View source for SDHB

{{Short description|Protein-coding gene in the species Homo sapiens}}
{{for|the [[district health board]] in New Zealand|Southern District Health Board}}
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{{Infobox gene}}

'''Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial''' (SDHB) also known as '''iron-sulfur subunit of complex II''' (Ip) is a [[protein]] that in humans is encoded by the ''SDHB'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: succinate dehydrogenase complex | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6390 }}</ref><ref name="Kita_1990">{{cite journal | vauthors = Kita K, Oya H, Gennis RB, Ackrell BA, Kasahara M | title = Human complex II (succinate-ubiquinone oxidoreductase): cDNA cloning of iron sulfur (Ip) subunit of liver mitochondria | journal = Biochemical and Biophysical Research Communications | volume = 166 | issue = 1 | pages = 101–108 | date = January 1990 | pmid = 2302193 | doi = 10.1016/0006-291X(90)91916-G }}</ref><ref name="Au_1995">{{cite journal | vauthors = Au HC, Ream-Robinson D, Bellew LA, Broomfield PL, Saghbini M, Scheffler IE | title = Structural organization of the gene encoding the human iron-sulfur subunit of succinate dehydrogenase | journal = Gene | volume = 159 | issue = 2 | pages = 249–253 | date = July 1995 | pmid = 7622059 | doi = 10.1016/0378-1119(95)00162-Y | doi-access = free }}</ref>

The [[succinate dehydrogenase]] (also called SDH or Complex II) protein complex [[Catalysis|catalyzes]]  the oxidation of succinate (succinate + ubiquinone => fumarate + ubiquinol). SDHB is one of four protein subunits forming succinate dehydrogenase, the other three being [[SDHA]], [[succinate dehydrogenase complex subunit C|SDHC]] and [[SDHD]]. The SDHB subunit is connected to the [[SDHA]] subunit on the hydrophilic, catalytic end of the SDH complex. It is also connected to the [[succinate dehydrogenase complex subunit C|SDHC]]/[[SDHD]] subunits on the hydrophobic end of the complex anchored in the mitochondrial membrane. The subunit is an [[iron-sulfur protein]] with three iron-sulfur clusters. It weighs 30 [[Atomic mass unit|kDa]].

==Structure==
The gene that codes for the SDHB protein is [[Nuclear DNA|nuclear]], not [[mitochondrial DNA]]. However, the expressed protein is located in the inner membrane of the [[mitochondria]]. The location of the gene in humans is on the [[Chromosome 1 (human)|first chromosome]] at  [[Locus (genetics)|locus]] p36.1-p35. The [[gene]] is coded in 1,162 base pairs, partitioned in 8 [[exon]]s.<ref name="entrez" /> The expressed protein weighs 31.6 kDa and is composed of 280 amino acids.<ref name="Zong_2013">{{cite journal | vauthors = Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya I, Liem D, Meyer D, Odeberg J, Fang C, Lu HJ, Xu T, Weiss J, Duan H, Uhlen M, Yates JR, Apweiler R, Ge J, Hermjakob H, Ping P | title = Integration of cardiac proteome biology and medicine by a specialized knowledgebase | journal = Circulation Research | volume = 113 | issue = 9 | pages = 1043–1053 | date = Oct 2013 | pmid = 23965338 | pmc = 4076475 | doi = 10.1161/CIRCRESAHA.113.301151 }}</ref><ref name="url_COPaKB">{{cite web | title = SDHB - Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial | url = https://amino.heartproteome.org/web/protein/P21912 | work = Cardiac Organellar Protein Atlas Knowledgebase (COPaKB) | access-date = 2018-07-18 | archive-date = 2018-07-19 | archive-url = https://web.archive.org/web/20180719024425/https://amino.heartproteome.org/web/protein/P21912 | url-status = dead }}</ref> SDHB contains the [[iron-sulphur cluster]]s necessary for tunneling electrons through the complex. It is located between [[SDHA]] and the two [[transmembrane]] subunits [[SDHC (gene)|SDHC]] and [[SDHD]].<ref>{{cite journal | vauthors = Sun F, Huo X, Zhai Y, Wang A, Xu J, Su D, Bartlam M, Rao Z | title = Crystal structure of mitochondrial respiratory membrane protein complex II. | journal = Cell | volume = 121 | issue = 7 | pages = 1043–1057 | date = 1 July 2005 | pmid = 15989954 | doi = 10.1016/j.cell.2005.05.025 | s2cid = 16697879 | doi-access = free }}</ref>

