View source for Second-generation antidepressant

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| Use = [[Mood disorder#Depressive disorders|Depressive disorders]]
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The '''second-generation antidepressants''' are a class of [[antidepressants]] characterized primarily by the era of their introduction, approximately coinciding with the 1970s and 1980s, rather than by their [[chemical structure]] or by their [[pharmacological effect]]. As a consequence, there is some controversy over which treatments actually belong in this class.

The term "third generation antidepressant" is sometimes used to refer to newer antidepressants,<ref name="pmid11735614">{{cite journal |vauthors=Olver JS, Burrows GD, Norman TR |title=Third-generation antidepressants: do they offer advantages over the SSRIs? |journal=CNS Drugs |volume=15 |issue=12 |pages=941–54 |year=2001 |pmid=11735614 |doi= 10.2165/00023210-200115120-00004|s2cid=39029287 }}</ref> from the 1990s and 2000s, often [[selective serotonin reuptake inhibitor]]s (SSRIs) such as; [[fluoxetine]] (Prozac), [[paroxetine]] (Paxil) and [[sertraline]] (Zoloft), as well as some non-SSRI antidepressants such as [[mirtazapine]], [[nefazodone]], [[venlafaxine]], [[duloxetine]] and [[reboxetine]]. However, this usage is not universal.

==Examples==
This list is not exhaustive, and different sources vary upon which items should be considered second-generation.
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* [[Amineptine]]
* [[Amoxapine]]
* [[Bupropion]]
* [[Iprindole]]
* [[Maprotiline]]
* [[Medifoxamine]]
* [[Mianserin]]
* [[Nomifensine]]
* [[Tianeptine]]
* [[Trazodone]]
* [[Venlafaxine]]
* [[Viloxazine]]
* [[Sertraline]]
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==See also==
{{Portal|Medicine}}
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* {{Annotated link |Atypical antidepressant}}
* {{Annotated link |Development and discovery of SSRI drugs}}
* {{Annotated link |Pharmacology of antidepressants}}
* {{Annotated link |Tricyclic antidepressant}}
* {{Annotated link |Tetracyclic antidepressant}}
* {{Annotated link |Serotonin–norepinephrine reuptake inhibitor}}
* {{Annotated link |Serotonin antagonist and reuptake inhibitor}}
* {{Annotated link |Noradrenergic and specific serotonergic antidepressant}}
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==References==
{{Reflist|2}}

==External links==
* {{MeshName|Second-Generation+Antidepressive+Agents}}
* [http://www.toxlab.co.uk/tca2nd.htm#Second%20Generation Diagrams at toxlab.co.uk]
* [http://jcp.sagepub.com/cgi/content/abstract/25/4/241 Overview at sagepub.com]
* [http://psyweb.com/Glossary/sga.jsp Overview at psyweb.com]
* [https://www.sciencedaily.com/releases/2005/09/050920081731.htm Overview at sciencedaily.com]
* [http://sabryabdelfattah.tripod.com/docs/ANTIDPRS.htm Overview at sabryabdelfattah.tripod.com]

{{Antidepressants}}

[[Category:Antidepressants]]


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