View source for Talk:Cellular differentiation

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[[Category:Top-importance and Start-Class MCB articles|Cellular differentiation]]

==Untitled==
Thanks Cordyph and mav --adam

?????????????????????????????????????????????????????????  <!-- Template:Unsigned --><small class="autosigned">—&nbsp;Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[User:SAVAGECoen4324|SAVAGECoen4324]] ([[User talk:SAVAGECoen4324#top|talk]] • [[Special:Contributions/SAVAGECoen4324|contribs]]) 14:07, 7 May 2020 (UTC)</small> <!--Autosigned by SineBot-->

==Grading==
Anyone object if I split the grading section into its own page? --[[User:Arcadian|Arcadian]] 03:24, 29 November 2005 (UTC)

==Overview section==
Some of the HTML displays improperly at the bottom of the page looking like this:

Navbox |name = Stem cells | groupstyle = background-color: #F8BFF8;



the entire overview section is plagiarized from the cited source. Can someone fix this? I don't have time right now.  <small>—Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/71.111.116.145|71.111.116.145]] ([[User talk:71.111.116.145|talk]]) 23:36, 1 November 2007 (UTC)</small><!-- Template:UnsignedIP --> <!--Autosigned by SineBot-->

Can someone please remove the stuff under ((Sources))? I tried, but it does not show in my edit page.
thanks
[[User:Weeddude|Weeddude]] ([[User talk:Weeddude|talk]]) 16:31, 29 November 2007 (UTC)
:Fixed.  Someone vandalized the Stem cell template.  It couldn't be fixed from this page.   [[User:Forluvoft|Forluvoft]] ([[User talk:Forluvoft|talk]]) 16:38, 29 November 2007 (UTC)

== Merging ==

I've suggested to merge [[Dedifferentiation|de-differentiation]] with cellular differentiation. I was also thinking that the article on [[Cell fate determination|Cell Fate Determination]] may also be a good article to merge here since the ideas are almost the same. Suggestions?
[[User:AkashAD|AkashAD]] ([[User talk:AkashAD|talk]]) 18:44, 24 December 2007 (UTC)
:Yes, go ahead and merge all three. --[[User:JWSchmidt|JWSchmidt]] ([[User talk:JWSchmidt|talk]]) 01:15, 25 December 2007 (UTC)

:[[Dedifferentiation|de-differentiation]] has been merged. --[[User:EncycloPetey|EncycloPetey]] ([[User talk:EncycloPetey|talk]]) 20:55, 2 January 2008 (UTC)

== Mechanism... ==

Can someone please add an explanation of how and why differentiation occurs.  That's what I came here looking for. Thanks. '''[[User:ReluctantPhilosopher|<span style="color:#ee7700;">Amit</span>]]<span style="background: #ffffff; color: #3680f0;">@</span>[[User_talk:ReluctantPhilosopher|<span style="color: #009980;">Talk</span>]]'''<span style="color: black;"></span> 19:54, 2 January 2008 (UTC)
:Yes, you are correct, this is a big hole in the article. Part of the problem is that there is very active research into the mechanisms of cell differentiation and one major conclusion that can be drawn from that research program is that very many mechanisms for control of cell differentiation have been invented during the past billion years....and many of the good ones continue to be used. Still, it is worth having an introduction to what has been learned so far. For a typical textbook approach, see: [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?highlight=Specification,Cell-Type,Animals&rid=mcb.section.3772 Cell-Type Specification in Animals]<BR>--[[User:JWSchmidt|JWSchmidt]] ([[User talk:JWSchmidt|talk]]) 20:25, 2 January 2008 (UTC)

:There also is little coordination of findings or even approaches between study of differentiation in plants, insects, and mammals, which is where most of the research occurs.  Even someone very intimately familiar with one of these three areas may be completely unaware of advances in the other two. --[[User:EncycloPetey|EncycloPetey]] ([[User talk:EncycloPetey|talk]]) 20:57, 2 January 2008 (UTC)