==Function==
[[Image:SDHBfunction.svg|thumb|right|300px|'''Figure 1''': Function of the SDHB protein. Electrons are transferred from the Citric Acid Cycle to the Respiratory Chain. Electron path is shown by red arrows.]]

The SDH complex is located on the inner membrane of the [[mitochondria]] and participates in both the [[Citric Acid Cycle]] and [[Respiratory chain]]. SDHB acts as an intermediate in the basic SDH enzyme action shown in Figure 1:
# [[SDHA]] converts [[succinate]] to [[fumarate]] as part of the [[Citric Acid Cycle]]. This reaction also converts [[flavin adenine dinucleotide|FAD]] to [[FADH2|FADH<sub>2</sub>]].
# Electrons from the FADH<sub>2</sub> are transferred to the SDHB subunit [[Iron-sulfur protein|iron clusters]] [2Fe-2S],[4Fe-4S],[3Fe-4S]. 
# Finally the electrons are transferred to the [[Ubiquinone]] (Q) pool via the [[succinate dehydrogenase complex subunit C|SDHC]]/[[SDHD]] subunits. This function is part of the [[Respiratory chain]].

Initially, [[SDHA]] oxidizes [[succinate]] via [[deprotonation]] at the FAD binding site, forming FADH<sub>2</sub> and leaving [[fumarate]], loosely bound to the active site, free to exit the protein. Electrons from FADH<sub>2</sub> are transferred to the SDHB subunit [[Iron-sulfur protein|iron clusters]] [2Fe-2S],[4Fe-4S],[3Fe-4S] and tunnel along the [Fe-S] relay until they reach the [3Fe-4S] [[iron sulfur cluster]]. The electrons are then transferred to an awaiting [[ubiquinone]] molecule at the Q pool active site in the [[SDHC (gene)|SDHC]]/[[SDHD]] dimer. The O1 [[carbonyl]] oxygen of ubiquinone is oriented at the active site (image 4) by [[hydrogen bond]] interactions with Tyr83 of [[SDHD]]. The presence of electrons in the [3Fe-4S] iron sulphur cluster induces the movement of ubiquinone into a second orientation. This facilitates a second hydrogen bond interaction between the O4 carbonyl group of ubiquinone and Ser27 of [[SDHC (gene)|SDHC]]. Following the first single electron reduction step, a [[semiquinone]] radical species is formed. The second electron arrives from the [3Fe-4S] cluster to provide full reduction of the ubiquinone to [[ubiquinol]].<ref>{{cite journal | vauthors = Horsefield R, Yankovskaya V, Sexton G, Whittingham W, Shiomi K, Omura S, Byrne B, Cecchini G, Iwata S | title = Structural and computational analysis of the quinone-binding site of complex II (succinate-ubiquinone oxidoreductase): a mechanism of electron transfer and proton conduction during ubiquinone reduction. | journal = The Journal of Biological Chemistry | volume = 281 | issue = 11 | pages = 7309–7316 | date = 17 March 2006 | pmid = 16407191 | doi = 10.1074/jbc.m508173200 | doi-access = free }}</ref>

== Clinical significance ==

[[Germline]] mutations in the gene can cause familial [[paraganglioma]] (in old nomenclature, Paraganglioma Type PGL4). The same condition is often called familial [[pheochromocytoma]]. Less frequently, [[renal cell carcinoma]] can be caused by  this mutation.

Paragangliomas  related to SDHB mutations have a high rate of malignancy. When malignant, treatment is currently the same as for any malignant paraganglioma/pheochromocytoma.

