View source for Talk:Chemoreceptor

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== Chemoreceptor resetting ==

Would it be worth having a section on how the baseline rate of [[action potentials]] from chemoreceptors changes from the [[foetus]] to the [[neonate]]? This is well-studied in the scientific literature,<ref>{{cite book |last1=Hanson |first1=Mark |last2=Kumar |first2=Prem |title=Arterial Chemoreceptors |isbn=978-1-4615-2572-1 |url=https://doi.org/10.1007/978-1-4615-2572-1 |access-date=29 December 2020 |chapter=Chemoreceptor Function in the Fetus and Neonate}}</ref><ref>{{cite journal |last1=Carroll |first1=John L. |last2=Sterni |first2=Laura M. |last3=Bamford |first3=Owen S. |last4=Montrose |first4=Marshall H. |title=Mechanisms of carotid chemoreceptor resetting after birth: In vitro studies |journal=Advances in experimental medicine and biology |date=1 December 1996 |volume=410 |page=73-77 |url=https://jhu.pure.elsevier.com/en/publications/mechanisms-of-carotid-chemoreceptor-resetting-after-birth-in-vitr-4 |access-date=29 December 2020 |issn=0065-2598}}</ref><ref>{{cite journal |last1=Carroll |first1=J. L. |last2=Bamford |first2=O. S. |last3=Fitzgerald |first3=R. S. |title=Postnatal maturation of carotid chemoreceptor responses to O2 and CO2 in the cat |journal=Journal of Applied Physiology |date=1 December 1993 |volume=75 |issue=6 |pages=2383–2391 |https://doi.org/10.1152/jappl.1993.75.6.2383 |url=https://journals.physiology.org/doi/abs/10.1152/jappl.1993.75.6.2383 |access-date=29 December 2020}}</ref> and may be relevant to [[Sudden infant death syndrome]]. I'm not sure where to start in adding this content to the article. [[User:Bibeyjj|Bibeyjj]] ([[User talk:Bibeyjj|talk]]) 16:11, 29 December 2020 (UTC)
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I would say "no". All 3 publications are primary research, and the conclusions are speculative and unencyclopedic. [[User:Zefr|Zefr]] ([[User talk:Zefr|talk]]) 17:12, 29 December 2020 (UTC)

== Gasoreceptor ==

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* Specific text to be added or removed: Recently, the term gasoreceptor for [[protein]]-based chemoreceptors that can directly bind to [[gaseous signaling molecules]] and trigger [[Cell signaling|cellular signaling]] was proposed.<ref>{{cite journal |last1=Anbalagan |first1=S |title=Heme-based oxygen gasoreceptors. |journal=American journal of physiology. Endocrinology and metabolism |date=17 January 2024 |doi=10.1152/ajpendo.00004.2024 | s2cid = 267032865 |pmid=38231000 |url=https://doi.org/10.1152/ajpendo.00004.2024}}</ref> However, this term is not widely used in the scientific literature. Examples of gasoreceptor includes ''C. elegans'' molecular O<sub>2</sub> receptor guanylyl cyclase GCY-35 and molecular CO<sub>2</sub> receptors guanylyl cyclase GCY-9.<ref>{{cite journal |last1=Carrillo |first1=MA |last2=Hallem |first2=EA |title=Gas sensing in nematodes. |journal=Molecular neurobiology |date=2015 |volume=51 |issue=3 |pages=919-31 |doi=10.1007/s12035-014-8748-z |pmid=24906953 |url=https://doi.org/10.1007/s12035-014-8748-z}}</ref>

* Reason for the change: Gasoreceptor is a new term for protein-based receptors that can bind and sense gaseous molecule. This term will allow to distinguish between chemoreceptor cells vs protein-based gasoreceptors. 
* References supporting change: <ref>{{cite journal |last1=Anbalagan |first1=S |title=Heme-based oxygen gasoreceptors. |journal=American journal of physiology. Endocrinology and metabolism |date=17 January 2024 |doi=10.1152/ajpendo.00004.2024 | s2cid = 267032865 |pmid=38231000 |url=https://doi.org/10.1152/ajpendo.00004.2024}}</ref><ref>{{cite journal |last1=Carrillo |first1=MA |last2=Hallem |first2=EA |title=Gas sensing in nematodes. |journal=Molecular neurobiology |date=2015 |volume=51 |issue=3 |pages=919-31 |doi=10.1007/s12035-014-8748-z |pmid=24906953 |url=https://doi.org/10.1007/s12035-014-8748-z}}</ref>

