View source for Stamulumab

{{Short description|Monoclonal antibody}}
{{Drugbox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 470470459
<!-- Monoclonal antibody data -->
| type = mab
| mab_type = mab
| source = u
| target = [[myostatin]]
<!-- Clinical data -->
| tradename =  
| routes_of_administration = injection only
<!-- Identifiers -->
| CAS_number_Ref = {{cascite|changed|??}}
| CAS_number = 705287-60-1
| ATC_prefix = none
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = V43X8G4797
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D05917
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
| ChemSpiderID = none
<!-- Chemical data -->
| C=6330 | H=9748 | N=1672 | O=1668 | S=48
}}

'''Stamulumab''' ('''MYO-029'''<ref name="Wyeth Pipeline">[http://www.wyeth.com/research/pipeline Wyeth Product Pipeline] {{Webarchive|url=https://web.archive.org/web/20070509163323/http://www.wyeth.com/research/pipeline |date=2007-05-09 }}, [[Wyeth]], Website accessed April 22, 2007</ref>) is an experimental [[myostatin]] inhibiting drug developed by [[Wyeth|Wyeth Pharmaceuticals]] for the treatment of [[muscular dystrophy]] (MD). Stamulumab was formulated and tested by Wyeth in [[Collegeville, Pennsylvania]].<ref name="NCT00104078">{{Cite web|title=Study Evaluating MYO-029 in Adult Muscular Dystrophy 
| date = 24 June 2007
|url=https://clinicaltrials.gov/ct2/show/NCT00104078|access-date=2023-02-19|website=clinicaltrials.gov|language=en}}</ref> Myostatin is a [[protein]] that inhibits the growth of muscle tissue, stamulumab is a [[Recombinant DNA|recombinant]] human [[antibody]] designed to bind to and inhibit the activity of myostatin.<ref>{{Cite press release 
| archive-url= https://web.archive.org/web/20050315140242/https://www.medicalnewstoday.com/medicalnews.php?newsid=20441
| archive-date= 15 March 2005
|url=https://www.medicalnewstoday.com/medicalnews.php?newsid=20441
| url-status=unfit 
| title= Wyeth Initiates Clinical Trial with Investigational Muscular Dystrophy Therapy MYO-029
| date = 28 February 2005
|access-date=2023-02-19|website=www.medicalnewstoday.com|language=en}}</ref>

Stamulumab is a [[G1 phase|G1]] [[immunoglobulin]] antibody which binds to myostatin and prevents it from binding to its target site, thus inhibiting the growth-limiting action of myostatin on muscle tissue. Research completed in 2002 found that Stamulumab might one day prove to be an effective treatment for [[Duchenne muscular dystrophy]].<ref name="MDA 112702">{{Cite web
| archive-url= https://web.archive.org/web/20021222005143/http://www.mdausa.org/news/021127micedmd.html
| archive-date= 22 December 2002
| url-status=dead
| title=Blocking Myostatin Proves Beneficial in Mice with DMD
| date = 27 November 2002
|url=http://www.mdausa.org/news/021127micedmd.html|access-date=2023-02-19|website=MDA Research News}}</ref>

==Phase 1 and 2 trials==
Wyeth undertook a Phase 1 and 2 [[clinical trial]] in 2005 and 2006 of stamulumab. The multiple ascending dose trial (36 patients per [[cohort study|cohort]]) contained some measures of efficacy. The trial's participants included people afflicted with [[facioscapulohumeral muscular dystrophy]], [[Becker's muscular dystrophy]], and [[Limb-girdle muscular dystrophy]]. Through 2007 Wyeth had been analyzing the results but the hoped-for news and/or a publication in 2007 did not occur.<ref name="NCT00104078"/><ref name="being analyzed">[http://www.mda.org/research/061204myo_029_nov06.html Wyeth Analyzing MYO-029 Results] {{Webarchive|url=https://archive.today/20130415094420/http://www.mda.org/research/061204myo_029_nov06.html |date=2013-04-15 }}, [[Muscular Dystrophy Association]] announcement, December 4, 2006</ref><ref name="FSHWatch 2007">[http://www.fshsociety.org/fsh/FSHSociety_FSHWatchNewsletterSummer2007.pdf FSH Watch Newsletter] {{Webarchive|url=https://web.archive.org/web/20080309013417/http://www.fshsociety.org/fsh/FSHSociety_FSHWatchNewsletterSummer2007.pdf|date=2008-03-09}}, pg 11, [[FSH Society]], Summer 2007</ref> On January 24, 2008, Wyeth announced that the study had been accepted by a peer-reviewed journal and publication was expected "in the next few months".<ref name="Wiredsciencejan08">{{Cite magazine|last=Madrigal|first=Alexis
| date = 24 January 2008
|title=Pharma Company Responds to WiSci on Muscle-Building Drug|language=en-US|magazine=Wired|url=https://www.wired.com/2008/01/pharma-company/|access-date=2023-02-19|issn=1059-1028}}</ref> The publication appeared in ''[[Annals of Neurology]]'' in May 2008.<ref name="AnnNeurol2008">{{cite journal | vauthors = Wagner KR, Fleckenstein JL, Amato AA, Barohn RJ, Bushby K, Escolar DM, Flanigan KM, Pestronk A, Tawil R, Wolfe GI, Eagle M, Florence JM, King WM, Pandya S, Straub V, Juneau P, Meyers K, Csimma C, Araujo T, Allen R, Parsons SA, Wozney JM, Lavallie ER, Mendell JR | display-authors = 6 | title = A phase I/IItrial of MYO-029 in adult subjects with muscular dystrophy | journal = Annals of Neurology | volume = 63 | issue = 5 | pages = 561–71 | date = May 2008 | pmid = 18335515 | doi = 10.1002/ana.21338 | s2cid = 9934165 | doi-access = free }}</ref>

On 11 March 2008, it was announced that Wyeth would not develop the drug further for MD, but would continue to explore myostatin inhibition along with other strategies.<ref>{{Cite web|url=http://www.mda.org/research/080311md_myo-029.html
| date = 11 March 2008
|title=Wyeth Won't Develop MYO-029 for MD|access-date=2008-11-03|archive-date=2012-09-06|archive-url=https://archive.today/20120906121040/http://www.mda.org/research/080311md_myo-029.html|url-status=dead}}</ref>

==See also==
* [[ACVR2B]] represents an alternative approach to inhibiting myostatin. Not belonging to the antibody class of molecules, the ACVR2B protein drug is rather mimicking myostatin's endogenous binding partner, therefore competing for its binding affinity.<ref name="MDA 010606">{{Cite web
| archive-date= 11 January 2006
| archive-url=https://web.archive.org/web/20060111050055/http://www.mdausa.org/research/060106myostatin_blocker.html
|url=http://www.mdausa.org/research/060106myostatin_blocker.html
| url-status= dead 
|access-date=2023-02-19
| title=New Myostatin Blocker Makes Mouse Muscles 60 Percent Larger
|website=MDA Research News
| date= 6 January 2006}}</ref>

==References==
<references/>

{{Monoclonals for bone, musculoskeletal, circulatory, and neurologic systems}}
{{Muscular Dystrophy}}
{{TGFβ receptor superfamily modulators}}

[[Category:Drugs developed by Wyeth]]
[[Category:Abandoned drugs]]
[[Category:Monoclonal antibodies]]
[[Category:Myostatin inhibitors]]