=== Cancer ===

Paragangliomas caused by SDHB mutations have several distinguishing characteristics:

# Malignancy is common, ranging from 38%-83%<ref name="Neumann_2004">{{cite journal | vauthors = Neumann HP, Pawlu C, Peczkowska M, Bausch B, McWhinney SR, Muresan M, Buchta M, Franke G, Klisch J, Bley TA, Hoegerle S, Boedeker CC, Opocher G, Schipper J, Januszewicz A, Eng C | title = Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations | journal = JAMA | volume = 292 | issue = 8 | pages = 943–951 | date = August 2004 | pmid = 15328326 | doi = 10.1001/jama.292.8.943 | s2cid = 21673619 }}</ref><ref name="Brouwers_2006">{{cite journal | vauthors = Brouwers FM, Eisenhofer G, Tao JJ, Kant JA, Adams KT, Linehan WM, Pacak K | title = High frequency of SDHB germline mutations in patients with malignant catecholamine-producing paragangliomas: implications for genetic testing | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 91 | issue = 11 | pages = 4505–4509 | date = November 2006 | pmid = 16912137 | doi = 10.1210/jc.2006-0423 | doi-access = free }}</ref> in carriers with disease. In contrast,  tumors caused by [[SDHD]] mutations are almost always benign. Sporadic paragangliomas are malignant in less than 10% of cases.  
# Malignant paragangliomas caused by SDHB are usually (perhaps 92%<ref name="Brouwers_2006" />) extra-adrenal. Sporadic pheochromocytomas/paragangliomas are extra-adrenal in less than 10% of cases.  
# The [[penetrance]] of the gene is often reported as 77% by age 50<ref name="Neumann_2004" /> (i.e. 77% of carriers will have at least one tumour by the age of 50). This is likely an overestimate. Currently (2011), families with silent SDHB mutations are being screened<ref name="NIH">Conference: National Institute of Health (U.S.A.), "SDHB-related Pheochromocytoma: Recent Discoveries & Current Diagnostic and Therapeutic Approaches", September 29, 2006</ref> to determine the frequency of silent carriers. 
# The average age of onset is approximately the same for SDHB vs non-SDHB related disease (approximately 36 years).

Mutations causing disease have been seen in [[exon]]s 1 through 7, but not 8. As with  the SDHC and [[SDHD]] genes, SDHB is a [[tumor suppressor gene]].

Tumor formation generally follows the Knudson [[Knudson hypothesis|"two hit"]] hypothesis. The first copy of the gene is mutated in all cells, however the second copy functions normally. When the second copy mutates in a certain cell due to a random event, [[Loss of heterozygosity|Loss of Heterozygosity (LOH)]] occurs and the SDHB protein is no longer produced. Tumor formation then becomes possible.

Given the fundamental nature of the SDH protein in all cellular function, it is not currently understood why only paraganglionic cells are affected. However, the sensitivity of these cells to oxygen levels may play a role.

=== Disease pathways ===

The precise pathway leading from SDHB mutation to tumorigenesis is not determined; there are several proposed mechanisms.<ref name="Gottlieb_2005">{{cite journal | vauthors = Gottlieb E, Tomlinson IP | title = Mitochondrial tumour suppressors: a genetic and biochemical update | journal = Nature Reviews. Cancer | volume = 5 | issue = 11 | pages = 857–866 | date = November 2005 | pmid = 16327764 | doi = 10.1038/nrc1737 | s2cid = 20851047 }}</ref>
  
==== Generation of reactive oxygen species====

[[Image:SDHBpathways.svg|thumb|right|300px|'''Figure 2''': Disease Pathways for SDHB mutations. Electron path during normal function is  shown by solid red arrows. Red dashed arrow shows superoxide generation (Pathway 1). Purple dashed arrow shows diffusion of succinate to block PHD (Pathway 2). Black crosses indicate the non-mutated process is blocked.]]

When succinate-ubiquinone activity is inhibited, electrons that would normally transfer through the SDHB subunit to the Ubiquinone pool are instead transferred to O<sub>2</sub> to create Reactive Oxygen Species (ROS) such as [[superoxide]]. The dashed red arrow in Figure 2 shows this. ROS accumulate and stabilize the production of [[Hypoxia inducible factor|HIF1-α]]. HIF1-α combines with HIF1-β to form the stable HIF heterodimeric complex, in turn leading to the induction  of [[apoptosis|antiapoptotic]] genes in the cell nucleus.