[[User:Zebrafishgroup|Zebrafishgroup]] ([[User talk:Zebrafishgroup|talk]]) 13:20, 21 January 2024 (UTC)

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:The Anbalagan article is not a [[WP:SCIRS]] review, but an opinion about a hypothetical receptor. [[Peripheral_chemoreceptors#Microanatomy|Chemoreceptors]] like the carotid or aortic sinuses can actually be identified anatomically, and resected for experimental or clinical purposes. Gasoreceptors exist as a theoretical concept. The argument for a physical cellular entity is not convincing, as there could be other ways a gas evokes a cellular response, such as a change in partial pressure or enzyme sensitivity, neither of which requires a receptor. [[User:Zefr|Zefr]] ([[User talk:Zefr|talk]]) 18:24, 21 January 2024 (UTC)
::Soluble guanylyl cyclase is the protein gasoreceptor for nitric oxide. Gasoreceptor is not an hypothetical or theoritcal term. It is a new classification for protein-based receptors that can bind and sense gas in a cell. [[Special:Contributions/31.0.176.28|31.0.176.28]] ([[User talk:31.0.176.28|talk]]) 18:45, 21 January 2024 (UTC)
::likewise in C. elegans GCY35 is the molecular oxygen sensor, a protein gasoreceptor. The moderator is not aware of the literature cited in the Anbalagan manuscript. [[Special:Contributions/31.0.176.28|31.0.176.28]] ([[User talk:31.0.176.28|talk]]) 19:18, 21 January 2024 (UTC)
:::Under [[WP:BURDEN]], it is the responsibility of an editor to provide a reputable review to support content. The concept of a gasoreceptor is in development. Advocates for the concept appear to be using Wikipedia to report preliminary research, countering [[WP:NOTJOURNAL]] #6-7. [[User:Zefr|Zefr]] ([[User talk:Zefr|talk]]) 19:58, 21 January 2024 (UTC)
::The text has been revised and secondary references has been added for receptors for O2 and CO2. [[User:Zebrafishgroup|Zebrafishgroup]] ([[User talk:Zebrafishgroup|talk]]) 21:50, 21 January 2024 (UTC)
:::The Anbalagan article is a "perspectives" discussion (see top of page in AJP), i.e., a statement of an hypothesis, and is in press as of this date, i.e., not published. The Carillo article is primary research in a lab model animal. A rigorous review and further evidence of this hypothetical concept by an independent source are needed. 
:::Further, as Zebrafishgroup has declared a conflict of interest, no further editing of this or related articles about this concept should occur without first obtaining consensus on the respective talk page, [[WP:CON]]. [[User:Zefr|Zefr]] ([[User talk:Zefr|talk]]) 22:36, 21 January 2024 (UTC)
::::Carillo article is a '''review '''article and not a primary research.
::::Gas sensing in nematodes.
::::Carrillo MA, Hallem EA.Mol Neurobiol. 2015;51(3):919-31. doi: 10.1007/s12035-014-8748-z. Epub 2014 Jun 8.PMID: 24906953 '''Review'''.
::::Gasoreceptor is '''not ''' an hypothetical concept. [[User:Zebrafishgroup|Zebrafishgroup]] ([[User talk:Zebrafishgroup|talk]]) 22:44, 21 January 2024 (UTC)
:::::The author approved version of the manuscript is already published online in AJP journal. [[User:Zebrafishgroup|Zebrafishgroup]] ([[User talk:Zebrafishgroup|talk]]) 22:46, 21 January 2024 (UTC)
::::::[[Draft_talk:Gasoreceptor|A draft for a gasoreceptor article has been denied]] by an administrator, with the comments {{tq|''Savani Anbalagan is the only author that used this term. Until other people from other groups publish on this topic as well, it is not shown to be notable. There is probably not enough publication for it to get a a Wiktionary entry.''}} 
::::::Other draft articles on gas-related chemoreceptors composed by Zebrafishgroup have also been rejected as non-notable, unsupported by SCIRS reviews, and "unambiguous advertising or promotion: self written vanity", [[WP:COI]]. We can end this discussion now. [[User:Zefr|Zefr]] ([[User talk:Zefr|talk]]) 17:48, 22 January 2024 (UTC)
:{{Respond|xmark|Not done:}} <!-- Template:ECOI -->In light of the above discussion, it seems that inclusion of this novel concept is premature.   <span style="border-radius:9em;padding:0 8px;background:#ffdc9e">[[User:WhinyTheYounger|WhinyTheYounger]] ※ <small>[[User:WhinyTheYounger|Talk]]</small></span> 16:49, 27 January 2024 (UTC)