08:46, 3 August 2021 (UTC) Drive By Editor

== Selectivity ==
{{u|Димитрий Улянов Иванов}}, you keep changing the "alpha-2 agonist" to "alpha-2a agonist". The issue is the body doesn't support the selectivity for 2a (as it does in the guanfacine article). If you want to keep changing it to alpha-2a, please provide a source that supports clonidine being more selective for alpha-2a than the others.
[[User:Kimen8|Kimen8]] ([[User talk:Kimen8|talk]]) 13:33, 22 November 2023 (UTC)

:My apologies, it does indicate alpha-2a selectivity. [[User:Kimen8|Kimen8]] ([[User talk:Kimen8|talk]]) 15:24, 24 November 2023 (UTC)

== Depression ==

In Germany a depression is considered a contraindication to clonidine. This seems plausible because of the old-school depression theory of a cerebral lack of sympathetic neuro-transmitters. 
Interestingly dexmedetomidine, having the same or similar pharmacodynamics, is now a candidate for treatment of otherwise non-treatable depression. 
Could someone elaborate on that? [[User:Elmar Hagemeyer|Elmar Hagemeyer]] ([[User talk:Elmar Hagemeyer|talk]]) 12:52, 23 June 2024 (UTC)