==== Succinate accumulation in the cytosol ====

SDH inactivation can block the oxidation of [[succinate]], starting a cascade of reactions:
# The succinate accumulated in the mitochondrial matrix  diffuses through the inner and outer mitochondrial membranes to the [[cytosol]] (purple dashed arrows in  Figure 2).
# Under normal cellular function, [[Hypoxia inducible factor|HIF1-α]] in the cytosol is quickly [[hydroxylation|hydroxylated]] by [[prolyl hydroxylase]] (PHD), shown with the light blue arrow. This process is blocked by the accumulated succinate. 
# HIF1-α stabilizes and passes to the cell nucleus (orange arrow) where it combines with HIF1-β to form an active HIF complex that induces the expression of tumor causing genes.<ref name="Selak_2005">{{cite journal | vauthors = Selak MA, Armour SM, MacKenzie ED, Boulahbel H, Watson DG, Mansfield KD, Pan Y, Simon MC, Thompson CB, Gottlieb E | title = Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase | journal = Cancer Cell | volume = 7 | issue = 1 | pages = 77–85 | date = January 2005 | pmid = 15652751 | doi = 10.1016/j.ccr.2004.11.022 | doi-access = free }}</ref>

This pathway raises the possibility of a therapeutic treatment. The build-up of succinate inhibits PHD activity. PHD action normally requires oxygen and [[α-ketoglutarate|alpha-ketoglutarate]] as [[cosubstrate]]s and ferrous iron and [[Vitamin C|ascorbate]] as [[cofactor (biochemistry)|cofactors]]. Succinate competes with α-ketoglutarate in binding to the PHD enzyme. Therefore, increasing α-ketoglutarate levels can offset the effect of succinate accumulation.

Normal α-ketoglutarate does not permeate cell walls efficiently, and it is necessary to create a cell permeating derivative (e.g. α-ketoglutarate esters). In-vitro trials show this supplementation approach can reduce HIF1-α levels, and may result in a therapeutic approach to tumours resulting from SDH deficiency.<ref name="MacKenzie_2007">{{cite journal | vauthors = MacKenzie ED, Selak MA, Tennant DA, Payne LJ, Crosby S, Frederiksen CM, Watson DG, Gottlieb E | title = Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells | journal = Molecular and Cellular Biology | volume = 27 | issue = 9 | pages = 3282–3289 | date = May 2007 | pmid = 17325041 | pmc = 1899954 | doi = 10.1128/MCB.01927-06 }}</ref>

====  Impaired developmental apoptosis ====

Paraganglionic tissue is derived from the [[neural crest]] cells present in an [[embryo]]. Abdominal extra-adrenal paraganglionic cells secrete catecholamines that play an important role in fetal development. After birth these cells usually die, a process that is triggered by a decline in [[nerve growth factor]] (NGF)which initiates [[apoptosis]] (cell death).

This cell death process is mediated by an enzyme called prolyl hydroxylase EglN3. Succinate accumulation caused by SDH inactivation inhibits the prolyl hydroxylase EglN3.<ref name="Lee_2005">{{cite journal | vauthors = Lee S, Nakamura E, Yang H, Wei W, Linggi MS, Sajan MP, Farese RV, Freeman RS, Carter BD, Kaelin WG, Schlisio S | title = Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer | journal = Cancer Cell | volume = 8 | issue = 2 | pages = 155–167 | date = August 2005 | pmid = 16098468 | doi = 10.1016/j.ccr.2005.06.015 | doi-access = free }}</ref> The net result is that paranglionic tissue that would normally die after birth remains, and this tissue may be able to trigger paraganglioma/pheochromocytoma later.

==== Glycolysis upregulation ====
Inhibition of the Citric Acid Cycle forces the cell to create [[adenosine triphosphate|ATP]] glycolytically in order to generate its required energy. The induced glycolytic enzymes could potentially block cell apoptosis.

