View source for TIE1

{{infobox_gene}}
{{infobox protein
|Name=tyrosine kinase with immunoglobulin-like and EGF-like domains 1
|caption=
|image=
|width=
|HGNCid=11809
|Symbol=TIE1
|AltSymbols=TIE, JTK14
|EntrezGene=7075
|OMIM=600222
|RefSeq=NM_005424
|UniProt=P35590
|PDB=
|ECnumber=2.7.1.112
|Chromosome=1
|Arm=p
|Band=34
|LocusSupplementaryData=-p33
}}
'''Tyrosine kinase with immunoglobulin-like and EGF-like domains 1''' also known as '''TIE1''' is an [[angiopoietin receptor]] which in humans is encoded by the ''TIE1'' [[gene]].<ref name="pmid1312667">{{cite journal | vauthors = Partanen J, Armstrong E, Mäkelä TP, Korhonen J, Sandberg M, Renkonen R, Knuutila S, Huebner K, Alitalo K | title = A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains | journal = Molecular and Cellular Biology | volume = 12 | issue = 4 | pages = 1698–707 | date = April 1992 | pmid = 1312667 | pmc = 369613 | doi =  10.1128/mcb.12.4.1698}}</ref>

== Function ==

TIE1 is a cell surface protein expressed exclusively in [[endothelium|endothelial]] cells, however it has also been shown to be expressed in immature [[hematopoietic cells]]<ref>{{cite journal | vauthors = Rodewald HR, Sato TN | title = Tie1, a receptor tyrosine kinase essential for vascular endothelial cell integrity, is not critical for the development of hematopoietic cells | journal = Oncogene | volume = 12 | issue = 2 | pages = 397–404 | date = January 1996 | pmid = 8570217 }}</ref> and platelets.<ref name="pmid11146396">{{cite journal | vauthors = Tsiamis AC, Hayes P, Box H, Goodall AH, Bell PR, Brindle NP | title = Characterization and regulation of the receptor tyrosine kinase Tie-1 in platelets | journal = Journal of Vascular Research | volume = 37 | issue = 6 | pages = 437–42 | date = 2000 | pmid = 11146396 | doi = 10.1159/000054075 | s2cid = 43509019 }}</ref> TIE1 upregulates the [[cell adhesion molecule]]s (CAMs) [[VCAM-1]], [[E-selectin]], and [[ICAM-1]]  through a [[p38 mitogen-activated protein kinases|p38]]-dependent mechanism. Attachment of [[monocyte]] derived immune cells  to endothelial cells is also enhanced by TIE1 expression. TIE1 has a proinflammatory effect and may play a role in the endothelial inflammatory diseases such as [[atherosclerosis]].<ref name="pmid18448073">{{cite journal | vauthors = Chan B, Yuan HT, Ananth Karumanchi S, Sukhatme VP | title = Receptor tyrosine kinase Tie-1 overexpression in endothelial cells upregulates adhesion molecules | journal = Biochemical and Biophysical Research Communications | volume = 371 | issue = 3 | pages = 475–9 | date = July 2008 | pmid = 18448073 | doi = 10.1016/j.bbrc.2008.04.091 | bibcode = 2008BBRC..371..475C }}</ref>

== See also ==
* {{section link|Angiopoietin|Tie pathway}}

== References ==
{{Reflist}}

== External links ==
* {{MeshName|Receptor,+TIE-1}}

{{Tyrosine kinases}}
{{Enzymes}}
{{Portal bar|Biology|border=no}}

[[Category:Tyrosine kinase receptors]]
[[Category:Proteins]]