View source for Small temporal RNA

'''Small temporal RNA''' (abbreviated '''stRNA''') regulates gene expression during [[nematode|roundworm]] development by preventing the [[messenger RNA|mRNA]]s they bind from being translated.<ref name="pmid11486075">{{cite journal | vauthors = Ambros V | title = Development. Dicing up RNAs | journal = Science | volume = 293 | issue = 5531 | pages = 811–3 | date = August 2001 | pmid = 11486075 | doi = 10.1126/science.1064400 | s2cid = 45706655 }}</ref> In contrast to [[siRNA]], stRNAs downregulate expression of target RNAs after translation initiation without affecting [[mRNA stability]].<ref>{{cite journal | vauthors = Grosshans H, Slack FJ | title = Micro-RNAs: small is plentiful | journal = The Journal of Cell Biology | volume = 156 | issue = 1 | pages = 17–21 | date = January 2002 | pmid = 11781331 | pmc = 2173595 | doi = 10.1083/jcb.200111033 }}</ref> Nowadays, stRNAs are better known as [[miRNA]]s.

stRNAs exert negative post-transcriptional regulation by binding to complementary sequences in the 3' untranslated regions of their target genes. stRNAs are transcribed as longer precursor RNAs that are processed by the RNase [[Dicer]]/DCR-1 and members of the [[RDE-1]]/[[AGO1]] [[family of proteins]], which are better known for their roles in [[RNA interference]] ([[RNAi]]). stRNAs may function to control temporal identity during development in ''[[Caenorhabditis elegans|C. elegans]]'' and other organisms.<ref>{{cite journal | vauthors = Banerjee D, Slack F | title = Control of developmental timing by small temporal RNAs: a paradigm for RNA-mediated regulation of gene expression | journal = BioEssays | volume = 24 | issue = 2 | pages = 119–29 | date = February 2002 | pmid = 11835276 | doi = 10.1002/bies.10046 | doi-access = free }}</ref>

== References ==
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{{natural antisense transcripts}}
{{Nucleic acids}}

[[Category:RNA]]
[[Category:RNA interference]]

{{molecular-biology-stub}}