===RNA editing===
The mRNA transcripts of the SDHB gene in human are edited through an unknown mechanism at ORF nucleotide position 136 causing the conversion of C to U and thus generating a stop codon resulting in the translation of the edited transcripts to a truncated SDHB protein with an R46X amino acid change. This editing has been shown in [[monocytes]] and some human lymphoid cell-lines,<ref name="Baysal_2007">{{cite journal | vauthors = Baysal BE | title = A recurrent stop-codon mutation in succinate dehydrogenase subunit B gene in normal peripheral blood and childhood T-cell acute leukemia | journal = PLOS ONE | volume = 2 | issue = 5 | pages = e436 | date = May 2007 | pmid = 17487275 | pmc = 1855983 | doi = 10.1371/journal.pone.0000436 | bibcode = 2007PLoSO...2..436B | doi-access = free }} {{open access}}</ref> and is enhanced by [[Hypoxia (medical)|hypoxia]].<ref name="Baysal_2013">{{cite journal | vauthors = Baysal BE, De Jong K, Liu B, Wang J, Patnaik SK, Wallace PK, Taggart RT | title = Hypoxia-inducible C-to-U coding RNA editing downregulates SDHB in monocytes | journal = PeerJ | volume = 1 | pages = e152 | year = 2013 | pmid = 24058882 | pmc = 3775634 | doi = 10.7717/peerj.152 | doi-access = free }}</ref>