EDIT Question— What of the work of [[Robert O. Becker]], exploring dedifferentiation in his 1998 work [[The Body Electric]]?
"The electric field changes turned out to be caused by currents in the nerves, and the limb regeneration occurred from red blood cells, which first dedifferentiated into unspecialized cells, and then differentiated into the new cells needed."  <span style="font-size: smaller;" class="autosigned">— Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/198.53.36.67|198.53.36.67]] ([[User talk:198.53.36.67|talk]]) 00:33, 16 August 2011 (UTC)</span><!-- Template:Unsigned IP --> <!--Autosigned by SineBot-->

:Information about [[Dedifferentiation]] would go in that article, not in this one. --[[User:EncycloPetey|EncycloPetey]] ([[User talk:EncycloPetey|talk]]) 03:56, 16 August 2011 (UTC)
hi

== Article organization ==

I've been thinking about how to organize this article.  The whole subject seems a bit chaotic, especially considering that mammals, plants, insects, etc. all have different ways of doing things (as mentioned above).  But I think, fundamentally, to answer the question of cellular differentiation you must answer the following questions:
* How does a cell know what type it is?  
(chromatin structure, DNA modifications, other forms of epigenetics, ???)
* How does a cell know what other types it can become?  
(maybe the same as above?  do we even know???)
* How does a cell know what cell type to become and when?  
(cell-cell communication, ???)
* How does a cell actually differentiate?  
(mechanisms of gene regulation, ???)


Maybe this can help organize the article.  Other thoughts?   [[User:Forluvoft|Forluvoft]] ([[User talk:Forluvoft|talk]]) 16:34, 4 January 2008 (UTC)

== Single Celled Organisms ==
Would it be appropriate to include a brief discussion of cellular differentiation in single celled critters?  I know many microbes have multiple life stages with drastically different morphologies and behaviors (such as my favorite, the amobeobo-flagellate naegleria).  As it stands, this article only addresses multicellular organisms. [[User:Fritzlaylin|Fritzlaylin]] ([[User talk:Fritzlaylin|talk]]) 22:10, 15 January 2008 (UTC)
:Sounds good!    [[User:Forluvoft|Forluvoft]] ([[User talk:Forluvoft|talk]]) 22:32, 15 January 2008 (UTC)
:But differentiation ''by definition'' is change in the cells of a ''single'' organism, not changes between different stages.  That's not to say there isn't relevant material (such as you've proposed), just a caution that not all such changes qualify as differentiation. --[[User:EncycloPetey|EncycloPetey]] ([[User talk:EncycloPetey|talk]]) 01:41, 16 January 2008 (UTC)

== Signal Transduction Pathways ==

I believe a section discussing the importance of signal transduction pathways, including the [[Receptor Tyrosine Kinase|RTK pathway]] and others, in providing transcription factors for the activation of particular genes that help differentiate a cell. I know it is briefly mentioned in the '''Mechanisms''' section, but I think it is important enough to merit its own discussion.
-[[User:Estephe9|Estephe9]] ([[User talk:Estephe9|talk]]) 17:33, 2 February 2014 (UTC)

== Added section on matrix-induced differentiation ==
I noticed that this article does not mention differentiation induced by matrix ductility or mechanical factors. This seems like an important component of current knowledge of cellular differentiation so I went ahead and added a section to the page. Additional feedback or perspectives on this issue are welcome. 
[[User:FujiOrBraeburn|FujiOrBraeburn]] ([[User talk:FujiOrBraeburn|talk]]) 14:41, 22 April 2016 (UTC)

==Assessment comment==
{{Substituted comment|length=126|lastedit=20070429035150|comment=Rated "top" as highschool topic and important concept in cell biology. - [[User:Tameeria|tameeria]] 03:51, 29 April 2007 (UTC)}}
Substituted at 11:08, 29 April 2016 (UTC)

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