== Interactive pathway map ==
{{TCACycle_WP78|highlight=SDHB}}

== References ==
{{reflist|2}}

== Further reading ==
{{refbegin | 2}}
*{{cite journal | vauthors = Milosevic D, Lundquist P, Cradic K, Vidal-Folch N, Huynh T, Pacak K, Grebe SK | title = Development and validation of a comprehensive mutation and deletion detection assay for SDHB, SDHC, and SDHD | journal = Clinical Biochemistry | volume = 43 | issue = 7–8 | pages = 700–704 | date = May 2010 | pmid = 20153743 | pmc = 3419008 | doi = 10.1016/j.clinbiochem.2010.01.016 }}
*{{cite journal | vauthors = Alrashdi I, Bano G, Maher ER, Hodgson SV | title = Carney triad versus Carney Stratakis syndrome: two cases which illustrate the difficulty in distinguishing between these conditions in individual patients | journal = Familial Cancer | volume = 9 | issue = 3 | pages = 443–447 | date = Sep 2010 | pmid = 20119652 | doi = 10.1007/s10689-010-9323-z | s2cid = 21792188 }}
*{{cite journal | vauthors = Okada Y, Kamatani Y, Takahashi A, Matsuda K, Hosono N, Ohmiya H, Daigo Y, Yamamoto K, Kubo M, Nakamura Y, Kamatani N | title = A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci | journal = Human Molecular Genetics | volume = 19 | issue = 11 | pages = 2303–2312 | date = Jun 2010 | pmid = 20189936 | doi = 10.1093/hmg/ddq091 | doi-access = free }}
*{{cite journal | vauthors = Bayley JP | title = Are these compound heterozygous mutations of SDHB really mutations? | journal = Pediatric Blood & Cancer | volume = 55 | issue = 1 | pages = 211; author reply 212 | date = Jul 2010 | pmid = 20213850 | doi = 10.1002/pbc.22455 | s2cid = 31378042 }}
*{{cite journal | vauthors = Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR | title = Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score | journal = Molecular Medicine | location = Cambridge, Mass. | volume = 16 | issue = 7–8 | pages = 247–253 | year = 2010 | pmid = 20379614 | pmc = 2896464 | doi = 10.2119/molmed.2009.00159 }}
*{{cite journal | vauthors = Gill AJ, Benn DE, Chou A, Clarkson A, Muljono A, Meyer-Rochow GY, Richardson AL, Sidhu SB, Robinson BG, Clifton-Bligh RJ | title = Immunohistochemistry for SDHB triages genetic testing of SDHB, SDHC, and SDHD in paraganglioma-pheochromocytoma syndromes | journal = Human Pathology | volume = 41 | issue = 6 | pages = 805–814 | date = Jun 2010 | pmid = 20236688 | doi = 10.1016/j.humpath.2009.12.005 }}
*{{cite journal | vauthors = Martin TP, Irving RM, Maher ER | title = The genetics of paragangliomas: a review | journal = Clinical Otolaryngology | volume = 32 | issue = 1 | pages = 7–11 | date = Feb 2007 | pmid = 17298303 | doi = 10.1111/j.1365-2273.2007.01378.x | doi-access = free }}
*{{cite journal | vauthors = Eng C, Kiuru M, Fernandez MJ, Aaltonen LA | title = A role for mitochondrial enzymes in inherited neoplasia and beyond | journal = Nature Reviews. Cancer | volume = 3 | issue = 3 | pages = 193–202 | date = Mar 2003 | pmid = 12612654 | doi = 10.1038/nrc1013 | s2cid = 20549458 }}
*{{cite journal | vauthors = Lee J, Wang J, Torbenson M, Lu Y, Liu QZ, Li S | title = Loss of SDHB and NF1 genes in a malignant phyllodes tumor of the breast as detected by oligo-array comparative genomic hybridization | journal = Cancer Genetics and Cytogenetics | volume = 196 | issue = 2 | pages = 179–183 | date = Jan 2010 | pmid = 20082856 | doi = 10.1016/j.cancergencyto.2009.09.005 }}
*{{cite journal | vauthors = Hermsen MA, Sevilla MA, Llorente JL, Weiss MM, Grimbergen A, Allonca E, Garcia-Inclan C, Balbin M, Suarez C | title = Relevance of germline mutation screening in both familial and sporadic head and neck paraganglioma for early diagnosis and clinical management | journal = Cellular Oncology | volume = 32 | issue = 4 | pages = 275–283 | date = Jan 2010 | pmid = 20208144 | pmc = 4619289 | doi = 10.3233/CLO-2009-0498 }}
*{{cite journal | vauthors = Musil Z, Puchmajerova A, Krepelova A, Vicha A, Panczak A, Vesela J, Widimsky J, Turkova H, Lisy J, Kohoutova M | title = Paraganglioma in a 13-year-old girl: a novel SDHB gene mutation in the family? | journal = Cancer Genetics and Cytogenetics | volume = 197 | issue = 2 | pages = 189–192 | date = Mar 2010 | pmid = 20193854 | doi = 10.1016/j.cancergencyto.2009.11.010 }}
*{{cite journal | vauthors = Shimada M, Miyagawa T, Kawashima M, Tanaka S, Honda Y, Honda M, Tokunaga K | title = An approach based on a genome-wide association study reveals candidate loci for narcolepsy | journal = Human Genetics | volume = 128 | issue = 4 | pages = 433–441 | date = Oct 2010 | pmid = 20677014 | doi = 10.1007/s00439-010-0862-z | s2cid = 24207887 }}
*{{cite journal | vauthors = Briere JJ, Favier J, Ghouzzi V, Djouadi F, Benit P, Gimenez AP, Rustin P | title = Succinate dehydrogenase deficiency in human | journal = Cellular and Molecular Life Sciences  | volume = 62 | issue = 19–20 | pages = 2317–2324 | date = Oct 2005 | pmid = 16143825 | pmc = 11139140 | doi = 10.1007/s00018-005-5237-6 | s2cid = 23793565 }}
*{{cite journal | vauthors = Schimke RN, Collins DL, Stolle CA | title = Paraganglioma, neuroblastoma, and a SDHB mutation: Resolution of a 30-year-old mystery | journal = American Journal of Medical Genetics. Part A | volume = 152A | issue = 6 | pages = 1531–1535 | date = Jun 2010 | pmid = 20503330 | doi = 10.1002/ajmg.a.33384 | s2cid = 22768946 }}
*{{cite journal | vauthors = Gill AJ, Chou A, Vilain R, Clarkson A, Lui M, Jin R, Tobias V, Samra J, Goldstein D, Smith C, Sioson L, Parker N, Smith RC, Sywak M, Sidhu SB, Wyatt JM, Robinson BG, Eckstein RP, Benn DE, Clifton-Bligh RJ | title = Immunohistochemistry for SDHB divides gastrointestinal stromal tumors (GISTs) into 2 distinct types | journal = The American Journal of Surgical Pathology | volume = 34 | issue = 5 | pages = 636–644 | date = May 2010 | pmid = 20305538 | doi = 10.1097/PAS.0b013e3181d6150d | s2cid = 2314622 }}
*{{cite journal | vauthors = Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ | title = Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression | journal = PLOS ONE | volume = 5 | issue = 9 | pages = e12862 | date = Sep 2010 | pmid = 20877624 | pmc = 2943476 | doi = 10.1371/journal.pone.0012862 | bibcode = 2010PLoSO...512862H | doi-access = free }} {{open access}}
*{{cite journal | vauthors = Cerecer-Gil NY, Figuera LE, Llamas FJ, Lara M, Escamilla JG, Ramos R, Estrada G, Hussain AK, Gaal J, Korpershoek E, Krijger RR, Dinjens WN, Devilee P, Bayley JP | title = Mutation of SDHB is a cause of hypoxia-related high-altitude paraganglioma | journal = Clinical Cancer Research | volume = 16 | issue = 16 | pages = 4148–4154 | date = Aug 2010 | pmid = 20592014 | doi = 10.1158/1078-0432.CCR-10-0637 | s2cid = 12502978 }}
*{{cite journal | vauthors = Krawczyk A, Hasse-Lazar K, Pawlaczek A, Szpak-Ulczok S, Krajewska J, Paliczka-Cieslak E, Jurecka-Lubieniecka B, Roskosz J, Chmielik E, Ziaja J, Cierpka L, Peczkowska M, Preibisz A, Januszewicz A, Otto M, Jarzab B | title = Germinal mutations of RET, SDHB, SDHD, and VHL genes in patients with apparently sporadic pheochromocytomas and paragangliomas | journal = Endokrynologia Polska | volume = 61 | issue = 1 | pages = 43–48 | year = 2010 | pmid = 20205103 }}
*{{cite journal | vauthors = Hes FJ, Weiss MM, Woortman SA, Miranda NF, Bunderen PA, Bonsing BA, Stokkel MP, Morreau H, Romijn JA, Jansen JC, Vriends AH, Bayley JP, Corssmit EP | title = Low penetrance of a SDHB mutation in a large Dutch paraganglioma family | journal = BMC Medical Genetics | volume = 11 | pages = 92 | date = Jun 2010 | pmid = 20540712 | pmc = 2891715 | doi = 10.1186/1471-2350-11-92 | doi-access = free }} {{open access}}
*{{cite journal | vauthors = Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S | title = Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study | journal = Diabetes Care | volume = 33 | issue = 10 | pages = 2250–2253 | date = Oct 2010 | pmid = 20628086 | pmc = 2945168 | doi = 10.2337/dc10-0452 }}
*{{cite journal | vauthors = Baysal BE | title = A Recurrent Stop-Codon Mutation in Succinate Dehydrogenase Subunit B Gene in Normal Peripheral Blood and Childhood T-Cell Acute Leukemia | journal = PLOS ONE | volume = 2 | issue = 5 | pages = e436 | date = May 2007 | pmid = 17487275 | pmc = 1855983 | doi = 10.1371/journal.pone.0000436 | bibcode = 2007PLoSO...2..436B | doi-access = free }} {{open access}}
*{{cite journal | vauthors = Baysal BE, Jong K, Liu B, Wang J, Patnaik SK, Wallace PK, Taggart RT | title = Hypoxia-inducible C-to-U coding RNA editing downregulates SDHB in monocytes | journal = PeerJ | volume = 1 | pages = e152 | year = 2013 | pmid = 24058882 | pmc = 3775634 | doi = 10.7717/peerj.152 | doi-access = free }}
{{refend}}

== External links ==
* [http://chromium.liacs.nl/lovd_sdh/index.php?select_db=SDHB Database of identified SDHB mutations.] {{Webarchive|url=https://web.archive.org/web/20060421214649/http://chromium.liacs.nl/lovd_sdh/index.php?select_db=SDHB |date=2006-04-21 }}

{{PDB Gallery|geneid=6390}}
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[[Category:EC 1.3.5]]
[[Category:Tumor suppressor genes]]